FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968651937> ?p ?o ?g. }

• W1968651937 endingPage "S99" @default.
• W1968651937 startingPage "S98" @default.
• W1968651937 abstract "Purpose: To evaluate the influence of chemoradiation with full–dose chemotherapy and 3D optimized image-guided brachytherapy on clinical efficiacy and treatment safety in patients with advanced cervical cancer. Materials and Methods: 112 pts., 16–67 y.o., T2a–3bN0–1Mo, underwent pelvic irradiation after [78 (69.6%) – group I] or concomitantly [34 (30.4%) – group II ] with full–dose chemotherapy(CHT), cis–carboplatinum, taxans, gemcytabine, 5FU, Cyclophosphamide, Bleomycin, Doxorubicin in 2–4 drug combinations, 2 cycles in 87%. 14 (12.5%) LN–positive pts. received paraaortic irradiation. 2D–3D and Doppler ultrasound was used for HR–CTV monitoring. CT- and MRI-based 192Ir HDR brachytherapy was done D90 5–6 Gy twice a week along with EBRT parametrium irradiation. DVH-based 3D optimization was done the square of bladder posterior wall, included in D100, D90, D80, and mean and maximum dose in vesical triangle were measured to detail bladder tolerance level. Results: After neoadjuvant chemotherapy in Group I no CR, PR >75% –12.8%, progression – 17.9% were registered, but TD to whole pelvis before brachytherapy with adequate tandem application was reliably lower in group I versus group II: 14–16 Gy – 11.5% vs 11.8%; 18–24 Gy – 60.3% vs 29.4%; 26–40 Gy – 28.2% vs 58.8%. In whole, pre–planned course of chemoradiation was completed successfully in 104 (92.8%) [I–74 (94.9%), II – 30 (88.2%)] with HR–CTV doses lower in group I vs group II: 62–66 Gy – 42.3% vs 17.6%, 67–70 Gy – 39.7% vs 52.9%, 71–75 Gy – 12.8% vs 23.5%, 76–81 Gy – 5.1% vs 5.8%. Treatment was safe in both groups, more tolerable in group I vs group II (no breaks: 25.6% vs 5.8%; break duration 7 ± 3.4 vs 12.5 ± 5.4 days, toxicity 3 II grade RTOG in bladder 15.4% vs 23.5%, intestinum 17.1% vs 41.1%, hematologic – 32.1% vs 73.5%. 5-year OS 88 (75.9%) [I- 62 (79.8%), II – 23 (67.6%)], DFS 81 (72.3%) [I– 60 (76.9%), II – 21 (62.4%)], no late complications Grade III-IV EORTC. Conclusions: In locally advanced cervical cancer patients neoadjuvant chemotherapy allows to reduce significantly GTV, HR-CTV and OAR irradiated volumes before brachytherapy to ensure adequate tandem positioning and dose minimization in OAR; concomitant chemoradiation with full-dose chemotherapy doesn’t increase significantly speed and volume of tumor regression before brachytherapy. Image-guided brachytherapy with 3D DVH-based dose optimization allows to concentrate doses in target with maximal sparing of bladder, rectum and sigmoid, so optimal HR-CTV and IR-CTV doses for full-dose chemotherapy chemoradiation programs should be specify in additional trials. 10–15% increase of target dose and new cytotoxic drugs synthesis with moderate haematological, gastro-intestinal and urological toxicity are the most real ways to improve the results of locally advanced cervical cancer treatment." @default.
• W1968651937 created "2016-06-24" @default.
• W1968651937 creator A5042266331 @default.
• W1968651937 creator A5058391832 @default.
• W1968651937 creator A5070041772 @default.
• W1968651937 date "2011-05-01" @default.
• W1968651937 modified "2023-09-25" @default.
• W1968651937 title "Image-Guided 3D-Optimized Brachytherapy in Full-Dose Chemoradiation Programs of Advanced Cervical Cancer Primary Treatment" @default.
• W1968651937 doi "https://doi.org/10.1016/j.brachy.2011.02.204" @default.
• W1968651937 hasPublicationYear "2011" @default.
• W1968651937 type Work @default.
• W1968651937 sameAs 1968651937 @default.
• W1968651937 citedByCount "0" @default.
• W1968651937 crossrefType "journal-article" @default.
• W1968651937 hasAuthorship W1968651937A5042266331 @default.
• W1968651937 hasAuthorship W1968651937A5058391832 @default.
• W1968651937 hasAuthorship W1968651937A5070041772 @default.
• W1968651937 hasBestOaLocation W19686519371 @default.
• W1968651937 hasConcept C121608353 @default.
• W1968651937 hasConcept C126322002 @default.
• W1968651937 hasConcept C126838900 @default.
• W1968651937 hasConcept C126894567 @default.
• W1968651937 hasConcept C141071460 @default.
• W1968651937 hasConcept C2776232574 @default.
• W1968651937 hasConcept C2776694085 @default.
• W1968651937 hasConcept C2777416452 @default.
• W1968651937 hasConcept C2778220009 @default.
• W1968651937 hasConcept C2778357063 @default.
• W1968651937 hasConcept C2779808985 @default.
• W1968651937 hasConcept C2989005 @default.
• W1968651937 hasConcept C509974204 @default.
• W1968651937 hasConcept C71924100 @default.
• W1968651937 hasConceptScore W1968651937C121608353 @default.
• W1968651937 hasConceptScore W1968651937C126322002 @default.
• W1968651937 hasConceptScore W1968651937C126838900 @default.
• W1968651937 hasConceptScore W1968651937C126894567 @default.
• W1968651937 hasConceptScore W1968651937C141071460 @default.
• W1968651937 hasConceptScore W1968651937C2776232574 @default.
• W1968651937 hasConceptScore W1968651937C2776694085 @default.
• W1968651937 hasConceptScore W1968651937C2777416452 @default.
• W1968651937 hasConceptScore W1968651937C2778220009 @default.
• W1968651937 hasConceptScore W1968651937C2778357063 @default.
• W1968651937 hasConceptScore W1968651937C2779808985 @default.
• W1968651937 hasConceptScore W1968651937C2989005 @default.
• W1968651937 hasConceptScore W1968651937C509974204 @default.
• W1968651937 hasConceptScore W1968651937C71924100 @default.
• W1968651937 hasLocation W19686519371 @default.
• W1968651937 hasOpenAccess W1968651937 @default.
• W1968651937 hasPrimaryLocation W19686519371 @default.
• W1968651937 hasRelatedWork W1969591107 @default.
• W1968651937 hasRelatedWork W1982056677 @default.
• W1968651937 hasRelatedWork W2048191766 @default.
• W1968651937 hasRelatedWork W2375972554 @default.
• W1968651937 hasRelatedWork W2384708512 @default.
• W1968651937 hasRelatedWork W2404243584 @default.
• W1968651937 hasRelatedWork W2437812263 @default.
• W1968651937 hasRelatedWork W2966036943 @default.
• W1968651937 hasRelatedWork W3104537559 @default.
• W1968651937 hasRelatedWork W4206581437 @default.
• W1968651937 hasVolume "10" @default.
• W1968651937 isParatext "false" @default.
• W1968651937 isRetracted "false" @default.
• W1968651937 magId "1968651937" @default.
• W1968651937 workType "article" @default.