FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968758411> ?p ?o ?g. }

• W1968758411 endingPage "172" @default.
• W1968758411 startingPage "168" @default.
• W1968758411 abstract "The crystallographic phase problem is the primary bottleneck encountered when attempting to solve macromolecular structures for which no close crystallographic structural homologues are known. Typically, isomorphous heavy-atom replacement and/or anomalous dispersion methods must be used in such cases to obtain experimentally-determined phases. Even three-dimensional NMR structures of the same macromolecule are often not sufficient to solve the crystallographic phase problem. RNA crystal structures present additional challenges due to greater difficulty in obtaining suitable heavy-atom derivatives. We present a unique approach to solve the phase problem for novel RNA crystal structures that has enjoyed a reasonable degree of success. This approach involves modeling only those portions of the RNA sequence whose structure can be predicted readily, i.e., the individual A-form helical regions and well-known stem-loop sub-structures. We have found that no prior knowledge of how the helices and other structural elements are arranged with respect to one another in three-dimensional space, or in some cases, even the sequence, is required to obtain a useable solution to the phase problem, using simultaneous molecular replacement of a set of generic helical RNA fragments." @default.
• W1968758411 created "2016-06-24" @default.
• W1968758411 creator A5000609526 @default.
• W1968758411 creator A5071066742 @default.
• W1968758411 creator A5090007432 @default.
• W1968758411 date "2010-10-01" @default.
• W1968758411 modified "2023-09-23" @default.
• W1968758411 title "Solving novel RNA structures using only secondary structural fragments" @default.
• W1968758411 cites W1994043530 @default.
• W1968758411 cites W1995017064 @default.
• W1968758411 cites W2009736453 @default.
• W1968758411 cites W2013083986 @default.
• W1968758411 cites W2015473376 @default.
• W1968758411 cites W2025706856 @default.
• W1968758411 cites W2028454407 @default.
• W1968758411 cites W2034075266 @default.
• W1968758411 cites W2044008636 @default.
• W1968758411 cites W2053197719 @default.
• W1968758411 cites W2080284797 @default.
• W1968758411 cites W2086708241 @default.
• W1968758411 cites W2087588307 @default.
• W1968758411 cites W2091200271 @default.
• W1968758411 cites W2101446086 @default.
• W1968758411 cites W2124026197 @default.
• W1968758411 cites W2141157874 @default.
• W1968758411 cites W2144081223 @default.
• W1968758411 cites W2160695434 @default.
• W1968758411 doi "https://doi.org/10.1016/j.ymeth.2010.06.011" @default.
• W1968758411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2948636" @default.
• W1968758411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20541014" @default.
• W1968758411 hasPublicationYear "2010" @default.
• W1968758411 type Work @default.
• W1968758411 sameAs 1968758411 @default.
• W1968758411 citedByCount "22" @default.
• W1968758411 countsByYear W19687584112012 @default.
• W1968758411 countsByYear W19687584112013 @default.
• W1968758411 countsByYear W19687584112014 @default.
• W1968758411 countsByYear W19687584112015 @default.
• W1968758411 countsByYear W19687584112016 @default.
• W1968758411 countsByYear W19687584112017 @default.
• W1968758411 countsByYear W19687584112018 @default.
• W1968758411 countsByYear W19687584112019 @default.
• W1968758411 countsByYear W19687584112020 @default.
• W1968758411 countsByYear W19687584112021 @default.
• W1968758411 crossrefType "journal-article" @default.
• W1968758411 hasAuthorship W1968758411A5000609526 @default.
• W1968758411 hasAuthorship W1968758411A5071066742 @default.
• W1968758411 hasAuthorship W1968758411A5090007432 @default.
• W1968758411 hasBestOaLocation W19687584112 @default.
• W1968758411 hasConcept C102056067 @default.
• W1968758411 hasConcept C104317684 @default.
• W1968758411 hasConcept C112247285 @default.
• W1968758411 hasConcept C115624301 @default.
• W1968758411 hasConcept C120665830 @default.
• W1968758411 hasConcept C121332964 @default.
• W1968758411 hasConcept C149635348 @default.
• W1968758411 hasConcept C167625842 @default.
• W1968758411 hasConcept C177264268 @default.
• W1968758411 hasConcept C178790620 @default.
• W1968758411 hasConcept C185592680 @default.
• W1968758411 hasConcept C199360897 @default.
• W1968758411 hasConcept C204389451 @default.
• W1968758411 hasConcept C207114421 @default.
• W1968758411 hasConcept C2777166331 @default.
• W1968758411 hasConcept C2778112365 @default.
• W1968758411 hasConcept C41008148 @default.
• W1968758411 hasConcept C44280652 @default.
• W1968758411 hasConcept C55493867 @default.
• W1968758411 hasConcept C58312451 @default.
• W1968758411 hasConcept C67705224 @default.
• W1968758411 hasConcept C8010536 @default.
• W1968758411 hasConceptScore W1968758411C102056067 @default.
• W1968758411 hasConceptScore W1968758411C104317684 @default.
• W1968758411 hasConceptScore W1968758411C112247285 @default.
• W1968758411 hasConceptScore W1968758411C115624301 @default.
• W1968758411 hasConceptScore W1968758411C120665830 @default.
• W1968758411 hasConceptScore W1968758411C121332964 @default.
• W1968758411 hasConceptScore W1968758411C149635348 @default.
• W1968758411 hasConceptScore W1968758411C167625842 @default.
• W1968758411 hasConceptScore W1968758411C177264268 @default.
• W1968758411 hasConceptScore W1968758411C178790620 @default.
• W1968758411 hasConceptScore W1968758411C185592680 @default.
• W1968758411 hasConceptScore W1968758411C199360897 @default.
• W1968758411 hasConceptScore W1968758411C204389451 @default.
• W1968758411 hasConceptScore W1968758411C207114421 @default.
• W1968758411 hasConceptScore W1968758411C2777166331 @default.
• W1968758411 hasConceptScore W1968758411C2778112365 @default.
• W1968758411 hasConceptScore W1968758411C41008148 @default.
• W1968758411 hasConceptScore W1968758411C44280652 @default.
• W1968758411 hasConceptScore W1968758411C55493867 @default.
• W1968758411 hasConceptScore W1968758411C58312451 @default.
• W1968758411 hasConceptScore W1968758411C67705224 @default.
• W1968758411 hasConceptScore W1968758411C8010536 @default.
• W1968758411 hasIssue "2" @default.
• W1968758411 hasLocation W19687584111 @default.
• W1968758411 hasLocation W19687584112 @default.
• W1968758411 hasLocation W19687584113 @default.
• W1968758411 hasLocation W19687584114 @default.

• next