Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968690802> ?p ?o ?g. }
- W1968690802 endingPage "88" @default.
- W1968690802 startingPage "81" @default.
- W1968690802 abstract "Abstract Chronic relapsing experimental autoimmune encephalomyelitis (ChREAE) is an autoimmune disease of the central nervous system (CNS) induced by CNS myelin components. In the early active stage, both ChREAE and multiple sclerosis (MS) are characterized by the presence of perivascular inflammatory cuffs disseminated in the CNS. There is growing evidence that chemoattractant cytokines (chemokines) play an important role in this process. The main goal of the present study was to analyse the hypothesis that chemokine expression in the CNS during autoimmune inflammation is regulated by proinflammatory cytokines. To address this concept, we analysed temporal relations between chemokine and cytokine expression during ChREAE. Phasic upregulation of gene expression for chemokines T‐cell activation gene 3 (TCA‐3)/CCL1, monocyte chemoattractant protein‐1 (MCP‐1)/CCL2, macrophage inflammatory protein‐1 alpha (MIP‐1α)/CCL3, MIP‐1β/CCL4, regulated on activation normal T cell expressed and secreted (RANTES)/CCL5 and MIP‐2/CXCL2–3 as well as cytokines tumour necrosis factor‐α (TNF‐α), ‐β, LT‐β, interferon‐γ (IFN‐γ) and transforming growth factor‐β1 (TGF‐β1) in the CNS was observed during attacks of ChREAE. Expression of cytokines TNF‐β and LT‐β preceded, and the expression of TGF‐β1 followed chemokine upregulation. Our results suggest that chemokine expression during CNS autoimmune inflammation may be regulated by some proinflammatory cytokines." @default.
- W1968690802 created "2016-06-24" @default.
- W1968690802 creator A5021051869 @default.
- W1968690802 creator A5069514427 @default.
- W1968690802 creator A5073386134 @default.
- W1968690802 date "2003-06-26" @default.
- W1968690802 modified "2023-10-15" @default.
- W1968690802 title "Chemokine Upregulation Follows Cytokine Expression in Chronic Relapsing Experimental Autoimmune Encephalomyelitis" @default.
- W1968690802 cites W1558962636 @default.
- W1968690802 cites W1560656231 @default.
- W1968690802 cites W1633680516 @default.
- W1968690802 cites W1652237838 @default.
- W1968690802 cites W1946924519 @default.
- W1968690802 cites W1955666311 @default.
- W1968690802 cites W1973445893 @default.
- W1968690802 cites W1977768701 @default.
- W1968690802 cites W1996710864 @default.
- W1968690802 cites W2004694654 @default.
- W1968690802 cites W2005659566 @default.
- W1968690802 cites W2012656284 @default.
- W1968690802 cites W2014944455 @default.
- W1968690802 cites W2019577957 @default.
- W1968690802 cites W2019976074 @default.
- W1968690802 cites W2021239306 @default.
- W1968690802 cites W2026063970 @default.
- W1968690802 cites W2027148872 @default.
- W1968690802 cites W2029664013 @default.
- W1968690802 cites W2036609995 @default.
- W1968690802 cites W2044907860 @default.
- W1968690802 cites W2057379124 @default.
- W1968690802 cites W2058034375 @default.
- W1968690802 cites W2076923050 @default.
- W1968690802 cites W2113051156 @default.
- W1968690802 cites W2113501117 @default.
- W1968690802 cites W2113509623 @default.
- W1968690802 cites W2122946630 @default.
- W1968690802 cites W2160272188 @default.
- W1968690802 cites W2170409475 @default.
- W1968690802 cites W4313333659 @default.
- W1968690802 cites W4313342412 @default.
- W1968690802 doi "https://doi.org/10.1046/j.1365-3083.2003.01285.x" @default.
- W1968690802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12828562" @default.
- W1968690802 hasPublicationYear "2003" @default.
- W1968690802 type Work @default.
- W1968690802 sameAs 1968690802 @default.
- W1968690802 citedByCount "44" @default.
- W1968690802 countsByYear W19686908022012 @default.
- W1968690802 countsByYear W19686908022013 @default.
- W1968690802 countsByYear W19686908022014 @default.
- W1968690802 countsByYear W19686908022015 @default.
- W1968690802 countsByYear W19686908022017 @default.
- W1968690802 countsByYear W19686908022019 @default.
- W1968690802 countsByYear W19686908022021 @default.
- W1968690802 countsByYear W19686908022022 @default.
- W1968690802 crossrefType "journal-article" @default.
- W1968690802 hasAuthorship W1968690802A5021051869 @default.
- W1968690802 hasAuthorship W1968690802A5069514427 @default.
- W1968690802 hasAuthorship W1968690802A5073386134 @default.
- W1968690802 hasBestOaLocation W19686908021 @default.
- W1968690802 hasConcept C101666144 @default.
- W1968690802 hasConcept C110015553 @default.
- W1968690802 hasConcept C116484652 @default.
- W1968690802 hasConcept C12823836 @default.
- W1968690802 hasConcept C13373296 @default.
- W1968690802 hasConcept C164027704 @default.
- W1968690802 hasConcept C170217031 @default.
- W1968690802 hasConcept C179661763 @default.
- W1968690802 hasConcept C17991360 @default.
- W1968690802 hasConcept C203014093 @default.
- W1968690802 hasConcept C2776090121 @default.
- W1968690802 hasConcept C2776914184 @default.
- W1968690802 hasConcept C2778486448 @default.
- W1968690802 hasConcept C2778690821 @default.
- W1968690802 hasConcept C2779357208 @default.
- W1968690802 hasConcept C29146819 @default.
- W1968690802 hasConcept C5858377 @default.
- W1968690802 hasConcept C79484868 @default.
- W1968690802 hasConcept C86803240 @default.
- W1968690802 hasConcept C8891405 @default.
- W1968690802 hasConceptScore W1968690802C101666144 @default.
- W1968690802 hasConceptScore W1968690802C110015553 @default.
- W1968690802 hasConceptScore W1968690802C116484652 @default.
- W1968690802 hasConceptScore W1968690802C12823836 @default.
- W1968690802 hasConceptScore W1968690802C13373296 @default.
- W1968690802 hasConceptScore W1968690802C164027704 @default.
- W1968690802 hasConceptScore W1968690802C170217031 @default.
- W1968690802 hasConceptScore W1968690802C179661763 @default.
- W1968690802 hasConceptScore W1968690802C17991360 @default.
- W1968690802 hasConceptScore W1968690802C203014093 @default.
- W1968690802 hasConceptScore W1968690802C2776090121 @default.
- W1968690802 hasConceptScore W1968690802C2776914184 @default.
- W1968690802 hasConceptScore W1968690802C2778486448 @default.
- W1968690802 hasConceptScore W1968690802C2778690821 @default.
- W1968690802 hasConceptScore W1968690802C2779357208 @default.
- W1968690802 hasConceptScore W1968690802C29146819 @default.
- W1968690802 hasConceptScore W1968690802C5858377 @default.
- W1968690802 hasConceptScore W1968690802C79484868 @default.
- W1968690802 hasConceptScore W1968690802C86803240 @default.