FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968544058> ?p ?o ?g. }

• W1968544058 endingPage "30" @default.
• W1968544058 startingPage "25" @default.
• W1968544058 abstract "A total of 103 isolates of Pseudomonas aeruginosa were studied to compare the in vitro effectiveness of three beta-lactam antibiotics (piperacillin, ticarcillin, and mezlocillin) when used alone and in combination with four aminoglycosides (tobramycin, gentamicin, amikacin, and netilmicin). All drugs were tested as single agents against a standard inoculum (5 X 10(5) CFU/ml). The three antipseudomonal penicillins were also tested against the isolates at a higher inoculum concentration (10(7) CFU/ml). Synergy testing was performed by the two-dimensional checkerboard method and was defined by a fractional bactericidal index of less than or equal to 0.5 and bacterial killing accomplished at antibiotic concentrations no greater than those achievable in serum. All combinations were assessed for synergy. The degree of synergy was further analyzed by dividing the isolates into groups based on their susceptibility and resistance to the individual agents in the combination. The overall effectiveness of the various aminoglycoside-antipseudomonal penicillin combinations was assessed regarding their ability to kill the isolates either as single agents or through synergy. Piperacillin was the most active antipseudomonal penicillin, and tobramycin and amikacin were the most active aminoglycosides when used as single agents. When tested against isolates at a higher inoculum concentration, ticarcillin was significantly more active than the other beta-lactams. The highest degree of overall synergy was noted with gentamicin-ticarcillin (78.2% of strains) and amikacin-piperacillin (77% of strains). When assessed for overall effectiveness, all combinations containing amikacin were the most active. The combination of amikacin-piperacillin was the most effective, with activity against 96% of all isolates." @default.
• W1968544058 created "2016-06-24" @default.
• W1968544058 creator A5002330647 @default.
• W1968544058 creator A5052473309 @default.
• W1968544058 creator A5052861766 @default.
• W1968544058 creator A5066136225 @default.
• W1968544058 creator A5076055627 @default.
• W1968544058 date "1986-07-01" @default.
• W1968544058 modified "2023-10-04" @default.
• W1968544058 title "In vitro activity of piperacillin, ticarcillin, and mezlocillin alone and in combination with aminoglycosides against Pseudomonas aeruginosa" @default.
• W1968544058 cites W1964308581 @default.
• W1968544058 cites W1965204604 @default.
• W1968544058 cites W1972586558 @default.
• W1968544058 cites W1972985689 @default.
• W1968544058 cites W1975948989 @default.
• W1968544058 cites W1979120751 @default.
• W1968544058 cites W1981123754 @default.
• W1968544058 cites W1986334023 @default.
• W1968544058 cites W2000402391 @default.
• W1968544058 cites W2008330785 @default.
• W1968544058 cites W2015286479 @default.
• W1968544058 cites W2030371182 @default.
• W1968544058 cites W2060724686 @default.
• W1968544058 cites W2086618328 @default.
• W1968544058 cites W2091970445 @default.
• W1968544058 cites W2095816775 @default.
• W1968544058 cites W2106319698 @default.
• W1968544058 cites W2112191861 @default.
• W1968544058 cites W2120452533 @default.
• W1968544058 cites W2134478832 @default.
• W1968544058 cites W2135777239 @default.
• W1968544058 cites W2147132959 @default.
• W1968544058 cites W2147634162 @default.
• W1968544058 cites W2154886762 @default.
• W1968544058 cites W2315875487 @default.
• W1968544058 cites W287538028 @default.
• W1968544058 doi "https://doi.org/10.1128/aac.30.1.25" @default.
• W1968544058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/176428" @default.
• W1968544058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3092731" @default.
• W1968544058 hasPublicationYear "1986" @default.
• W1968544058 type Work @default.
• W1968544058 sameAs 1968544058 @default.
• W1968544058 citedByCount "21" @default.
• W1968544058 countsByYear W19685440582015 @default.
• W1968544058 countsByYear W19685440582017 @default.
• W1968544058 countsByYear W19685440582018 @default.
• W1968544058 crossrefType "journal-article" @default.
• W1968544058 hasAuthorship W1968544058A5002330647 @default.
• W1968544058 hasAuthorship W1968544058A5052473309 @default.
• W1968544058 hasAuthorship W1968544058A5052861766 @default.
• W1968544058 hasAuthorship W1968544058A5066136225 @default.
• W1968544058 hasAuthorship W1968544058A5076055627 @default.
• W1968544058 hasBestOaLocation W19685440581 @default.
• W1968544058 hasConcept C174802600 @default.
• W1968544058 hasConcept C2775832221 @default.
• W1968544058 hasConcept C2776083883 @default.
• W1968544058 hasConcept C2776536040 @default.
• W1968544058 hasConcept C2777427914 @default.
• W1968544058 hasConcept C2777637488 @default.
• W1968544058 hasConcept C2777787772 @default.
• W1968544058 hasConcept C2778193466 @default.
• W1968544058 hasConcept C2778974779 @default.
• W1968544058 hasConcept C2778977604 @default.
• W1968544058 hasConcept C2779454058 @default.
• W1968544058 hasConcept C2779708577 @default.
• W1968544058 hasConcept C501593827 @default.
• W1968544058 hasConcept C523546767 @default.
• W1968544058 hasConcept C54355233 @default.
• W1968544058 hasConcept C71924100 @default.
• W1968544058 hasConcept C86803240 @default.
• W1968544058 hasConcept C89423630 @default.
• W1968544058 hasConceptScore W1968544058C174802600 @default.
• W1968544058 hasConceptScore W1968544058C2775832221 @default.
• W1968544058 hasConceptScore W1968544058C2776083883 @default.
• W1968544058 hasConceptScore W1968544058C2776536040 @default.
• W1968544058 hasConceptScore W1968544058C2777427914 @default.
• W1968544058 hasConceptScore W1968544058C2777637488 @default.
• W1968544058 hasConceptScore W1968544058C2777787772 @default.
• W1968544058 hasConceptScore W1968544058C2778193466 @default.
• W1968544058 hasConceptScore W1968544058C2778974779 @default.
• W1968544058 hasConceptScore W1968544058C2778977604 @default.
• W1968544058 hasConceptScore W1968544058C2779454058 @default.
• W1968544058 hasConceptScore W1968544058C2779708577 @default.
• W1968544058 hasConceptScore W1968544058C501593827 @default.
• W1968544058 hasConceptScore W1968544058C523546767 @default.
• W1968544058 hasConceptScore W1968544058C54355233 @default.
• W1968544058 hasConceptScore W1968544058C71924100 @default.
• W1968544058 hasConceptScore W1968544058C86803240 @default.
• W1968544058 hasConceptScore W1968544058C89423630 @default.
• W1968544058 hasIssue "1" @default.
• W1968544058 hasLocation W19685440581 @default.
• W1968544058 hasLocation W19685440582 @default.
• W1968544058 hasLocation W19685440583 @default.
• W1968544058 hasOpenAccess W1968544058 @default.
• W1968544058 hasPrimaryLocation W19685440581 @default.
• W1968544058 hasRelatedWork W1893091422 @default.
• W1968544058 hasRelatedWork W1968544058 @default.
• W1968544058 hasRelatedWork W1998600798 @default.

• next