FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968675501> ?p ?o ?g. }

• W1968675501 abstract "The objective of the present study is to investigate the effect of hydrocarbon chain length in 1,2-alkanediols on percutaneous absorption of metronidazole (MTZ). Twelve formulations (1,2-propanediol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol in 4% concentration, 1,2-hexanediol, and 1,2-heptanediol in 1% concentration, in the absence and presence of 1,4-cyclohexanediol, respectively) were studied in an in vitro hairless mouse skin model using Franz diffusion cell. Based on the flux values and retardation ratios (RR), a penetration retardation effect on percutaneous absorption of MTZ was observed for the formulations containing 1,2-diols having six- to seven-carbon chain in the presence of 1,4-cyclohexanediol (1,2-hexanediol with chain length of six hydrocarbons, RRs are 0.69 and 0.76 in the concentration of 4% and 1%, respectively; 1,2-heptanediol with chain length of seven hydrocarbons, RR is 0.78 in the concentration of 1%). On the other hand, no retardation effect was observed in formulations containing short alkyl chains (RRs of 1,2-propanediol, 1,2-butanediol, and 1,2-pentanediol are 0.99, 1.61, and 0.96, respectively). Instead, a penetration enhancement effect was observed for 1,2-diols having four and five carbons. In other words, effect of 1,2-alkanediols on percutaneous absorption of MTZ can be systematically modulated by simply varying number of -CH2 groups in the hydrocarbon chain-from being a penetration enhancer to retardant. These observations shed light on mechanism of the penetration enhancement and retardation effect and provide insight into rational design of penetration enhancers and retardants. Furthermore, the combination of 1,2-alkanediols and 1,4-cyclohexanediol could become a general vehicle for controlled release of pharmaceutical and cosmetic active ingredients." @default.
• W1968675501 created "2016-06-24" @default.
• W1968675501 creator A5012500851 @default.
• W1968675501 creator A5015105154 @default.
• W1968675501 creator A5037621877 @default.
• W1968675501 creator A5086664284 @default.
• W1968675501 creator A5090247844 @default.
• W1968675501 creator A5049295664 @default.
• W1968675501 date "2014-01-07" @default.
• W1968675501 modified "2023-10-06" @default.
• W1968675501 title "Effect of Hydrocarbon Chain Length in 1,2-Alkanediols on Percutaneous Absorption of Metronidazole: Toward Development of a General Vehicle for Controlled Release" @default.
• W1968675501 cites W1544311753 @default.
• W1968675501 cites W1966913918 @default.
• W1968675501 cites W1976223942 @default.
• W1968675501 cites W2008505583 @default.
• W1968675501 cites W2010507065 @default.
• W1968675501 cites W2012391445 @default.
• W1968675501 cites W2015266188 @default.
• W1968675501 cites W2020990282 @default.
• W1968675501 cites W2021093101 @default.
• W1968675501 cites W2025907088 @default.
• W1968675501 cites W2028172840 @default.
• W1968675501 cites W2030749147 @default.
• W1968675501 cites W2036424067 @default.
• W1968675501 cites W2059261587 @default.
• W1968675501 cites W2080941028 @default.
• W1968675501 cites W2141552836 @default.
• W1968675501 cites W2476789114 @default.
• W1968675501 cites W396925355 @default.
• W1968675501 cites W2521375135 @default.
• W1968675501 doi "https://doi.org/10.1208/s12249-013-0066-7" @default.
• W1968675501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3969481" @default.
• W1968675501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24395400" @default.
• W1968675501 hasPublicationYear "2014" @default.
• W1968675501 type Work @default.
• W1968675501 sameAs 1968675501 @default.
• W1968675501 citedByCount "3" @default.
• W1968675501 countsByYear W19686755012014 @default.
• W1968675501 countsByYear W19686755012015 @default.
• W1968675501 countsByYear W19686755012020 @default.
• W1968675501 crossrefType "journal-article" @default.
• W1968675501 hasAuthorship W1968675501A5012500851 @default.
• W1968675501 hasAuthorship W1968675501A5015105154 @default.
• W1968675501 hasAuthorship W1968675501A5037621877 @default.
• W1968675501 hasAuthorship W1968675501A5049295664 @default.
• W1968675501 hasAuthorship W1968675501A5086664284 @default.
• W1968675501 hasAuthorship W1968675501A5090247844 @default.
• W1968675501 hasBestOaLocation W19686755012 @default.
• W1968675501 hasConcept C125287762 @default.
• W1968675501 hasConcept C126348684 @default.
• W1968675501 hasConcept C127413603 @default.
• W1968675501 hasConcept C155574463 @default.
• W1968675501 hasConcept C159985019 @default.
• W1968675501 hasConcept C178790620 @default.
• W1968675501 hasConcept C185592680 @default.
• W1968675501 hasConcept C192562407 @default.
• W1968675501 hasConcept C2777207669 @default.
• W1968675501 hasConcept C2779515768 @default.
• W1968675501 hasConcept C2780263894 @default.
• W1968675501 hasConcept C2780471494 @default.
• W1968675501 hasConcept C3020382795 @default.
• W1968675501 hasConcept C42475967 @default.
• W1968675501 hasConcept C80107235 @default.
• W1968675501 hasConceptScore W1968675501C125287762 @default.
• W1968675501 hasConceptScore W1968675501C126348684 @default.
• W1968675501 hasConceptScore W1968675501C127413603 @default.
• W1968675501 hasConceptScore W1968675501C155574463 @default.
• W1968675501 hasConceptScore W1968675501C159985019 @default.
• W1968675501 hasConceptScore W1968675501C178790620 @default.
• W1968675501 hasConceptScore W1968675501C185592680 @default.
• W1968675501 hasConceptScore W1968675501C192562407 @default.
• W1968675501 hasConceptScore W1968675501C2777207669 @default.
• W1968675501 hasConceptScore W1968675501C2779515768 @default.
• W1968675501 hasConceptScore W1968675501C2780263894 @default.
• W1968675501 hasConceptScore W1968675501C2780471494 @default.
• W1968675501 hasConceptScore W1968675501C3020382795 @default.
• W1968675501 hasConceptScore W1968675501C42475967 @default.
• W1968675501 hasConceptScore W1968675501C80107235 @default.
• W1968675501 hasLocation W19686755011 @default.
• W1968675501 hasLocation W19686755012 @default.
• W1968675501 hasLocation W19686755013 @default.
• W1968675501 hasLocation W19686755014 @default.
• W1968675501 hasOpenAccess W1968675501 @default.
• W1968675501 hasPrimaryLocation W19686755011 @default.
• W1968675501 hasRelatedWork W154727371 @default.
• W1968675501 hasRelatedWork W1966117429 @default.
• W1968675501 hasRelatedWork W1986444327 @default.
• W1968675501 hasRelatedWork W1993589491 @default.
• W1968675501 hasRelatedWork W1999806354 @default.
• W1968675501 hasRelatedWork W2012391445 @default.
• W1968675501 hasRelatedWork W2022029266 @default.
• W1968675501 hasRelatedWork W2022761744 @default.
• W1968675501 hasRelatedWork W2039761798 @default.
• W1968675501 hasRelatedWork W2042912042 @default.
• W1968675501 hasRelatedWork W2059187744 @default.
• W1968675501 hasRelatedWork W2059261587 @default.
• W1968675501 hasRelatedWork W2125395981 @default.
• W1968675501 hasRelatedWork W2170730991 @default.
• W1968675501 hasRelatedWork W2314709336 @default.
• W1968675501 hasRelatedWork W2326381147 @default.

• next