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- W1968739222 abstract "A strong link between brain vascularity and Alzheimer's disease (AD) exits due to evidence of reduced blood-brain barrier (BBB) integrity preceding other AD neuropatholgies. Current dogma holds that BBB leakiness in AD is likely due to vascular deterioration and apoptosis. We propose an alternative hypothesis: angiogenesis and hypervascularization underlie increased vascular permeability in AD. Cerebrovascular integrity was characterized in Tg2576 AD model mice by examining the expression of tight junction (TJ) proteins (occludin and ZO-1) in conjunction with markers of apoptosis and angiogenesis. In aged AD mice, a significant increase in the incidence of disrupted TJs was directly linked to an increased microvascular density but not apoptosis, which strongly supports hypervascularity as a basis for BBB dysfunction. Our results demonstrate that AD related BBB disruption is due to neoangiogenesis, resulting in the redistribution of TJs that maintain the barrier thus providing a new paradigm for connecting vascular remodelling with AD." @default.
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- W1968739222 date "2011-07-01" @default.
- W1968739222 modified "2023-09-27" @default.
- W1968739222 title "P4-314: Reduced cerebrovascular tight junction integrity in Alzheimer's disease is directly linked to hypervascularity and angiogenesis" @default.
- W1968739222 doi "https://doi.org/10.1016/j.jalz.2011.09.059" @default.
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