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• W1968740548 abstract "Background— Matrix metalloproteinases (MMP) are implicated in cardiovascular disease. Growth hormone (GH) deficiency is associated with increased cardiovascular mortality. We assessed whether GH replacement, in GH-deficient adults, has any effect on plasma levels of MMP-2 and MMP-9 and on vascular endothelial growth factor (VEGF), known to activate MMPs. Methods and Results— The study comprised 66 GH-deficient adults, 37.8±14.7 years of age (37 female). Plasma MMP-2 and MMP-9, VEGF, and insulin-like growth factor-1 (IGF-1) were measured at baseline (V 1 ), at 12 months (V 2 ), and at 24 months of GH treatment (V 3 ). IGF-1 levels rose under GH replacement (mean±SD): V 1 , 151.6±91.9 μg/mL; V 2 , 270.2±114.8 μg/mL; and V 3 , 266.2±109.8 (V 1 versus V 2 ; P <0.001: V 2 versus V 3 ; P =0.76). MMP-9 exhibited the most pronounced and sustained decline from 1248.0±651.1 ng/mL at V 1 , 949.2±457.7 ng/mL at V 2 , and 760.8±386.1 ng/mL at V 3 ( P <0.001 at all time points). A similar pattern was detected for VEGF levels: 358.5±209.0 pg/mL at V 1 , 310.6±225.7 pg/mL at V 2 ( P <0.001), and 283.7±202.7 pg/mL at V 3 (V 2 versus V 3 ; P =0.005). MMP-2 demonstrated a significant decline initially from V 1 to V 2 (1134.4±217.8 ng/mL versus 1074.5±203.0 ng/mL, respectively; P =0.031), reaching a plateau at V 3 (1072.3±220.2 ng/mL) (V 2 versus V 3 ; P =0.93). A negative relation existed between MMP-9 versus IGF-1 and MMP-2 versus IGF-1 ( P <0.001 and P =0.007, respectively) as well as between VEGF and IGF-1 ( P <0.001). Conclusions— These changes in MMPs and VEGF may contribute to the anticipated reduction in vascular mortality in hypopituitary adults receiving GH replacement." @default.
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• W1968740548 date "2004-05-25" @default.
• W1968740548 modified "2023-10-14" @default.
• W1968740548 title "Growth Hormone Replacement Decreases Plasma Levels of Matrix Metalloproteinases (2 and 9) and Vascular Endothelial Growth Factor in Growth Hormone–Deficient Individuals" @default.
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• W1968740548 doi "https://doi.org/10.1161/01.cir.0000129763.51060.77" @default.
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