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- W1968580023 abstract "Increased cell expression of matrix metalloproteinase-9 (MMP-9) was associated with the development of atherosclerosis and osseoarticular tissue destruction in hemodialysis patients. In this study, the pre- and post-HD plasma concentrations of type IV collagenases and their inhibitors in HD patients were examined.Commercial ELISA kits and Zymography techniques were used to assay the parameters in 40 patients pre- and post-HD session.After the hemodialysis process, MMP-9, MMP-2 and TIMP-2 levels were 124 +/- 72, 706 +/- 242 and 248 +/- 90 ng/mL, significantly different from the pre-HD values (187 +/- 148, 759 +/- 304 and 43 +/- 14 ng/mL). TIMP-1 were not affected by HD. Female subjects and patients with chronic glomerulonephritis had higher TIMP-2 than their counterparts (p < 0.05). The effect of gender on MMP-2 levels was interacted with that of membrane types (p < 0.01).These results indicated that the hemodialysis process tends to decrease the overall activity of the peripheral plasma MMP system in HD patients." @default.
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- W1968580023 date "2002-07-01" @default.
- W1968580023 modified "2023-10-17" @default.
- W1968580023 title "Effect of hemodialysis on the plasma level of type IV collagenases and their inhibitors" @default.
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- W1968580023 doi "https://doi.org/10.1016/s0009-9120(02)00331-4" @default.
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