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• W1968648699 abstract "MELAS is a common mitochondrial disease frequently associated with the m.3243A>G point mutation in the tRNALeu(UUR) of mitochondrial DNA and characterized by stroke-like episodes with vasogenic edema and lactic acidosis. The pathogenic mechanism of stroke and brain edema is not known. Alterations in the blood brain barrier (BBB) caused by respiratory chain defects in the cortical microvessels could explain the pathogenesis. To test this hypothesis we developed a tissue culture model of the human BBB. The MELAS mutation was introduced into immortalized brain capillary endothelial cells and astrocytes. Respiratory chain activity and transendothelial electrical resistance, TEER was measured. Severe defects of respiratory chain complex I and IV activities, and a moderate deficiency of complex II activity in cells harboring the MELAS mutation were associated with low TEER, indicating that the integrity of the BBB was compromised. These data support our hypothesis that respiratory chain defects in the components of the BBB cause changes in permeability." @default.
• W1968648699 created "2016-06-24" @default.
• W1968648699 creator A5019742604 @default.
• W1968648699 creator A5028069257 @default.
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• W1968648699 date "2009-11-01" @default.
• W1968648699 modified "2023-10-16" @default.
• W1968648699 title "The m.3243A>G mtDNA mutation is pathogenic in an in vitro model of the human blood brain barrier" @default.
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• W1968648699 doi "https://doi.org/10.1016/j.mito.2009.08.006" @default.
• W1968648699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2783492" @default.
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