Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968684705> ?p ?o ?g. }
- W1968684705 endingPage "147" @default.
- W1968684705 startingPage "135" @default.
- W1968684705 abstract "In vitro receptor binding techniques were used to identify the cellular location of nicotinic and muscarinic cholinergic and μ-opiate receptors in the fronto-parietal region of rat cerebral neocortex. Changes in the normal pattern of receptor binding of ligands for these 3 receptors were examined in a series of adjacent sections after unilateral thalamic fiber or cortical cell lesions. Thalamocortical fibers were destroyed by making either electrolytic lesions or kainic acid injections centered in the region of the thalamic ventrobasal complex. These lesions reduced cortical labeling of nicotinic ([3H]nicotine) and μ-opiate ([3H]DAGO) receptors while they did not affect cortical muscarinic ([3H]quinuclidinyl benzilate ([3H]QNB)) labeling. Intracortical injections of quinolinic acid (QA) were used to destroy cortical neurons and spare extrinsic fibers. Cortical QA lesions markedly reduced muscarinic and μ-opiate labeling, but had no significant effect on nicotinic binding at short survivals. Our results suggest that a subset of nicotinic receptors is located presynaptically on the specific thalamo-cortical fibers, while muscarinic receptors are located primarily on cortical neurons. Receptors of the μ-opiate type appear to be located both presynaptically on thalamo-cortical terminals and on intrinsic cortical neurons. The differences in the location of these receptor types suggest that each one modulates discrete aspects of cortical processing." @default.
- W1968684705 created "2016-06-24" @default.
- W1968684705 creator A5029666654 @default.
- W1968684705 creator A5036190821 @default.
- W1968684705 creator A5079691093 @default.
- W1968684705 date "1992-05-01" @default.
- W1968684705 modified "2023-10-17" @default.
- W1968684705 title "Location of nicotinic and muscarinic cholinergic and μ-opiate receptors in rat cerebral neocortex: evidence from thalamic and cortical lesions" @default.
- W1968684705 cites W1543598925 @default.
- W1968684705 cites W1608212407 @default.
- W1968684705 cites W1637093671 @default.
- W1968684705 cites W1637481752 @default.
- W1968684705 cites W1866773095 @default.
- W1968684705 cites W1972717147 @default.
- W1968684705 cites W1979686107 @default.
- W1968684705 cites W1981922585 @default.
- W1968684705 cites W1983446192 @default.
- W1968684705 cites W1984064067 @default.
- W1968684705 cites W1985231430 @default.
- W1968684705 cites W1985272934 @default.
- W1968684705 cites W1987401576 @default.
- W1968684705 cites W1987964421 @default.
- W1968684705 cites W1990989480 @default.
- W1968684705 cites W1999429531 @default.
- W1968684705 cites W2000238219 @default.
- W1968684705 cites W2000643162 @default.
- W1968684705 cites W2010277278 @default.
- W1968684705 cites W2014630817 @default.
- W1968684705 cites W2016577623 @default.
- W1968684705 cites W2020244809 @default.
- W1968684705 cites W2022567711 @default.
- W1968684705 cites W2025155885 @default.
- W1968684705 cites W2025465807 @default.
- W1968684705 cites W2028494401 @default.
- W1968684705 cites W2029569264 @default.
- W1968684705 cites W2032314347 @default.
- W1968684705 cites W2033884811 @default.
- W1968684705 cites W2035261062 @default.
- W1968684705 cites W2036489186 @default.
- W1968684705 cites W2038299024 @default.
- W1968684705 cites W2038328684 @default.
- W1968684705 cites W2038995429 @default.
- W1968684705 cites W2040361910 @default.
- W1968684705 cites W2043623104 @default.
- W1968684705 cites W2051353156 @default.
- W1968684705 cites W2060516434 @default.
- W1968684705 cites W2060551035 @default.
- W1968684705 cites W2065009632 @default.
- W1968684705 cites W2071928455 @default.
- W1968684705 cites W2073613999 @default.
- W1968684705 cites W2080781505 @default.
- W1968684705 cites W2081910239 @default.
- W1968684705 cites W2083447586 @default.
- W1968684705 cites W2084374224 @default.
- W1968684705 cites W2084604636 @default.
- W1968684705 cites W2084968056 @default.
- W1968684705 cites W2085711348 @default.
- W1968684705 cites W2087751310 @default.
- W1968684705 cites W2121570462 @default.
- W1968684705 cites W2148006968 @default.
- W1968684705 cites W2162545338 @default.
- W1968684705 cites W2168578761 @default.
- W1968684705 cites W2338041628 @default.
- W1968684705 doi "https://doi.org/10.1016/0006-8993(92)90752-u" @default.
- W1968684705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1320443" @default.
- W1968684705 hasPublicationYear "1992" @default.
- W1968684705 type Work @default.
- W1968684705 sameAs 1968684705 @default.
- W1968684705 citedByCount "64" @default.
- W1968684705 countsByYear W19686847052012 @default.
- W1968684705 countsByYear W19686847052015 @default.
- W1968684705 countsByYear W19686847052016 @default.
- W1968684705 countsByYear W19686847052017 @default.
- W1968684705 countsByYear W19686847052018 @default.
- W1968684705 countsByYear W19686847052020 @default.
- W1968684705 countsByYear W19686847052022 @default.
- W1968684705 crossrefType "journal-article" @default.
- W1968684705 hasAuthorship W1968684705A5029666654 @default.
- W1968684705 hasAuthorship W1968684705A5036190821 @default.
- W1968684705 hasAuthorship W1968684705A5079691093 @default.
- W1968684705 hasConcept C134018914 @default.
- W1968684705 hasConcept C169760540 @default.
- W1968684705 hasConcept C170493617 @default.
- W1968684705 hasConcept C185592680 @default.
- W1968684705 hasConcept C188987157 @default.
- W1968684705 hasConcept C22885893 @default.
- W1968684705 hasConcept C2776108384 @default.
- W1968684705 hasConcept C2777222312 @default.
- W1968684705 hasConcept C2781041448 @default.
- W1968684705 hasConcept C33789571 @default.
- W1968684705 hasConcept C47488739 @default.
- W1968684705 hasConcept C55493867 @default.
- W1968684705 hasConcept C61174792 @default.
- W1968684705 hasConcept C64123433 @default.
- W1968684705 hasConcept C86803240 @default.
- W1968684705 hasConceptScore W1968684705C134018914 @default.
- W1968684705 hasConceptScore W1968684705C169760540 @default.
- W1968684705 hasConceptScore W1968684705C170493617 @default.