FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968621874> ?p ?o ?g. }

• W1968621874 endingPage "744" @default.
• W1968621874 startingPage "739" @default.
• W1968621874 abstract "Carbamazepine (CBZ) is one of the most commonly prescribed antiepileptic drugs (AEDs). However, a higher rate of congenital anomalies has been found in infants of mothers treated with CBZ during early pregnancy. Here, we characterize the effects of CBZ using a mouse ES cell differentiation system. The analysis of tissue-specific gene markers showed that CBZ induced early endodermal and mesodermal differentiation but inhibited differentiation of later stages. CBZ also induced ectodermal development, and there was evidence of neural differentiation as ES cells with an immature neuronal phenotype were observed. In contrast, valproic acid (VPA), another anticonvulsant drug, was previously shown to be able to induce ES cells to differentiate into neurons with a mature appearance. CBZ was less cytotoxic to ES cells than VPA. The in vitro ES cell assay system has the potential to provide a rapid and accurate approach for estimating the in vivo embryotoxicity of therapeutic drugs." @default.
• W1968621874 created "2016-06-24" @default.
• W1968621874 creator A5001561113 @default.
• W1968621874 creator A5011811795 @default.
• W1968621874 creator A5027742984 @default.
• W1968621874 creator A5047003541 @default.
• W1968621874 creator A5062372400 @default.
• W1968621874 creator A5065491742 @default.
• W1968621874 creator A5071195833 @default.
• W1968621874 date "2007-05-01" @default.
• W1968621874 modified "2023-09-26" @default.
• W1968621874 title "Estimation of the embryotoxic effect of CBZ using an ES cell differentiation system" @default.
• W1968621874 cites W1963845179 @default.
• W1968621874 cites W1967931372 @default.
• W1968621874 cites W1971334707 @default.
• W1968621874 cites W1988671949 @default.
• W1968621874 cites W2002698073 @default.
• W1968621874 cites W2012506172 @default.
• W1968621874 cites W2023938914 @default.
• W1968621874 cites W2047732548 @default.
• W1968621874 cites W2050528128 @default.
• W1968621874 cites W2051047506 @default.
• W1968621874 cites W2070781700 @default.
• W1968621874 cites W2087831413 @default.
• W1968621874 cites W2088127455 @default.
• W1968621874 cites W2098249941 @default.
• W1968621874 cites W2102023851 @default.
• W1968621874 cites W2114918609 @default.
• W1968621874 cites W2117691193 @default.
• W1968621874 cites W2124877697 @default.
• W1968621874 cites W2160810018 @default.
• W1968621874 cites W2163848795 @default.
• W1968621874 cites W4251934001 @default.
• W1968621874 doi "https://doi.org/10.1016/j.bbrc.2007.03.063" @default.
• W1968621874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17382902" @default.
• W1968621874 hasPublicationYear "2007" @default.
• W1968621874 type Work @default.
• W1968621874 sameAs 1968621874 @default.
• W1968621874 citedByCount "24" @default.
• W1968621874 countsByYear W19686218742012 @default.
• W1968621874 countsByYear W19686218742013 @default.
• W1968621874 countsByYear W19686218742014 @default.
• W1968621874 countsByYear W19686218742016 @default.
• W1968621874 countsByYear W19686218742017 @default.
• W1968621874 countsByYear W19686218742018 @default.
• W1968621874 countsByYear W19686218742019 @default.
• W1968621874 countsByYear W19686218742022 @default.
• W1968621874 countsByYear W19686218742023 @default.
• W1968621874 crossrefType "journal-article" @default.
• W1968621874 hasAuthorship W1968621874A5001561113 @default.
• W1968621874 hasAuthorship W1968621874A5011811795 @default.
• W1968621874 hasAuthorship W1968621874A5027742984 @default.
• W1968621874 hasAuthorship W1968621874A5047003541 @default.
• W1968621874 hasAuthorship W1968621874A5062372400 @default.
• W1968621874 hasAuthorship W1968621874A5065491742 @default.
• W1968621874 hasAuthorship W1968621874A5071195833 @default.
• W1968621874 hasConcept C104317684 @default.
• W1968621874 hasConcept C127716648 @default.
• W1968621874 hasConcept C148738053 @default.
• W1968621874 hasConcept C1491633281 @default.
• W1968621874 hasConcept C169760540 @default.
• W1968621874 hasConcept C185592680 @default.
• W1968621874 hasConcept C202751555 @default.
• W1968621874 hasConcept C207001950 @default.
• W1968621874 hasConcept C2775858608 @default.
• W1968621874 hasConcept C2777172819 @default.
• W1968621874 hasConcept C2778186239 @default.
• W1968621874 hasConcept C2779253243 @default.
• W1968621874 hasConcept C2780035454 @default.
• W1968621874 hasConcept C2910797910 @default.
• W1968621874 hasConcept C54355233 @default.
• W1968621874 hasConcept C55493867 @default.
• W1968621874 hasConcept C86803240 @default.
• W1968621874 hasConcept C95444343 @default.
• W1968621874 hasConcept C98274493 @default.
• W1968621874 hasConceptScore W1968621874C104317684 @default.
• W1968621874 hasConceptScore W1968621874C127716648 @default.
• W1968621874 hasConceptScore W1968621874C148738053 @default.
• W1968621874 hasConceptScore W1968621874C1491633281 @default.
• W1968621874 hasConceptScore W1968621874C169760540 @default.
• W1968621874 hasConceptScore W1968621874C185592680 @default.
• W1968621874 hasConceptScore W1968621874C202751555 @default.
• W1968621874 hasConceptScore W1968621874C207001950 @default.
• W1968621874 hasConceptScore W1968621874C2775858608 @default.
• W1968621874 hasConceptScore W1968621874C2777172819 @default.
• W1968621874 hasConceptScore W1968621874C2778186239 @default.
• W1968621874 hasConceptScore W1968621874C2779253243 @default.
• W1968621874 hasConceptScore W1968621874C2780035454 @default.
• W1968621874 hasConceptScore W1968621874C2910797910 @default.
• W1968621874 hasConceptScore W1968621874C54355233 @default.
• W1968621874 hasConceptScore W1968621874C55493867 @default.
• W1968621874 hasConceptScore W1968621874C86803240 @default.
• W1968621874 hasConceptScore W1968621874C95444343 @default.
• W1968621874 hasConceptScore W1968621874C98274493 @default.
• W1968621874 hasIssue "3" @default.
• W1968621874 hasLocation W19686218741 @default.
• W1968621874 hasLocation W19686218742 @default.
• W1968621874 hasOpenAccess W1968621874 @default.

• next