FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968744498> ?p ?o ?g. }

• W1968744498 endingPage "1108" @default.
• W1968744498 startingPage "1101" @default.
• W1968744498 abstract "Background Oxidative stress and inflammation have been proposed as emerging components of metabolic syndrome (MetS). Curcuminoids are natural polyphenols with strong antioxidant and anti-inflammatory properties. Objective To study the effectiveness of supplementation with a bioavailable curcuminoid preparation on measures of oxidative stress and inflammation in patients with MetS. Our secondary aim was to perform a meta-analysis of data from all randomized controlled trials in order to estimate the effect size of curcuminoids on plasma C-reactive protein (CRP) concentrations. Methods In this randomized double-blind placebo-controlled trial, 117 subjects with MetS (according to the NCEP-ATPIII diagnostic criteria) were randomly assigned to curcuminoids (n = 59; drop-outs = 9) or placebo (n = 58; drop-outs = 8) for eight weeks. Curcuminoids were administered at a daily dose of 1 g, and were co-supplemented with piperine (10 mg/day) in order to boost oral bioavailability. Serum activities of superoxide dismutase (SOD) and concentrations of malondialdehyde (MDA) and CRP were measured at baseline and at study end. Regarding the importance of CRP as a risk marker and risk factor of cardiovascular disease, a random-effects meta-analysis of clinical trials was performed to estimate the overall impact of curcuminoid therapy on circulating concentrations of CRP. The robustness of estimated effect size was evaluated using leave-one-out sensitivity analysis. Results Supplementation with curcuminoid-piperine combination significantly improved serum SOD activities (p < 0.001) and reduced MDA (p < 0.001) and CRP (p < 0.001) concentrations compared with placebo. Quantitative data synthesis revealed a significant effect of curcuminoids vs. placebo in reducing circulating CRP concentrations (weighed mean difference: −2.20 mg/L; 95% confidence interval [CI]: −3.96, −0.44; p = 0.01). This effect was robust in sensitivity analysis. Conclusions Short-term supplementation with curcuminoid-piperine combination significantly improves oxidative and inflammatory status in patients with MetS. Curcuminoids could be regarded as natural, safe and effective CRP-lowering agents. Oxidative stress and inflammation have been proposed as emerging components of metabolic syndrome (MetS). Curcuminoids are natural polyphenols with strong antioxidant and anti-inflammatory properties. To study the effectiveness of supplementation with a bioavailable curcuminoid preparation on measures of oxidative stress and inflammation in patients with MetS. Our secondary aim was to perform a meta-analysis of data from all randomized controlled trials in order to estimate the effect size of curcuminoids on plasma C-reactive protein (CRP) concentrations. In this randomized double-blind placebo-controlled trial, 117 subjects with MetS (according to the NCEP-ATPIII diagnostic criteria) were randomly assigned to curcuminoids (n = 59; drop-outs = 9) or placebo (n = 58; drop-outs = 8) for eight weeks. Curcuminoids were administered at a daily dose of 1 g, and were co-supplemented with piperine (10 mg/day) in order to boost oral bioavailability. Serum activities of superoxide dismutase (SOD) and concentrations of malondialdehyde (MDA) and CRP were measured at baseline and at study end. Regarding the importance of CRP as a risk marker and risk factor of cardiovascular disease, a random-effects meta-analysis of clinical trials was performed to estimate the overall impact of curcuminoid therapy on circulating concentrations of CRP. The robustness of estimated effect size was evaluated using leave-one-out sensitivity analysis. Supplementation with curcuminoid-piperine combination significantly improved serum SOD activities (p < 0.001) and reduced MDA (p < 0.001) and CRP (p < 0.001) concentrations compared with placebo. Quantitative data synthesis revealed a significant effect of curcuminoids vs. placebo in reducing circulating CRP concentrations (weighed mean difference: −2.20 mg/L; 95% confidence interval [CI]: −3.96, −0.44; p = 0.01). This effect was robust in sensitivity analysis. Short-term supplementation with curcuminoid-piperine combination significantly improves oxidative and inflammatory status in patients with MetS. Curcuminoids could be regarded as natural, safe and effective CRP-lowering agents." @default.
• W1968744498 created "2016-06-24" @default.
• W1968744498 creator A5023108791 @default.
• W1968744498 creator A5032412684 @default.
• W1968744498 creator A5036163332 @default.
• W1968744498 creator A5067585337 @default.
• W1968744498 creator A5072994060 @default.
• W1968744498 creator A5085883608 @default.
• W1968744498 date "2015-12-01" @default.
• W1968744498 modified "2023-10-04" @default.
• W1968744498 title "Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis" @default.
• W1968744498 cites W1506756493 @default.
• W1968744498 cites W1507317003 @default.
• W1968744498 cites W1537972189 @default.
• W1968744498 cites W1569904453 @default.
• W1968744498 cites W1847692633 @default.
• W1968744498 cites W1914065146 @default.
• W1968744498 cites W1930004935 @default.
• W1968744498 cites W1944972564 @default.
• W1968744498 cites W1967105675 @default.
• W1968744498 cites W1969619218 @default.
• W1968744498 cites W1971456863 @default.
• W1968744498 cites W1985374023 @default.
• W1968744498 cites W1985900911 @default.
• W1968744498 cites W1997844179 @default.
• W1968744498 cites W1998552907 @default.
• W1968744498 cites W2000590423 @default.
• W1968744498 cites W2009236255 @default.
• W1968744498 cites W2010408706 @default.
• W1968744498 cites W2011534124 @default.
• W1968744498 cites W2017764127 @default.
• W1968744498 cites W2025107860 @default.
• W1968744498 cites W2048529677 @default.
• W1968744498 cites W2050064516 @default.
• W1968744498 cites W2056581676 @default.
• W1968744498 cites W2060662813 @default.
• W1968744498 cites W2060684271 @default.
• W1968744498 cites W2065612142 @default.
• W1968744498 cites W2067115104 @default.
• W1968744498 cites W2076018821 @default.
• W1968744498 cites W2077166822 @default.
• W1968744498 cites W2078446310 @default.
• W1968744498 cites W2092032160 @default.
• W1968744498 cites W2092629458 @default.
• W1968744498 cites W2094564938 @default.
• W1968744498 cites W2102192655 @default.
• W1968744498 cites W2103714496 @default.
• W1968744498 cites W2104967789 @default.
• W1968744498 cites W2109595793 @default.
• W1968744498 cites W2109690091 @default.
• W1968744498 cites W2113474990 @default.
• W1968744498 cites W2114047389 @default.
• W1968744498 cites W2123375980 @default.
• W1968744498 cites W2141515673 @default.
• W1968744498 cites W2141909270 @default.
• W1968744498 cites W2142635172 @default.
• W1968744498 cites W2142914294 @default.
• W1968744498 cites W2144430415 @default.
• W1968744498 cites W2144810869 @default.
• W1968744498 cites W2151660702 @default.
• W1968744498 cites W2155451482 @default.
• W1968744498 cites W2156755182 @default.
• W1968744498 cites W2160770872 @default.
• W1968744498 cites W2163581722 @default.
• W1968744498 cites W2164737140 @default.
• W1968744498 cites W2165404957 @default.
• W1968744498 cites W2168711527 @default.
• W1968744498 cites W2171282555 @default.
• W1968744498 cites W2171479615 @default.
• W1968744498 cites W2171735019 @default.
• W1968744498 cites W2330293594 @default.
• W1968744498 cites W2330863267 @default.
• W1968744498 cites W4238251256 @default.
• W1968744498 doi "https://doi.org/10.1016/j.clnu.2014.12.019" @default.
• W1968744498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25618800" @default.
• W1968744498 hasPublicationYear "2015" @default.
• W1968744498 type Work @default.
• W1968744498 sameAs 1968744498 @default.
• W1968744498 citedByCount "300" @default.
• W1968744498 countsByYear W19687444982014 @default.
• W1968744498 countsByYear W19687444982015 @default.
• W1968744498 countsByYear W19687444982016 @default.
• W1968744498 countsByYear W19687444982017 @default.
• W1968744498 countsByYear W19687444982018 @default.
• W1968744498 countsByYear W19687444982019 @default.
• W1968744498 countsByYear W19687444982020 @default.
• W1968744498 countsByYear W19687444982021 @default.
• W1968744498 countsByYear W19687444982022 @default.
• W1968744498 countsByYear W19687444982023 @default.
• W1968744498 crossrefType "journal-article" @default.
• W1968744498 hasAuthorship W1968744498A5023108791 @default.
• W1968744498 hasAuthorship W1968744498A5032412684 @default.
• W1968744498 hasAuthorship W1968744498A5036163332 @default.
• W1968744498 hasAuthorship W1968744498A5067585337 @default.
• W1968744498 hasAuthorship W1968744498A5072994060 @default.
• W1968744498 hasAuthorship W1968744498A5085883608 @default.
• W1968744498 hasConcept C126322002 @default.
• W1968744498 hasConcept C142724271 @default.

• next