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- W1968560756 abstract "In rats made cataleptic with haloperidol (5.32 μmol/kg), the bar test was used to assess the possible synergism between the muscarinic antagonist trihexyphenidyl (THP) and selective adenosine A1 and A2A receptor antagonists. Neither catalepsy intensity nor latency were affected by a subthreshold dose of THP (0.33 μmol/kg). The selective adenosine A1 antagonist 8-cyclopentyl-1,3-dipropyl-xanthine (DPCPX) (5.15 μmol/kg) caused a small, but significant reduction of catalepsy intensity that remained unchanged when combined with THP. DPCPX had no effect on catalepsy latency, either alone or combined with THP. In contrast, an equimolar dose of the selective adenosine A2A antagonist 4-(2-[7-amino-2-(2-furyl)1,2,4-triazolo[2,3-a]-[1,3,5]triazin-5-ylamino]ethyl)phenol (ZM 241385) (5.15 μmol/kg) produced a significant reduction of catalepsy intensity and increased catalepsy latency. Both effects were potentiated when ZM 241385 was combined with THP. The synergism was more evident when rats were pretreated with a subthreshold dose of ZM 241385 (1.55 μmol/kg) that was unable to modify catalepsy parameters when applied alone, but produced a significant reduction in catalepsy intensity and an increase in catalepsy latency when administered with THP. Catalepsy was unaffected by a combination of equimolar, subthreshold doses of DPCPX (1.55 μmol/kg) and ZM 241385 (1.55 μmol/kg). These findings indicate that the anticataleptic effect of anticholinergics is enhanced only by the selective blockade of adenosine A2A receptors." @default.
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- W1968560756 date "2003-07-01" @default.
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- W1968560756 title "Selective A2A, but not A1 adenosine antagonists enhance the anticataleptic action of trihexyphenidyl in rats" @default.
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- W1968560756 doi "https://doi.org/10.1016/s0304-3940(03)00337-9" @default.
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