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- W1968581041 abstract "Metabotropic glutamate receptor mGluR1a was expressed in human embryonic kidney 293 cells. 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) stimulated dose-dependently, phosphoinositide (PI) hydrolysis in transfected, but not in non-transfected cells. The polyamine spermine did not affect PI hydrolysis in the absence of 1S,3R-ACPD even at a concentration of 1 mM, but it potentiated the stimulatory action of 1S,3R-ACPD at 10 microM. The modulatory action of spermine was mimicked by spermidine but not by the short polyamine putrescine." @default.
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- W1968581041 date "1993-06-01" @default.
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- W1968581041 title "Polyamines modulate the function of transfected glutamate receptor mGluR1a" @default.
- W1968581041 doi "https://doi.org/10.1097/00001756-199306000-00059" @default.
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