FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968732005> ?p ?o ?g. }

• W1968732005 abstract "Background Multiple Sclerosis (MS) is a chronic, recurrent and progressive illness with no cure. On the basis of speculative pathophysiology, it has been suggested that Hyperbaric Oxygen Therapy (HBOT) may slow or reverse the progress of the disease. Objectives The object of this review was to evaluate the efficacy and safety of HBOT in the treatment of MS. Search methods We searched the Cochrane Multiple Sclerosis Group's Trials Register (25 February 2011). Selection criteria All randomised, controlled trials involving a comparison between HBOT and a sham therapy in MS were evaluated. Data collection and analysis Two reviewers independently appraised all comparative trials identified, extracted data and scored them for methodological quality. Main results We identified ten reports of nine trials that satisfied selection criteria (504 participants in total). Two trials produced generally positive results, while the remaining seven reported generally no evidence of a treatment effect. None of our three a priori subgroup analyses placed these two trials in the same group and were therefore unable to account for this difference. Three analyses (of 21) did indicate some benefit. For example, the mean Expanded Disability Status Scale (EDSS) at 12 months was improved in the HBOT group (group mean reduction in EDSS compared to sham ‐0.85 of a point, 95% confidence interval ‐1.28 to ‐0.42, P = 0.0001). Only the two generally positive trials reported on this outcome at this time (16% of the total participants in this review). Authors' conclusions We found no consistent evidence to confirm a beneficial effect of hyperbaric oxygen therapy for the treatment of multiple sclerosis and do not believe routine use is justified. The small number of analyses suggestive of benefit are isolated, difficult to ascribe with biological plausibility and would need to be confirmed in future well‐designed trials. Such trials are not, in our view, justified by this review." @default.
• W1968732005 created "2016-06-24" @default.
• W1968732005 creator A5009846711 @default.
• W1968732005 creator A5069908761 @default.
• W1968732005 date "2004-01-26" @default.
• W1968732005 modified "2023-09-27" @default.
• W1968732005 title "Hyperbaric oxygen therapy for multiple sclerosis" @default.
• W1968732005 cites W1485262693 @default.
• W1968732005 cites W1964117749 @default.
• W1968732005 cites W1966089363 @default.
• W1968732005 cites W1968044134 @default.
• W1968732005 cites W1979215300 @default.
• W1968732005 cites W1986215651 @default.
• W1968732005 cites W2021012212 @default.
• W1968732005 cites W2022273098 @default.
• W1968732005 cites W2033485016 @default.
• W1968732005 cites W2037483779 @default.
• W1968732005 cites W2056988959 @default.
• W1968732005 cites W2058543715 @default.
• W1968732005 cites W2064687595 @default.
• W1968732005 cites W2093471482 @default.
• W1968732005 cites W2112165124 @default.
• W1968732005 cites W2130355701 @default.
• W1968732005 cites W2147782392 @default.
• W1968732005 cites W2147784004 @default.
• W1968732005 cites W2149196419 @default.
• W1968732005 cites W2324654103 @default.
• W1968732005 cites W2328945749 @default.
• W1968732005 cites W2345650156 @default.
• W1968732005 cites W2461818433 @default.
• W1968732005 doi "https://doi.org/10.1002/14651858.cd003057.pub2" @default.
• W1968732005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8407327" @default.
• W1968732005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14974004" @default.
• W1968732005 hasPublicationYear "2004" @default.
• W1968732005 type Work @default.
• W1968732005 sameAs 1968732005 @default.
• W1968732005 citedByCount "30" @default.
• W1968732005 countsByYear W19687320052012 @default.
• W1968732005 countsByYear W19687320052015 @default.
• W1968732005 countsByYear W19687320052016 @default.
• W1968732005 countsByYear W19687320052017 @default.
• W1968732005 countsByYear W19687320052018 @default.
• W1968732005 countsByYear W19687320052019 @default.
• W1968732005 countsByYear W19687320052021 @default.
• W1968732005 countsByYear W19687320052022 @default.
• W1968732005 countsByYear W19687320052023 @default.
• W1968732005 crossrefType "journal-article" @default.
• W1968732005 hasAuthorship W1968732005A5009846711 @default.
• W1968732005 hasAuthorship W1968732005A5069908761 @default.
• W1968732005 hasBestOaLocation W19687320052 @default.
• W1968732005 hasConcept C118552586 @default.
• W1968732005 hasConcept C126322002 @default.
• W1968732005 hasConcept C141071460 @default.
• W1968732005 hasConcept C168563851 @default.
• W1968732005 hasConcept C1862650 @default.
• W1968732005 hasConcept C2780640218 @default.
• W1968732005 hasConcept C2780892749 @default.
• W1968732005 hasConcept C2994405533 @default.
• W1968732005 hasConcept C44249647 @default.
• W1968732005 hasConcept C535046627 @default.
• W1968732005 hasConcept C71924100 @default.
• W1968732005 hasConceptScore W1968732005C118552586 @default.
• W1968732005 hasConceptScore W1968732005C126322002 @default.
• W1968732005 hasConceptScore W1968732005C141071460 @default.
• W1968732005 hasConceptScore W1968732005C168563851 @default.
• W1968732005 hasConceptScore W1968732005C1862650 @default.
• W1968732005 hasConceptScore W1968732005C2780640218 @default.
• W1968732005 hasConceptScore W1968732005C2780892749 @default.
• W1968732005 hasConceptScore W1968732005C2994405533 @default.
• W1968732005 hasConceptScore W1968732005C44249647 @default.
• W1968732005 hasConceptScore W1968732005C535046627 @default.
• W1968732005 hasConceptScore W1968732005C71924100 @default.
• W1968732005 hasIssue "8" @default.
• W1968732005 hasLocation W19687320051 @default.
• W1968732005 hasLocation W19687320052 @default.
• W1968732005 hasOpenAccess W1968732005 @default.
• W1968732005 hasPrimaryLocation W19687320051 @default.
• W1968732005 hasRelatedWork W1986008120 @default.
• W1968732005 hasRelatedWork W2033485016 @default.
• W1968732005 hasRelatedWork W2070961742 @default.
• W1968732005 hasRelatedWork W2107516864 @default.
• W1968732005 hasRelatedWork W2108647028 @default.
• W1968732005 hasRelatedWork W2113848764 @default.
• W1968732005 hasRelatedWork W2253320584 @default.
• W1968732005 hasRelatedWork W2342194644 @default.
• W1968732005 hasRelatedWork W2808801810 @default.
• W1968732005 hasRelatedWork W4280533241 @default.
• W1968732005 hasVolume "2011" @default.
• W1968732005 isParatext "false" @default.
• W1968732005 isRetracted "false" @default.
• W1968732005 magId "1968732005" @default.
• W1968732005 workType "article" @default.