FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968654211> ?p ?o ?g. }

• W1968654211 endingPage "129" @default.
• W1968654211 startingPage "123" @default.
• W1968654211 abstract "Disintegrins and disintegrins-like proteins are able to inhibit platelet aggregation and integrin-mediated cell adhesion. The aim of this study was to produce one disintegrin-like cloned from Bothrops leucurus venom gland and to characterize it regarding biological activity. The recombinant protein was purified by one step procedure involving anion-exchange chromatography (DEAE-cellulose) and presented a molecular mass of 10.4 kDa. The purified protein was able to inhibit platelet aggregation induced by collagen (IC50 = 0.65 μM) and to inhibit growth of Ehrlich tumor implanted in mice by more than 50% after 7 days administration of 10 μg/day. No effects were observed upon adenosine 5′-diphosphate (ADP)-and arachidonic acid (AA)-induced platelet aggregation. The recombinant protein was recognized by an antibody specific for jararhagin one metalloproteinase isolated from Bothrops jararaca venom, and therefore it was named leucurogin. Anti-angiogenesis effect of leucurogin was evaluated by the sponge implant model. After 7 days administration leucurogin inhibited, in a dose dependent way, the vascularization process in the sponge. Leucurogin represents a new biotechnological tool to understand biological processes where disintegrins-like are involved and may help to characterize integrins that can be involved in development and progression of malignant cells." @default.
• W1968654211 created "2016-06-24" @default.
• W1968654211 creator A5015894402 @default.
• W1968654211 creator A5033536531 @default.
• W1968654211 creator A5038260780 @default.
• W1968654211 creator A5039615890 @default.
• W1968654211 creator A5041948340 @default.
• W1968654211 creator A5064446187 @default.
• W1968654211 creator A5073868984 @default.
• W1968654211 creator A5078714398 @default.
• W1968654211 creator A5087534313 @default.
• W1968654211 creator A5090844035 @default.
• W1968654211 date "2011-07-01" @default.
• W1968654211 modified "2023-10-18" @default.
• W1968654211 title "Leucurogin, a new recombinant disintegrin cloned from Bothrops leucurus (white-tailed-jararaca) with potent activity upon platelet aggregation and tumor growth" @default.
• W1968654211 cites W1532085934 @default.
• W1968654211 cites W1964799347 @default.
• W1968654211 cites W1967080411 @default.
• W1968654211 cites W1982245129 @default.
• W1968654211 cites W1996830543 @default.
• W1968654211 cites W2000001290 @default.
• W1968654211 cites W2009942259 @default.
• W1968654211 cites W2012558411 @default.
• W1968654211 cites W2012601549 @default.
• W1968654211 cites W2020921331 @default.
• W1968654211 cites W2022619070 @default.
• W1968654211 cites W2022957695 @default.
• W1968654211 cites W2025571081 @default.
• W1968654211 cites W2028590427 @default.
• W1968654211 cites W2034956882 @default.
• W1968654211 cites W2041444313 @default.
• W1968654211 cites W2043381167 @default.
• W1968654211 cites W2049127003 @default.
• W1968654211 cites W2054257708 @default.
• W1968654211 cites W2055785948 @default.
• W1968654211 cites W2061852709 @default.
• W1968654211 cites W2107490144 @default.
• W1968654211 cites W2115395172 @default.
• W1968654211 cites W2115411982 @default.
• W1968654211 cites W2126369283 @default.
• W1968654211 cites W2137882233 @default.
• W1968654211 cites W2143869737 @default.
• W1968654211 cites W4232534952 @default.
• W1968654211 cites W4293247451 @default.
• W1968654211 doi "https://doi.org/10.1016/j.toxicon.2011.05.013" @default.
• W1968654211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21641921" @default.
• W1968654211 hasPublicationYear "2011" @default.
• W1968654211 type Work @default.
• W1968654211 sameAs 1968654211 @default.
• W1968654211 citedByCount "28" @default.
• W1968654211 countsByYear W19686542112012 @default.
• W1968654211 countsByYear W19686542112013 @default.
• W1968654211 countsByYear W19686542112014 @default.
• W1968654211 countsByYear W19686542112015 @default.
• W1968654211 countsByYear W19686542112016 @default.
• W1968654211 countsByYear W19686542112017 @default.
• W1968654211 countsByYear W19686542112018 @default.
• W1968654211 countsByYear W19686542112019 @default.
• W1968654211 countsByYear W19686542112020 @default.
• W1968654211 countsByYear W19686542112021 @default.
• W1968654211 countsByYear W19686542112022 @default.
• W1968654211 countsByYear W19686542112023 @default.
• W1968654211 crossrefType "journal-article" @default.
• W1968654211 hasAuthorship W1968654211A5015894402 @default.
• W1968654211 hasAuthorship W1968654211A5033536531 @default.
• W1968654211 hasAuthorship W1968654211A5038260780 @default.
• W1968654211 hasAuthorship W1968654211A5039615890 @default.
• W1968654211 hasAuthorship W1968654211A5041948340 @default.
• W1968654211 hasAuthorship W1968654211A5064446187 @default.
• W1968654211 hasAuthorship W1968654211A5073868984 @default.
• W1968654211 hasAuthorship W1968654211A5078714398 @default.
• W1968654211 hasAuthorship W1968654211A5087534313 @default.
• W1968654211 hasAuthorship W1968654211A5090844035 @default.
• W1968654211 hasBestOaLocation W19686542111 @default.
• W1968654211 hasConcept C104317684 @default.
• W1968654211 hasConcept C109523444 @default.
• W1968654211 hasConcept C1491633281 @default.
• W1968654211 hasConcept C153911025 @default.
• W1968654211 hasConcept C185592680 @default.
• W1968654211 hasConcept C195687474 @default.
• W1968654211 hasConcept C2776725428 @default.
• W1968654211 hasConcept C2778259572 @default.
• W1968654211 hasConcept C2779448229 @default.
• W1968654211 hasConcept C2909919539 @default.
• W1968654211 hasConcept C40767141 @default.
• W1968654211 hasConcept C55493867 @default.
• W1968654211 hasConcept C55728118 @default.
• W1968654211 hasConcept C86803240 @default.
• W1968654211 hasConcept C95444343 @default.
• W1968654211 hasConceptScore W1968654211C104317684 @default.
• W1968654211 hasConceptScore W1968654211C109523444 @default.
• W1968654211 hasConceptScore W1968654211C1491633281 @default.
• W1968654211 hasConceptScore W1968654211C153911025 @default.
• W1968654211 hasConceptScore W1968654211C185592680 @default.
• W1968654211 hasConceptScore W1968654211C195687474 @default.
• W1968654211 hasConceptScore W1968654211C2776725428 @default.
• W1968654211 hasConceptScore W1968654211C2778259572 @default.
• W1968654211 hasConceptScore W1968654211C2779448229 @default.

• next