Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968629139> ?p ?o ?g. }
- W1968629139 endingPage "219" @default.
- W1968629139 startingPage "208" @default.
- W1968629139 abstract "The aim of the present work is the in depth study of the protein aggregation mechanisms of whole porcine plasma and its fractions (serum, albumin and globulins) during heating using FTIR spectroscopy. Also, 2D correlation spectroscopy (2D COS) was used to establish the sequence of events during heat-induced gelation for all fractions. The results indicate that serum albumin quickly aggregates from 70 °C through non-native intramolecular β-sheets while globulins show lower susceptibility to protein aggregation. When found together, the aggregation pattern strongly depends on the composition of the protein mixture. That makes the great difference between plasma (serum albumin + globulins + fibrinogen) and serum (serum albumin + globulins) behavior, with the aggregation degree at the end of the thermal process being enhanced in the presence of fibrinogen – and achieving a similar level to that of serum albumin – while minimized in its absence. Attending on the low content of fibrinogen in plasma, our results suggest a great fibrinogen ability to alter the thermal serum albumin and globulins behavior by modifying the negative interactions established between them when no more proteins are found in the media. Moreover, it is noteworthy the slow plasma aggregation pattern at the beginning of the thermal process relative to serum albumin, this way allowing a higher protein unfolding. This could be related to the high heat-induced gel properties of plasma. Also, 2D COS indicates that the sequence of events is very similar for the all analyzed samples, with α-helix being more thermo-labile than native β-sheet structure." @default.
- W1968629139 created "2016-06-24" @default.
- W1968629139 creator A5041997074 @default.
- W1968629139 creator A5046460943 @default.
- W1968629139 creator A5087929948 @default.
- W1968629139 date "2012-05-01" @default.
- W1968629139 modified "2023-10-10" @default.
- W1968629139 title "Heat-induced denaturation/aggregation of porcine plasma and its fractions studied by FTIR spectroscopy" @default.
- W1968629139 cites W1504792186 @default.
- W1968629139 cites W1506358009 @default.
- W1968629139 cites W1538053966 @default.
- W1968629139 cites W1544277054 @default.
- W1968629139 cites W1556587647 @default.
- W1968629139 cites W1728837791 @default.
- W1968629139 cites W1934853983 @default.
- W1968629139 cites W1964200863 @default.
- W1968629139 cites W1965668009 @default.
- W1968629139 cites W1966049316 @default.
- W1968629139 cites W1967073845 @default.
- W1968629139 cites W1974994136 @default.
- W1968629139 cites W1975372451 @default.
- W1968629139 cites W1975460989 @default.
- W1968629139 cites W1975833078 @default.
- W1968629139 cites W1976447797 @default.
- W1968629139 cites W1977310106 @default.
- W1968629139 cites W1978418542 @default.
- W1968629139 cites W1978940499 @default.
- W1968629139 cites W1979780600 @default.
- W1968629139 cites W1983607606 @default.
- W1968629139 cites W1985635711 @default.
- W1968629139 cites W1986571390 @default.
- W1968629139 cites W1988873606 @default.
- W1968629139 cites W1988981377 @default.
- W1968629139 cites W1989302692 @default.
- W1968629139 cites W1991583204 @default.
- W1968629139 cites W1992198654 @default.
- W1968629139 cites W1992659896 @default.
- W1968629139 cites W1995062321 @default.
- W1968629139 cites W1996204663 @default.
- W1968629139 cites W1996780767 @default.
- W1968629139 cites W1997069108 @default.
- W1968629139 cites W2002058880 @default.
- W1968629139 cites W2005062481 @default.
- W1968629139 cites W2006858399 @default.
- W1968629139 cites W2009581572 @default.
- W1968629139 cites W2011217599 @default.
- W1968629139 cites W2012455282 @default.
- W1968629139 cites W2018159596 @default.
- W1968629139 cites W2018617914 @default.
- W1968629139 cites W2023137747 @default.
- W1968629139 cites W2024709897 @default.
- W1968629139 cites W2025071517 @default.
- W1968629139 cites W2025402276 @default.
- W1968629139 cites W2025494960 @default.
- W1968629139 cites W2026232127 @default.
- W1968629139 cites W2026923622 @default.
- W1968629139 cites W2030621649 @default.
- W1968629139 cites W2031775243 @default.
- W1968629139 cites W2032760893 @default.
- W1968629139 cites W2035491839 @default.
- W1968629139 cites W2037852107 @default.
- W1968629139 cites W2038396939 @default.
- W1968629139 cites W2038560836 @default.
- W1968629139 cites W2040049703 @default.
- W1968629139 cites W2040211368 @default.
- W1968629139 cites W2042391719 @default.
- W1968629139 cites W2042465367 @default.
- W1968629139 cites W2042536459 @default.
- W1968629139 cites W2045487874 @default.
- W1968629139 cites W2045923115 @default.
- W1968629139 cites W2049576062 @default.
- W1968629139 cites W2050737292 @default.
- W1968629139 cites W2051189365 @default.
- W1968629139 cites W2052068815 @default.
- W1968629139 cites W2055565251 @default.
- W1968629139 cites W2059035251 @default.
- W1968629139 cites W2060042595 @default.
- W1968629139 cites W2061213777 @default.
- W1968629139 cites W2062102053 @default.
- W1968629139 cites W2067129761 @default.
- W1968629139 cites W2067474488 @default.
- W1968629139 cites W2068125421 @default.
- W1968629139 cites W2071114991 @default.
- W1968629139 cites W2075391907 @default.
- W1968629139 cites W2075879075 @default.
- W1968629139 cites W2076334645 @default.
- W1968629139 cites W2076663462 @default.
- W1968629139 cites W2077727566 @default.
- W1968629139 cites W2083523676 @default.
- W1968629139 cites W2083563479 @default.
- W1968629139 cites W2088538995 @default.
- W1968629139 cites W2088709410 @default.
- W1968629139 cites W2089441641 @default.
- W1968629139 cites W2090413444 @default.
- W1968629139 cites W2092356072 @default.
- W1968629139 cites W2102231003 @default.
- W1968629139 cites W2102264945 @default.
- W1968629139 cites W2124505724 @default.