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• W1968692366 abstract "Summary Background Second‐generation antihistamines are H 1 receptor antagonists and may have additional anti‐inflammatory effects. Objective The aims of the study were to evaluate the effect of desloratadine (DL) on cytokine secretion by epithelial cells from both nasal mucosa (NM) and polyps (NP), and on eosinophil survival primed by epithelial cell secretions. Methods Epithelial cells were cultured and stimulated with fetal bovine serum (FBS), IL‐1β or TNF‐α with and without DL for 24 h. Culture supernatant cytokines concentration were measured by ELISA. Peripheral blood eosinophils were incubated with human epithelial cell conditioned media (HECM) and DL. Eosinophil survival was assessed by Trypan blue dye exclusion. Results are expressed as mean±SEM of cytokine concentration (pg/mL) or eosinophil survival index (%). Results FBS increased granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), vascular endothelial growth factor (VEGF), IL‐6, IL‐8, and TGF‐β 1 secretion in epithelial cell cultures from both NM and NP. Only GM‐CSF secretion was significantly ( P <0.05) inhibited by a dose‐response of DL compared with positive controls, in both NM (10 −5 m : 125±36 pg/mL, 10 −6 m : 95±22 pg/mL vs. control: 256±91 pg/mL, n =6) and NP (10 −5 m : 80±29 pg/mL, 10 −6 m : 109±45 pg/mL vs. control: 333±212 pg/mL, n =6). DL also showed an inhibitory effect on HECM‐induced eosinophil survival from both NM and NP. At 72 h, DL significantly ( P <0.01) inhibited eosinophil survival induced by HECM from NM (10 −5 m : 19.9±5.5%, n =9; 10 −6 m : 28.7±7.7%, n =9) and NP (10 −5 m : 6.2±2.8%, n =11) compared with HECM alone (NM: 42.1±7.3%; NP: 45.3±8.1%). Conclusion The inhibitory effects of DL on epithelial cell GM‐CSF secretion and on eosinophil survival induced by epithelial cell secretions, suggest that this H 1 antagonist may regulate eosinophil inflammation in upper airways." @default.
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• W1968692366 date "2005-12-22" @default.
• W1968692366 modified "2023-10-15" @default.
• W1968692366 title "Effect of desloratadine on epithelial cell granulocyte-macrophage colony-stimulating factor secretion and eosinophil survival" @default.
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• W1968692366 doi "https://doi.org/10.1111/j.1365-2222.2005.02403.x" @default.
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