FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968562444> ?p ?o ?g. }

• W1968562444 endingPage "8641" @default.
• W1968562444 startingPage "8633" @default.
• W1968562444 abstract "A novel microfluidic device that can selectively and specifically isolate exceedingly small numbers of circulating tumor cells (CTCs) through a monoclonal antibody (mAB) mediated process by sampling large input volumes (>/=1 mL) of whole blood directly in short time periods (<37 min) was demonstrated. The CTCs were concentrated into small volumes (190 nL), and the number of cells captured was read without labeling using an integrated conductivity sensor following release from the capture surface. The microfluidic device contained a series (51) of high-aspect ratio microchannels (35 mum width x 150 mum depth) that were replicated in poly(methyl methacrylate), PMMA, from a metal mold master. The microchannel walls were covalently decorated with mABs directed against breast cancer cells overexpressing the epithelial cell adhesion molecule (EpCAM). This microfluidic device could accept inputs of whole blood, and its CTC capture efficiency was made highly quantitative (>97%) by designing capture channels with the appropriate widths and heights. The isolated CTCs were readily released from the mAB capturing surface using trypsin. The released CTCs were then enumerated on-device using a novel, label-free solution conductivity route capable of detecting single tumor cells traveling through the detection electrodes. The conductivity readout provided near 100% detection efficiency and exquisite specificity for CTCs due to scaling factors and the nonoptimal electrical properties of potential interferences (erythrocytes or leukocytes). The simplicity in manufacturing the device and its ease of operation make it attractive for clinical applications requiring one-time use operation." @default.
• W1968562444 created "2016-06-24" @default.
• W1968562444 creator A5004453425 @default.
• W1968562444 creator A5004898072 @default.
• W1968562444 creator A5025642382 @default.
• W1968562444 creator A5029736335 @default.
• W1968562444 creator A5037587624 @default.
• W1968562444 creator A5038208939 @default.
• W1968562444 creator A5072235685 @default.
• W1968562444 creator A5072515852 @default.
• W1968562444 creator A5080438741 @default.
• W1968562444 creator A5087283200 @default.
• W1968562444 date "2008-06-17" @default.
• W1968562444 modified "2023-10-18" @default.
• W1968562444 title "Highly Efficient Circulating Tumor Cell Isolation from Whole Blood and Label-Free Enumeration Using Polymer-Based Microfluidics with an Integrated Conductivity Sensor" @default.
• W1968562444 cites W1558034062 @default.
• W1968562444 cites W1717462707 @default.
• W1968562444 cites W1848585043 @default.
• W1968562444 cites W1968475325 @default.
• W1968562444 cites W1969895447 @default.
• W1968562444 cites W1979160606 @default.
• W1968562444 cites W1985727076 @default.
• W1968562444 cites W1991702183 @default.
• W1968562444 cites W2010000042 @default.
• W1968562444 cites W2013403722 @default.
• W1968562444 cites W2017434636 @default.
• W1968562444 cites W2025415508 @default.
• W1968562444 cites W2029080338 @default.
• W1968562444 cites W2029714766 @default.
• W1968562444 cites W2042168852 @default.
• W1968562444 cites W2050186221 @default.
• W1968562444 cites W2050547995 @default.
• W1968562444 cites W2052192720 @default.
• W1968562444 cites W2056777828 @default.
• W1968562444 cites W2056807656 @default.
• W1968562444 cites W2058348424 @default.
• W1968562444 cites W2058784564 @default.
• W1968562444 cites W2071252006 @default.
• W1968562444 cites W2083584983 @default.
• W1968562444 cites W2084445306 @default.
• W1968562444 cites W2087096498 @default.
• W1968562444 cites W2092226234 @default.
• W1968562444 cites W2111976640 @default.
• W1968562444 cites W2132864109 @default.
• W1968562444 cites W2135212506 @default.
• W1968562444 cites W2152238532 @default.
• W1968562444 cites W2170157144 @default.
• W1968562444 cites W2318608307 @default.
• W1968562444 cites W34419914 @default.
• W1968562444 cites W4205490020 @default.
• W1968562444 doi "https://doi.org/10.1021/ja8015022" @default.
• W1968562444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2526315" @default.
• W1968562444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18557614" @default.
• W1968562444 hasPublicationYear "2008" @default.
• W1968562444 type Work @default.
• W1968562444 sameAs 1968562444 @default.
• W1968562444 citedByCount "477" @default.
• W1968562444 countsByYear W19685624442012 @default.
• W1968562444 countsByYear W19685624442013 @default.
• W1968562444 countsByYear W19685624442014 @default.
• W1968562444 countsByYear W19685624442015 @default.
• W1968562444 countsByYear W19685624442016 @default.
• W1968562444 countsByYear W19685624442017 @default.
• W1968562444 countsByYear W19685624442018 @default.
• W1968562444 countsByYear W19685624442019 @default.
• W1968562444 countsByYear W19685624442020 @default.
• W1968562444 countsByYear W19685624442021 @default.
• W1968562444 countsByYear W19685624442022 @default.
• W1968562444 countsByYear W19685624442023 @default.
• W1968562444 crossrefType "journal-article" @default.
• W1968562444 hasAuthorship W1968562444A5004453425 @default.
• W1968562444 hasAuthorship W1968562444A5004898072 @default.
• W1968562444 hasAuthorship W1968562444A5025642382 @default.
• W1968562444 hasAuthorship W1968562444A5029736335 @default.
• W1968562444 hasAuthorship W1968562444A5037587624 @default.
• W1968562444 hasAuthorship W1968562444A5038208939 @default.
• W1968562444 hasAuthorship W1968562444A5072235685 @default.
• W1968562444 hasAuthorship W1968562444A5072515852 @default.
• W1968562444 hasAuthorship W1968562444A5080438741 @default.
• W1968562444 hasAuthorship W1968562444A5087283200 @default.
• W1968562444 hasBestOaLocation W19685624442 @default.
• W1968562444 hasConcept C114614502 @default.
• W1968562444 hasConcept C121608353 @default.
• W1968562444 hasConcept C126322002 @default.
• W1968562444 hasConcept C131540310 @default.
• W1968562444 hasConcept C136229726 @default.
• W1968562444 hasConcept C147789679 @default.
• W1968562444 hasConcept C156340839 @default.
• W1968562444 hasConcept C1621761 @default.
• W1968562444 hasConcept C171250308 @default.
• W1968562444 hasConcept C178790620 @default.
• W1968562444 hasConcept C185592680 @default.
• W1968562444 hasConcept C192562407 @default.
• W1968562444 hasConcept C203014093 @default.
• W1968562444 hasConcept C2779013556 @default.
• W1968562444 hasConcept C33923547 @default.
• W1968562444 hasConcept C49040817 @default.
• W1968562444 hasConcept C521977710 @default.

• next