FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968654323> ?p ?o ?g. }

• W1968654323 endingPage "11076" @default.
• W1968654323 startingPage "11070" @default.
• W1968654323 abstract "The heterodimer of Tas1R2 and Tas1R3 is a broadly acting sweet taste receptor, which mediates mammalian sweet taste toward natural and artificial sweeteners and sweet-tasting proteins. Perception of sweet taste is a species-selective physiological process. For instance, artificial sweeteners aspartame and neotame taste sweet to humans, apes, and Old World monkeys but not to New World monkeys and rodents. Although specific regions determining the activation of the receptors by these sweeteners have been identified, the molecular mechanism of species-dependent sweet taste remains elusive. Using human/squirrel monkey chimeras, mutagenesis, and molecular modeling, we reveal that the different responses of mammalian species toward the artificial sweeteners aspartame and neotame are determined by the steric effect of a combination of a few residues in the ligand binding pocket. Residues S40 and D142 in the human Tas1R2, which correspond to residues T40 and E142 in the squirrel monkey Tas1R2, were found to be the critical residues for the species-dependent difference in sweet taste. In addition, human Tas1R2 residue I67, which corresponds to S67 in squirrel monkey receptor, modulates the higher affinity of neotame than of aspartame. Our studies not only shed light on the molecular mechanism of species-dependent sweet taste toward artificial sweeteners, but also provide guidance for designing novel effective artificial sweet compounds." @default.
• W1968654323 created "2016-06-24" @default.
• W1968654323 creator A5007844508 @default.
• W1968654323 creator A5063875638 @default.
• W1968654323 creator A5070825189 @default.
• W1968654323 creator A5076914291 @default.
• W1968654323 creator A5077558876 @default.
• W1968654323 creator A5079738340 @default.
• W1968654323 creator A5085431842 @default.
• W1968654323 creator A5087424945 @default.
• W1968654323 creator A5090815103 @default.
• W1968654323 date "2011-07-27" @default.
• W1968654323 modified "2023-10-12" @default.
• W1968654323 title "Molecular Mechanism of Species-Dependent Sweet Taste toward Artificial Sweeteners" @default.
• W1968654323 cites W1945680072 @default.
• W1968654323 cites W1963506689 @default.
• W1968654323 cites W1977806455 @default.
• W1968654323 cites W1983792789 @default.
• W1968654323 cites W1998890862 @default.
• W1968654323 cites W2004264351 @default.
• W1968654323 cites W2007332013 @default.
• W1968654323 cites W2024011576 @default.
• W1968654323 cites W2029667189 @default.
• W1968654323 cites W2046325265 @default.
• W1968654323 cites W2061559673 @default.
• W1968654323 cites W2065283382 @default.
• W1968654323 cites W2071486470 @default.
• W1968654323 cites W2073115006 @default.
• W1968654323 cites W2084160726 @default.
• W1968654323 cites W2084880007 @default.
• W1968654323 cites W2089569365 @default.
• W1968654323 cites W2099666647 @default.
• W1968654323 cites W2104053777 @default.
• W1968654323 cites W2106882534 @default.
• W1968654323 cites W2114520383 @default.
• W1968654323 cites W2121145363 @default.
• W1968654323 cites W2125839878 @default.
• W1968654323 cites W2126103175 @default.
• W1968654323 cites W2140703033 @default.
• W1968654323 cites W2153839885 @default.
• W1968654323 cites W2155240946 @default.
• W1968654323 cites W2158534713 @default.
• W1968654323 cites W2162166182 @default.
• W1968654323 cites W50178793 @default.
• W1968654323 doi "https://doi.org/10.1523/jneurosci.0791-11.2011" @default.
• W1968654323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3149845" @default.
• W1968654323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21795555" @default.
• W1968654323 hasPublicationYear "2011" @default.
• W1968654323 type Work @default.
• W1968654323 sameAs 1968654323 @default.
• W1968654323 citedByCount "56" @default.
• W1968654323 countsByYear W19686543232012 @default.
• W1968654323 countsByYear W19686543232013 @default.
• W1968654323 countsByYear W19686543232014 @default.
• W1968654323 countsByYear W19686543232015 @default.
• W1968654323 countsByYear W19686543232016 @default.
• W1968654323 countsByYear W19686543232017 @default.
• W1968654323 countsByYear W19686543232018 @default.
• W1968654323 countsByYear W19686543232019 @default.
• W1968654323 countsByYear W19686543232020 @default.
• W1968654323 countsByYear W19686543232021 @default.
• W1968654323 countsByYear W19686543232022 @default.
• W1968654323 countsByYear W19686543232023 @default.
• W1968654323 crossrefType "journal-article" @default.
• W1968654323 hasAuthorship W1968654323A5007844508 @default.
• W1968654323 hasAuthorship W1968654323A5063875638 @default.
• W1968654323 hasAuthorship W1968654323A5070825189 @default.
• W1968654323 hasAuthorship W1968654323A5076914291 @default.
• W1968654323 hasAuthorship W1968654323A5077558876 @default.
• W1968654323 hasAuthorship W1968654323A5079738340 @default.
• W1968654323 hasAuthorship W1968654323A5085431842 @default.
• W1968654323 hasAuthorship W1968654323A5087424945 @default.
• W1968654323 hasAuthorship W1968654323A5090815103 @default.
• W1968654323 hasBestOaLocation W19686543231 @default.
• W1968654323 hasConcept C185592680 @default.
• W1968654323 hasConcept C2777108408 @default.
• W1968654323 hasConcept C2778278337 @default.
• W1968654323 hasConcept C2911055575 @default.
• W1968654323 hasConcept C3018655482 @default.
• W1968654323 hasConcept C55493867 @default.
• W1968654323 hasConcept C8868529 @default.
• W1968654323 hasConceptScore W1968654323C185592680 @default.
• W1968654323 hasConceptScore W1968654323C2777108408 @default.
• W1968654323 hasConceptScore W1968654323C2778278337 @default.
• W1968654323 hasConceptScore W1968654323C2911055575 @default.
• W1968654323 hasConceptScore W1968654323C3018655482 @default.
• W1968654323 hasConceptScore W1968654323C55493867 @default.
• W1968654323 hasConceptScore W1968654323C8868529 @default.
• W1968654323 hasIssue "30" @default.
• W1968654323 hasLocation W19686543231 @default.
• W1968654323 hasLocation W19686543232 @default.
• W1968654323 hasLocation W19686543233 @default.
• W1968654323 hasLocation W19686543234 @default.
• W1968654323 hasOpenAccess W1968654323 @default.
• W1968654323 hasPrimaryLocation W19686543231 @default.
• W1968654323 hasRelatedWork W1922586459 @default.
• W1968654323 hasRelatedWork W2071223548 @default.
• W1968654323 hasRelatedWork W223690179 @default.

• next