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• W1968594529 abstract "The optimal shapes attained by contractile cells on adhesive substrates are determined by the interplay between intracellular forces and adhesion with the extracellular matrix. We model the cell as a contractile film bounded by an elastic cortex and connected to the substrate via elastic links. When the adhesion sites are continuously distributed, optimal cell shape is constrained by the adhesion geometry, with a spread area sensitively dependent on the substrate stiffness and contractile tension. For discrete adhesion sites, equilibrium cell shape is convex at weak contractility, while developing local concavities at intermediate values of contractility. Increasing contractility beyond a critical value, controlled by mechanical and geometrical properties of adhesion, cell boundary undergoes a discontinuous transition to a star-shaped configuration with cusps and protrusions, accompanied by a region of bistability and hysteresis." @default.
• W1968594529 created "2016-06-24" @default.
• W1968594529 creator A5048473878 @default.
• W1968594529 creator A5070376252 @default.
• W1968594529 date "2013-01-01" @default.
• W1968594529 modified "2023-10-01" @default.
• W1968594529 title "Polymorphism and bistability in adherent cells" @default.
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• W1968594529 doi "https://doi.org/10.1039/c3sm27791g" @default.
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