FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968658549> ?p ?o ?g. }

• W1968658549 endingPage "82" @default.
• W1968658549 startingPage "77" @default.
• W1968658549 abstract "The antiserum AS7 can specifically immunoprecipitate α-Gi from membrane extracts as well as from a mixture of purified α-Gi and α-Go. as ascertained using [32P]ADP-ribosylated G-proteins. Using this antiserum to immunoprecipitate α-Gi from hepatocytes labelled with 32P it was evident that α-Gi was phosphorylated under basal (resting) conditions. Challenge of hepatocytes with the tumour promoting phorbol ester TPA, however, elicited a marked enhancement of the phosphorylation state of α-Gi. This was accompanied by the loss of inhibitory effect of Gi on adenylate cyclase, as judged by the inability of low concentrations of p[NH]ppG to inhibit forskolin-stimulated adenylate cyclase activity. Such actions were mimicked by treatment of hepatocytes with either glucagon or TH-glucagon, an analogue of glucagon which is incapable of activating adenylate cyclase and elevating intracellular cyclic AMP concentrations. Pre-treatment of hepatocytes with either glucagon, TPA or insulin did not affect the ability of pertussis toxin to cause the NAD+-dependent, [32P]ADP-ribosylation of α-Gi in membrane fractions isolated from such pre-treated hepatocytes. We suggest that protein kinase C can elicit the phosphorylation and functional inactivation of α-Gi in intact hepatocytes. As pertussis toxin only causes the ADP-ribosylation of the holomeric form of Gi, it may be that phosphorylation leaves α-Gi in its holomeric state." @default.
• W1968658549 created "2016-06-24" @default.
• W1968658549 creator A5002595618 @default.
• W1968658549 creator A5051585961 @default.
• W1968658549 creator A5055355105 @default.
• W1968658549 creator A5074737365 @default.
• W1968658549 date "1989-01-16" @default.
• W1968658549 modified "2023-09-23" @default.
• W1968658549 title "Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein G_i" @default.
• W1968658549 cites W1483853294 @default.
• W1968658549 cites W1498266611 @default.
• W1968658549 cites W1499460529 @default.
• W1968658549 cites W1532747508 @default.
• W1968658549 cites W1535986268 @default.
• W1968658549 cites W1539631646 @default.
• W1968658549 cites W1571343834 @default.
• W1968658549 cites W1600624424 @default.
• W1968658549 cites W1955944537 @default.
• W1968658549 cites W1967395137 @default.
• W1968658549 cites W1976298667 @default.
• W1968658549 cites W1978151819 @default.
• W1968658549 cites W1982690338 @default.
• W1968658549 cites W1996626314 @default.
• W1968658549 cites W1997348902 @default.
• W1968658549 cites W1997870504 @default.
• W1968658549 cites W2050807790 @default.
• W1968658549 cites W2062105646 @default.
• W1968658549 cites W2080875376 @default.
• W1968658549 cites W2082916559 @default.
• W1968658549 cites W2100837269 @default.
• W1968658549 cites W2112197155 @default.
• W1968658549 cites W2177387315 @default.
• W1968658549 cites W2236373896 @default.
• W1968658549 cites W2276786465 @default.
• W1968658549 cites W2342123394 @default.
• W1968658549 doi "https://doi.org/10.1016/0014-5793(89)81221-9" @default.
• W1968658549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2493392" @default.
• W1968658549 hasPublicationYear "1989" @default.
• W1968658549 type Work @default.
• W1968658549 sameAs 1968658549 @default.
• W1968658549 citedByCount "92" @default.
• W1968658549 crossrefType "journal-article" @default.
• W1968658549 hasAuthorship W1968658549A5002595618 @default.
• W1968658549 hasAuthorship W1968658549A5051585961 @default.
• W1968658549 hasAuthorship W1968658549A5055355105 @default.
• W1968658549 hasAuthorship W1968658549A5074737365 @default.
• W1968658549 hasConcept C11960822 @default.
• W1968658549 hasConcept C126322002 @default.
• W1968658549 hasConcept C134018914 @default.
• W1968658549 hasConcept C170493617 @default.
• W1968658549 hasConcept C180526460 @default.
• W1968658549 hasConcept C181199279 @default.
• W1968658549 hasConcept C195794163 @default.
• W1968658549 hasConcept C202751555 @default.
• W1968658549 hasConcept C2776200302 @default.
• W1968658549 hasConcept C2777006276 @default.
• W1968658549 hasConcept C2778563252 @default.
• W1968658549 hasConcept C2779276759 @default.
• W1968658549 hasConcept C2780043322 @default.
• W1968658549 hasConcept C2780069284 @default.
• W1968658549 hasConcept C2910325308 @default.
• W1968658549 hasConcept C45510557 @default.
• W1968658549 hasConcept C49773422 @default.
• W1968658549 hasConcept C55493867 @default.
• W1968658549 hasConcept C62478195 @default.
• W1968658549 hasConcept C71315377 @default.
• W1968658549 hasConcept C71924100 @default.
• W1968658549 hasConcept C75520062 @default.
• W1968658549 hasConcept C80631254 @default.
• W1968658549 hasConcept C86803240 @default.
• W1968658549 hasConcept C97029542 @default.
• W1968658549 hasConceptScore W1968658549C11960822 @default.
• W1968658549 hasConceptScore W1968658549C126322002 @default.
• W1968658549 hasConceptScore W1968658549C134018914 @default.
• W1968658549 hasConceptScore W1968658549C170493617 @default.
• W1968658549 hasConceptScore W1968658549C180526460 @default.
• W1968658549 hasConceptScore W1968658549C181199279 @default.
• W1968658549 hasConceptScore W1968658549C195794163 @default.
• W1968658549 hasConceptScore W1968658549C202751555 @default.
• W1968658549 hasConceptScore W1968658549C2776200302 @default.
• W1968658549 hasConceptScore W1968658549C2777006276 @default.
• W1968658549 hasConceptScore W1968658549C2778563252 @default.
• W1968658549 hasConceptScore W1968658549C2779276759 @default.
• W1968658549 hasConceptScore W1968658549C2780043322 @default.
• W1968658549 hasConceptScore W1968658549C2780069284 @default.
• W1968658549 hasConceptScore W1968658549C2910325308 @default.
• W1968658549 hasConceptScore W1968658549C45510557 @default.
• W1968658549 hasConceptScore W1968658549C49773422 @default.
• W1968658549 hasConceptScore W1968658549C55493867 @default.
• W1968658549 hasConceptScore W1968658549C62478195 @default.
• W1968658549 hasConceptScore W1968658549C71315377 @default.
• W1968658549 hasConceptScore W1968658549C71924100 @default.
• W1968658549 hasConceptScore W1968658549C75520062 @default.
• W1968658549 hasConceptScore W1968658549C80631254 @default.
• W1968658549 hasConceptScore W1968658549C86803240 @default.
• W1968658549 hasConceptScore W1968658549C97029542 @default.
• W1968658549 hasIssue "1" @default.
• W1968658549 hasLocation W19686585491 @default.

• next