FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968667062> ?p ?o ?g. }

• W1968667062 endingPage "279" @default.
• W1968667062 startingPage "270" @default.
• W1968667062 abstract "Fenretinide (HPR), a synthetic retinoid that exhibits lower toxicity than other retinoids, has shown preventive and therapeutic activity against ovarian tumors. Although the growth inhibitory effects of HPR have been ascribed to its ability to induce apoptosis, little is known about the molecular mechanisms involved. Since the proto-oncogene c-Fos has been implicated in apoptosis induction, we analyzed its role in mediating HPR response in a human ovarian carcinoma cell line (A2780) sensitive to HPR apoptotic effect. In these cells, HPR treatment caused induction of c-Fos expression, whereas such an effect was not observed in cells made resistant to HPR-induced apoptosis (A2780/HPR). Moreover, in a panel of other human ovarian carcinoma cell lines, c-Fos inducibility and HPR sensitivity were closely associated. Ceramide, which is involved in HPR-induced apoptosis, was also involved in c-Fos induction because its upregulation by HPR was reduced by fumonisin B(1), a ceramide synthase inhibitor. The causal relationship between c-Fos induction and apoptosis was established by the finding of an increased apoptotic rate in cells overexpressing c-Fos. Similarly to that observed for c-Fos expression, HPR treatment increased c-Jun expression in HPR-sensitive but not in HPR-resistant cells, suggesting the involvement of the transcription factor activating protein 1 (AP-1) in HPR-induced apoptosis. In gene reporter experiments, HPR stimulated AP-1 transcriptional activity and potentiated the AP-1 activity induced by 12-tetradecanoylphorbol 13-acetate. Furthermore, inhibition of AP-1 DNA binding, by transfecting A2780 cells with a dominant-negative Fos gene, caused decreased sensitivity to HPR apoptotic effects. Overall, the results indicate that c-Fos plays a role in mediating HPR-induced growth inhibition and apoptosis in ovarian cancer cells and suggest that c-Fos regulates these processes as a member of the AP-1 transcription factor." @default.
• W1968667062 created "2016-06-24" @default.
• W1968667062 creator A5013218430 @default.
• W1968667062 creator A5035474342 @default.
• W1968667062 creator A5060837793 @default.
• W1968667062 creator A5063003854 @default.
• W1968667062 creator A5069670729 @default.
• W1968667062 creator A5090431998 @default.
• W1968667062 date "2003-11-28" @default.
• W1968667062 modified "2023-10-07" @default.
• W1968667062 title "Involvement of c-Fos in fenretinide-induced apoptosis in human ovarian carcinoma cells" @default.
• W1968667062 cites W1551362684 @default.
• W1968667062 cites W1854025553 @default.
• W1968667062 cites W1857381743 @default.
• W1968667062 cites W1925078242 @default.
• W1968667062 cites W1964224609 @default.
• W1968667062 cites W1966315986 @default.
• W1968667062 cites W1972862393 @default.
• W1968667062 cites W1975542294 @default.
• W1968667062 cites W1976358642 @default.
• W1968667062 cites W1977955431 @default.
• W1968667062 cites W1984088932 @default.
• W1968667062 cites W1999463305 @default.
• W1968667062 cites W2001972438 @default.
• W1968667062 cites W2004023249 @default.
• W1968667062 cites W2005716792 @default.
• W1968667062 cites W2018232682 @default.
• W1968667062 cites W2025510871 @default.
• W1968667062 cites W2030486420 @default.
• W1968667062 cites W2040879971 @default.
• W1968667062 cites W2043298985 @default.
• W1968667062 cites W2058569877 @default.
• W1968667062 cites W2062465964 @default.
• W1968667062 cites W2066072183 @default.
• W1968667062 cites W2067427748 @default.
• W1968667062 cites W2074256825 @default.
• W1968667062 cites W2084223366 @default.
• W1968667062 cites W2098860085 @default.
• W1968667062 cites W2102420815 @default.
• W1968667062 cites W2105007462 @default.
• W1968667062 cites W2111030772 @default.
• W1968667062 cites W2123747845 @default.
• W1968667062 cites W2132076177 @default.
• W1968667062 cites W2132278175 @default.
• W1968667062 cites W2134428597 @default.
• W1968667062 cites W2141354259 @default.
• W1968667062 cites W2154015002 @default.
• W1968667062 cites W2155208683 @default.
• W1968667062 cites W2157239737 @default.
• W1968667062 cites W2167745866 @default.
• W1968667062 cites W2322523258 @default.
• W1968667062 cites W2409496467 @default.
• W1968667062 cites W2410958384 @default.
• W1968667062 cites W2418755088 @default.
• W1968667062 cites W2468222881 @default.
• W1968667062 doi "https://doi.org/10.1038/sj.cdd.4401349" @default.
• W1968667062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14647238" @default.
• W1968667062 hasPublicationYear "2003" @default.
• W1968667062 type Work @default.
• W1968667062 sameAs 1968667062 @default.
• W1968667062 citedByCount "29" @default.
• W1968667062 countsByYear W19686670622012 @default.
• W1968667062 countsByYear W19686670622013 @default.
• W1968667062 countsByYear W19686670622014 @default.
• W1968667062 countsByYear W19686670622015 @default.
• W1968667062 countsByYear W19686670622016 @default.
• W1968667062 countsByYear W19686670622017 @default.
• W1968667062 countsByYear W19686670622018 @default.
• W1968667062 countsByYear W19686670622020 @default.
• W1968667062 countsByYear W19686670622021 @default.
• W1968667062 countsByYear W19686670622022 @default.
• W1968667062 crossrefType "journal-article" @default.
• W1968667062 hasAuthorship W1968667062A5013218430 @default.
• W1968667062 hasAuthorship W1968667062A5035474342 @default.
• W1968667062 hasAuthorship W1968667062A5060837793 @default.
• W1968667062 hasAuthorship W1968667062A5063003854 @default.
• W1968667062 hasAuthorship W1968667062A5069670729 @default.
• W1968667062 hasAuthorship W1968667062A5090431998 @default.
• W1968667062 hasBestOaLocation W19686670621 @default.
• W1968667062 hasConcept C104317684 @default.
• W1968667062 hasConcept C127561419 @default.
• W1968667062 hasConcept C153911025 @default.
• W1968667062 hasConcept C185592680 @default.
• W1968667062 hasConcept C190283241 @default.
• W1968667062 hasConcept C2775954498 @default.
• W1968667062 hasConcept C2777851122 @default.
• W1968667062 hasConcept C2780533455 @default.
• W1968667062 hasConcept C2781121885 @default.
• W1968667062 hasConcept C502942594 @default.
• W1968667062 hasConcept C54355233 @default.
• W1968667062 hasConcept C55493867 @default.
• W1968667062 hasConcept C81885089 @default.
• W1968667062 hasConcept C86803240 @default.
• W1968667062 hasConceptScore W1968667062C104317684 @default.
• W1968667062 hasConceptScore W1968667062C127561419 @default.
• W1968667062 hasConceptScore W1968667062C153911025 @default.
• W1968667062 hasConceptScore W1968667062C185592680 @default.
• W1968667062 hasConceptScore W1968667062C190283241 @default.

• next