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• W1968592008 abstract "A 96-member “pyridine” library consisting of both rationally chosen and “random” members was used to screen Ullmann ether forming reactions. The reaction of 2-bromo-4,6-dimethylaniline and other substrates with a variety of alkoxides was investigated under different conditions with the aid of an automated liquid handler. From the results of the 96-member library screening, a structure activity profile was determined which led to the design of smaller “focused” ligand libraries. The focused libraries produced a higher frequency of hits compared to the original 96-member library. Some of the more effective ligands discovered in this work were found to be generally useful for alkoxylation of a variety of substrates, and also functioned in intramolecular ether forming reactions. This work demonstrates for homogeneous catalysis the analogy to the pharmacological model of drug discovery. By using a large library to screen for a lead compound followed by screening the diversity space closest to the lead, a larger fraction of increased performance ligands was discovered." @default.
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• W1968592008 date "2000-05-01" @default.
• W1968592008 modified "2023-10-16" @default.
• W1968592008 title "Using Intelligent/Random Library Screening To Design Focused Libraries for the Optimization of Homogeneous Catalysts: Ullmann Ether Formation" @default.
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• W1968592008 doi "https://doi.org/10.1021/ja000094c" @default.
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