Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968581566> ?p ?o ?g. }
- W1968581566 endingPage "906" @default.
- W1968581566 startingPage "901" @default.
- W1968581566 abstract "Synaptic N-methyl-D-aspartate (NMDA) receptors detect coincident pre- and postsynaptic activity and play a critical role in triggering changes in synaptic strength at central synapses. Despite intensive study of synaptic plasticity, relatively little is known about the magnitude and duration of calcium accumulation caused by unitary events at individual synapses. We used fluorescence imaging to detect NMDA receptor-mediated miniature synaptic calcium transients (MSCTs) caused by spontaneous release of synaptic vesicles in dendrites of cultured hippocampal neurons. MSCTs originated focally in dendritic regions <1 microm in length and decayed with a time constant of 0.35 +/- 0.03 s. Multiple occurrences of MSCTs recorded at single sites had fluctuating amplitudes, with a coefficient of variation of 0.34. From the reduction in the spatial spread of MSCTs with decreasing concentration of indicator dye, we estimated that the dominant endogenous calcium buffer in dendrites is relatively immobile (diffusion coefficient between 10 and 50 microm(2)/s). We conclude that calcium rise caused by spontaneous quantal synaptic NMDA receptor activation (i) is variable, (ii) lasts for a time period briefer than previous measurements indicate, and (iii) is confined by endogenous calcium buffers to local dendritic regions even when synapses are not on spines." @default.
- W1968581566 created "2016-06-24" @default.
- W1968581566 creator A5005296029 @default.
- W1968581566 creator A5009264390 @default.
- W1968581566 creator A5044141636 @default.
- W1968581566 date "2000-01-18" @default.
- W1968581566 modified "2023-10-18" @default.
- W1968581566 title "Dynamics of dendritic calcium transients evoked by quantal release at excitatory hippocampal synapses" @default.
- W1968581566 cites W1498924480 @default.
- W1968581566 cites W1524901037 @default.
- W1968581566 cites W1551756182 @default.
- W1968581566 cites W1647836033 @default.
- W1968581566 cites W1670909519 @default.
- W1968581566 cites W1940417817 @default.
- W1968581566 cites W1972322271 @default.
- W1968581566 cites W1972815737 @default.
- W1968581566 cites W1976982494 @default.
- W1968581566 cites W1981597576 @default.
- W1968581566 cites W1983350404 @default.
- W1968581566 cites W1993372975 @default.
- W1968581566 cites W1994348876 @default.
- W1968581566 cites W1997105777 @default.
- W1968581566 cites W1997568797 @default.
- W1968581566 cites W1998347917 @default.
- W1968581566 cites W2006602134 @default.
- W1968581566 cites W2007263885 @default.
- W1968581566 cites W2008964647 @default.
- W1968581566 cites W2008967473 @default.
- W1968581566 cites W2011432049 @default.
- W1968581566 cites W2019106988 @default.
- W1968581566 cites W2022777861 @default.
- W1968581566 cites W2023013885 @default.
- W1968581566 cites W2023654689 @default.
- W1968581566 cites W2025596955 @default.
- W1968581566 cites W2033302498 @default.
- W1968581566 cites W2042934979 @default.
- W1968581566 cites W2049511526 @default.
- W1968581566 cites W2053457664 @default.
- W1968581566 cites W2053794249 @default.
- W1968581566 cites W2065967745 @default.
- W1968581566 cites W2069362932 @default.
- W1968581566 cites W2069536209 @default.
- W1968581566 cites W2073577145 @default.
- W1968581566 cites W2084864774 @default.
- W1968581566 cites W2092045031 @default.
- W1968581566 cites W2108809409 @default.
- W1968581566 cites W2117664079 @default.
- W1968581566 cites W2147101007 @default.
- W1968581566 cites W2165302477 @default.
- W1968581566 cites W2166090727 @default.
- W1968581566 cites W2185212694 @default.
- W1968581566 doi "https://doi.org/10.1073/pnas.97.2.901" @default.
- W1968581566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/15428" @default.
- W1968581566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10639177" @default.
- W1968581566 hasPublicationYear "2000" @default.
- W1968581566 type Work @default.
- W1968581566 sameAs 1968581566 @default.
- W1968581566 citedByCount "65" @default.
- W1968581566 countsByYear W19685815662013 @default.
- W1968581566 countsByYear W19685815662014 @default.
- W1968581566 countsByYear W19685815662015 @default.
- W1968581566 countsByYear W19685815662016 @default.
- W1968581566 countsByYear W19685815662017 @default.
- W1968581566 countsByYear W19685815662018 @default.
- W1968581566 countsByYear W19685815662020 @default.
- W1968581566 countsByYear W19685815662021 @default.
- W1968581566 countsByYear W19685815662022 @default.
- W1968581566 crossrefType "journal-article" @default.
- W1968581566 hasAuthorship W1968581566A5005296029 @default.
- W1968581566 hasAuthorship W1968581566A5009264390 @default.
- W1968581566 hasAuthorship W1968581566A5044141636 @default.
- W1968581566 hasBestOaLocation W19685815661 @default.
- W1968581566 hasConcept C112592302 @default.
- W1968581566 hasConcept C12554922 @default.
- W1968581566 hasConcept C130316041 @default.
- W1968581566 hasConcept C148762608 @default.
- W1968581566 hasConcept C148785051 @default.
- W1968581566 hasConcept C169760540 @default.
- W1968581566 hasConcept C170493617 @default.
- W1968581566 hasConcept C17077164 @default.
- W1968581566 hasConcept C174884520 @default.
- W1968581566 hasConcept C178790620 @default.
- W1968581566 hasConcept C185592680 @default.
- W1968581566 hasConcept C197341189 @default.
- W1968581566 hasConcept C25274449 @default.
- W1968581566 hasConcept C41625074 @default.
- W1968581566 hasConcept C519063684 @default.
- W1968581566 hasConcept C55493867 @default.
- W1968581566 hasConcept C67018056 @default.
- W1968581566 hasConcept C86803240 @default.
- W1968581566 hasConcept C95293801 @default.
- W1968581566 hasConcept C98229152 @default.
- W1968581566 hasConceptScore W1968581566C112592302 @default.
- W1968581566 hasConceptScore W1968581566C12554922 @default.
- W1968581566 hasConceptScore W1968581566C130316041 @default.
- W1968581566 hasConceptScore W1968581566C148762608 @default.
- W1968581566 hasConceptScore W1968581566C148785051 @default.
- W1968581566 hasConceptScore W1968581566C169760540 @default.