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• W1968659828 abstract "Both mechanical loading and interleukin-1β (IL-1β) are known to regulate metabolic processes in articular cartilage through pathways mediated by nitric oxide (•NO) and PGE2. This study uses a well-characterized model system involving isolated chondrocytes cultured in agarose constructs to test the hypothesis that dynamic compression alters the synthesis of •NO and PGE2 by IL-1β-stimulated articular chondrocytes. The data presented demonstrate for the first time that dynamic compression counteracts the effects of IL-1β on articular chondrocytes by suppressing both •NO and PGE2 synthesis. Inhibitor experiments indicated that the dynamic compression-induced inhibition of PGE2 synthesis and stimulation of proteoglycan synthesis were •NO mediated, while compression-induced stimulation of cell proliferation was •NO independent. The inhibition of •NO and PGE2 by dynamic compression is a finding of major significance that could contribute to the development of novel strategies for the treatment of cartilage-degenerative disorders." @default.
• W1968659828 created "2016-06-24" @default.
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• W1968659828 date "2001-08-01" @default.
• W1968659828 modified "2023-10-09" @default.
• W1968659828 title "Dynamic Compression Inhibits the Synthesis of Nitric Oxide and PGE2 by IL-1β-Stimulated Chondrocytes Cultured in Agarose Constructs" @default.
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• W1968659828 doi "https://doi.org/10.1006/bbrc.2001.5311" @default.
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