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- W1968656739 abstract "<h2>Abstract</h2> Total protein synthesis has been investigated in an in vitro system (swine aortic explants) which has many of the features of the early atherosclerotic lesion. The synthetic activity is measured by the incorporation of [<sup>14</sup>C]leucine into protein the last 2 h of a 9-day culture period. Human sera differ (up to 10-fold) in their capacity to stimulate protein synthesis, and, in addition, cause significantly greater synthesis than normal swine sera when included in the culture medium. The synthetic activity resulting from an ultrafiltrate of serum (mol. wt. 20 000) is less than that resulting from the whole serum of origin, while the recombination of dialyzed serum and dialysate results in enhanced synthesis. There is a high degree of correlation between protein and DNA synthesis measured during this 2-h interval in every experimental situation. Use of metabolic inhibitors shows that DNA synthesis can be almost completely inhibited with no such effect on protein synthesis, but inhibition of protein synthesis causes concomitant depression of DNA synthesis. The explant system may be useful in assessing the importance of the contribution of protein synthesis to the human disease picture." @default.
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- W1968656739 date "1976-03-01" @default.
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- W1968656739 title "Protein synthesis and its relation to DNA synthesis in aortic medial explants" @default.
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