Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968584313> ?p ?o ?g. }
- W1968584313 endingPage "215" @default.
- W1968584313 startingPage "203" @default.
- W1968584313 abstract "Migration and contraction are fibroblast activities in scar tissue formation which may contribute towards the failure of trabeculec-tomies. We attempted to modify the migration and contraction of Tenon's capsule fibroblasts in vitro using the drugs taxol, cytochalasin B and colchicine. Migration assays were conducted in 48-well micro-chemotaxis chambers, using rabbit aqueous humour which has been previously identified as a powerful chemoattractant for Tenon's fibroblasts, and fibronectin as the stimuli for migration. All three drugs inhibited the migration of fibroblasts to both fibronectin and aqueous humour, with maximal activity seen at 10−6M (taxol), 10−5M (cytochalasin B), and 10−3M (colchicine). In a single cell contractile assay in which contraction of whole fibroblasts was initiated with exogenous adenosine triphosphate (ATP), taxol and colchicine showed anti-contractile activity, maximal at 10−5M and 10−3M respectively, but cytochalasin B was ineffective. The significance of the activities of these drugs in relation to their proposed use for improving the success of trabeculectomies is discussed." @default.
- W1968584313 created "2016-06-24" @default.
- W1968584313 creator A5043640338 @default.
- W1968584313 creator A5043672470 @default.
- W1968584313 creator A5067671671 @default.
- W1968584313 date "1989-01-01" @default.
- W1968584313 modified "2023-09-23" @default.
- W1968584313 title "Taxol, cytochalasin B and colchicine effects on fibroblast migration and contraction: a role in glaucoma filtration surgery?" @default.
- W1968584313 cites W1963713424 @default.
- W1968584313 cites W1969458984 @default.
- W1968584313 cites W1977296118 @default.
- W1968584313 cites W1986311374 @default.
- W1968584313 cites W1996021475 @default.
- W1968584313 cites W1999621688 @default.
- W1968584313 cites W2006432488 @default.
- W1968584313 cites W2008190738 @default.
- W1968584313 cites W2025135407 @default.
- W1968584313 cites W2026528686 @default.
- W1968584313 cites W2032537615 @default.
- W1968584313 cites W2037490361 @default.
- W1968584313 cites W2045039087 @default.
- W1968584313 cites W2060979063 @default.
- W1968584313 cites W2065498040 @default.
- W1968584313 cites W2073265552 @default.
- W1968584313 cites W2078398733 @default.
- W1968584313 cites W2089331102 @default.
- W1968584313 cites W2111205036 @default.
- W1968584313 cites W2117228071 @default.
- W1968584313 cites W2121844839 @default.
- W1968584313 cites W2137598070 @default.
- W1968584313 cites W2165721443 @default.
- W1968584313 doi "https://doi.org/10.3109/02713688908995193" @default.
- W1968584313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2565797" @default.
- W1968584313 hasPublicationYear "1989" @default.
- W1968584313 type Work @default.
- W1968584313 sameAs 1968584313 @default.
- W1968584313 citedByCount "31" @default.
- W1968584313 countsByYear W19685843132013 @default.
- W1968584313 countsByYear W19685843132016 @default.
- W1968584313 countsByYear W19685843132019 @default.
- W1968584313 crossrefType "journal-article" @default.
- W1968584313 hasAuthorship W1968584313A5043640338 @default.
- W1968584313 hasAuthorship W1968584313A5043672470 @default.
- W1968584313 hasAuthorship W1968584313A5067671671 @default.
- W1968584313 hasConcept C126322002 @default.
- W1968584313 hasConcept C134018914 @default.
- W1968584313 hasConcept C137738243 @default.
- W1968584313 hasConcept C142669718 @default.
- W1968584313 hasConcept C1491633281 @default.
- W1968584313 hasConcept C163415756 @default.
- W1968584313 hasConcept C170493617 @default.
- W1968584313 hasConcept C185592680 @default.
- W1968584313 hasConcept C202751555 @default.
- W1968584313 hasConcept C2775995422 @default.
- W1968584313 hasConcept C2776636253 @default.
- W1968584313 hasConcept C2776861759 @default.
- W1968584313 hasConcept C2779012151 @default.
- W1968584313 hasConcept C2780381497 @default.
- W1968584313 hasConcept C54166955 @default.
- W1968584313 hasConcept C55493867 @default.
- W1968584313 hasConcept C71924100 @default.
- W1968584313 hasConcept C86492073 @default.
- W1968584313 hasConcept C86803240 @default.
- W1968584313 hasConcept C95444343 @default.
- W1968584313 hasConcept C98274493 @default.
- W1968584313 hasConceptScore W1968584313C126322002 @default.
- W1968584313 hasConceptScore W1968584313C134018914 @default.
- W1968584313 hasConceptScore W1968584313C137738243 @default.
- W1968584313 hasConceptScore W1968584313C142669718 @default.
- W1968584313 hasConceptScore W1968584313C1491633281 @default.
- W1968584313 hasConceptScore W1968584313C163415756 @default.
- W1968584313 hasConceptScore W1968584313C170493617 @default.
- W1968584313 hasConceptScore W1968584313C185592680 @default.
- W1968584313 hasConceptScore W1968584313C202751555 @default.
- W1968584313 hasConceptScore W1968584313C2775995422 @default.
- W1968584313 hasConceptScore W1968584313C2776636253 @default.
- W1968584313 hasConceptScore W1968584313C2776861759 @default.
- W1968584313 hasConceptScore W1968584313C2779012151 @default.
- W1968584313 hasConceptScore W1968584313C2780381497 @default.
- W1968584313 hasConceptScore W1968584313C54166955 @default.
- W1968584313 hasConceptScore W1968584313C55493867 @default.
- W1968584313 hasConceptScore W1968584313C71924100 @default.
- W1968584313 hasConceptScore W1968584313C86492073 @default.
- W1968584313 hasConceptScore W1968584313C86803240 @default.
- W1968584313 hasConceptScore W1968584313C95444343 @default.
- W1968584313 hasConceptScore W1968584313C98274493 @default.
- W1968584313 hasIssue "2" @default.
- W1968584313 hasLocation W19685843131 @default.
- W1968584313 hasLocation W19685843132 @default.
- W1968584313 hasOpenAccess W1968584313 @default.
- W1968584313 hasPrimaryLocation W19685843131 @default.
- W1968584313 hasRelatedWork W1968584313 @default.
- W1968584313 hasRelatedWork W1994164677 @default.
- W1968584313 hasRelatedWork W2013593126 @default.
- W1968584313 hasRelatedWork W2034730440 @default.
- W1968584313 hasRelatedWork W2130953147 @default.
- W1968584313 hasRelatedWork W2159559181 @default.
- W1968584313 hasRelatedWork W2361601395 @default.