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- W1968574870 abstract "We have investigated the interaction of VIP and secretin with two human lung carcinoma cell lines in cultures, SW-900 and Calu-1. 125I-labeled VIP binds to and is inactivated by SW-900 and Calu-1 cells in a time- and temperature-dependent manner. The rates of binding and of inactivation were higher at 30°C than at 15°C. At equilibrium, native VIP competitively inhibited the binding of 125I-VIP in the 10−10−10−7M range, half-maximal inhibition being observed at 1.2 nM in SW-900 cells and at 1.1 nM VIP in Calu-1 cells. Scatchard analysis indicated two classes of binding sites with similar characteristics in both cell lines. SW-900 cells have 27 600 sites with a high affinity (Kd = 0.34 nM) and 1062 000 sites with a low affinity (Kd = 61.4 nM). Calu-1 cells have 36 300 sites with a high affinity (Kd = 0.33 nM) and 1148 000 sites with a low affinity (Kd = 78.6 nM). Secretin inhibited tracer binding but with a 5000 times lower potency than native VIP in both cell lines." @default.
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- W1968574870 date "1981-08-01" @default.
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- W1968574870 title "Peptide receptors in human lung tumor cells in culture: Vasoactive intestinal peptide (VIP) and secretin interaction with the Calu-1 and SW-900 cell lines" @default.
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- W1968574870 doi "https://doi.org/10.1016/0167-0115(81)90026-4" @default.
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