Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968672811> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1968672811 endingPage "339" @default.
- W1968672811 startingPage "339" @default.
- W1968672811 abstract "Leptin acts in the brain to suppress food intake and body adiposity, but in most cases obesity is associated with a resistance to leptin action. Protein tyrosine phosphatase 1B (PTP1B) dephosphorylates key components of the leptin receptor signaling cascade, and represents a molecular mediator of leptin resistance. Our recent work demonstrates that hypothalamic PTP1B levels are elevated in a model of aging-induced leptin resistance, and that acute inhibition of PTP1B improves hypothalamic leptin sensitivity in this setting. We therefore tested whether hypothalamic PTP1B is increased in diet-induced obesity, another model of leptin resistance. Twenty-eight days of high-fat (HF) feeding increased body weight and fat pad weights (P<0.05) compared to low-fat (LF), and also increased PTP1B protein levels in the mediobasal hypothalamus (P=0.003). To define a mechanism underlying this HF-induced increase in PTP1B, the independent effects of hyperleptinemia and exposure to a high-fat diet were tested. Leptin-deficient ob/ob mice were fed LF or HF diets and treated with leptin or saline for 14 days. Leptin treatment increased hypothalamic PTP1B in the LF mice (P=0.003), but had no effect in HF mice. However, HF mice exhibited a marked increase in hypothalamic PTP1B mRNA irrespective of leptin treatment (P<0.001). These data are consistent with the hypothesis that increases in hypothalamic PTP1B contribute to leptin resistance in response to a high-fat diet. While chronic increases in circulating leptin are sufficient to increase PTP1B, HF diets also directly stimulate hypothalamic PTP1B via a leptin-independent mechanism." @default.
- W1968672811 created "2016-06-24" @default.
- W1968672811 creator A5003182774 @default.
- W1968672811 creator A5020939481 @default.
- W1968672811 creator A5021897001 @default.
- W1968672811 creator A5047527237 @default.
- W1968672811 creator A5065268439 @default.
- W1968672811 creator A5080960032 @default.
- W1968672811 creator A5090973149 @default.
- W1968672811 date "2007-07-01" @default.
- W1968672811 modified "2023-10-04" @default.
- W1968672811 title "PTP1B: A molecular mediator of leptin resistance." @default.
- W1968672811 doi "https://doi.org/10.1016/j.appet.2007.03.214" @default.
- W1968672811 hasPublicationYear "2007" @default.
- W1968672811 type Work @default.
- W1968672811 sameAs 1968672811 @default.
- W1968672811 citedByCount "0" @default.
- W1968672811 crossrefType "journal-article" @default.
- W1968672811 hasAuthorship W1968672811A5003182774 @default.
- W1968672811 hasAuthorship W1968672811A5020939481 @default.
- W1968672811 hasAuthorship W1968672811A5021897001 @default.
- W1968672811 hasAuthorship W1968672811A5047527237 @default.
- W1968672811 hasAuthorship W1968672811A5065268439 @default.
- W1968672811 hasAuthorship W1968672811A5080960032 @default.
- W1968672811 hasAuthorship W1968672811A5090973149 @default.
- W1968672811 hasConcept C126322002 @default.
- W1968672811 hasConcept C134018914 @default.
- W1968672811 hasConcept C14372207 @default.
- W1968672811 hasConcept C2107291 @default.
- W1968672811 hasConcept C2777003273 @default.
- W1968672811 hasConcept C2777391703 @default.
- W1968672811 hasConcept C2780613262 @default.
- W1968672811 hasConcept C511355011 @default.
- W1968672811 hasConcept C71924100 @default.
- W1968672811 hasConcept C86803240 @default.
- W1968672811 hasConceptScore W1968672811C126322002 @default.
- W1968672811 hasConceptScore W1968672811C134018914 @default.
- W1968672811 hasConceptScore W1968672811C14372207 @default.
- W1968672811 hasConceptScore W1968672811C2107291 @default.
- W1968672811 hasConceptScore W1968672811C2777003273 @default.
- W1968672811 hasConceptScore W1968672811C2777391703 @default.
- W1968672811 hasConceptScore W1968672811C2780613262 @default.
- W1968672811 hasConceptScore W1968672811C511355011 @default.
- W1968672811 hasConceptScore W1968672811C71924100 @default.
- W1968672811 hasConceptScore W1968672811C86803240 @default.
- W1968672811 hasIssue "1" @default.
- W1968672811 hasLocation W19686728111 @default.
- W1968672811 hasOpenAccess W1968672811 @default.
- W1968672811 hasPrimaryLocation W19686728111 @default.
- W1968672811 hasRelatedWork W1976946227 @default.
- W1968672811 hasRelatedWork W2018026491 @default.
- W1968672811 hasRelatedWork W2022716990 @default.
- W1968672811 hasRelatedWork W2052679569 @default.
- W1968672811 hasRelatedWork W2074115578 @default.
- W1968672811 hasRelatedWork W2121606270 @default.
- W1968672811 hasRelatedWork W2159037117 @default.
- W1968672811 hasRelatedWork W2170321707 @default.
- W1968672811 hasRelatedWork W2398688629 @default.
- W1968672811 hasRelatedWork W2772070342 @default.
- W1968672811 hasVolume "49" @default.
- W1968672811 isParatext "false" @default.
- W1968672811 isRetracted "false" @default.
- W1968672811 magId "1968672811" @default.
- W1968672811 workType "article" @default.