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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968675059> ?p ?o ?g. }

• W1968675059 endingPage "116" @default.
• W1968675059 startingPage "109" @default.
• W1968675059 abstract "Previously it has been shown that the extracellular domain of transmembrane βA4 amyloid precursor protein (APP) includes binding sites for zine(II) and for molecules of the extracellular matrix such as collagen, laminin and the heparin sulfate chains of proteoglycans (HSPGs). Here we report that APP also binds copper ions. A copper type II binding site was located within residues 135–155 of the cysteine‐rich domain of APP 695 which is present in all eight APP splice isoforms known so far. The two essential histidines in the type II copper binding site of APP are conserved in the related protein APLP 2 . Copper(II) binding is shown to inhibit homophilic APP binding. The identification of a copper(II) binding site in APP suggests that APP and APLP 2 may be involved in electron transfer and radical reactions." @default.
• W1968675059 created "2016-06-24" @default.
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• W1968675059 date "1994-07-25" @default.
• W1968675059 modified "2023-10-03" @default.
• W1968675059 title "The βA4 amyloid precursor protein binding to copper" @default.
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• W1968675059 doi "https://doi.org/10.1016/0014-5793(94)00658-x" @default.
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