Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968766198> ?p ?o ?g. }
- W1968766198 abstract "The dietary protein requirements of patients with insulin-dependent diabetes mellitus (IDDM) are unknown. We studied the metabolic adaptation of IDDM patients with early nephropathy to therapeutic, low-protein diets. Six patients were studied at baseline and following 1 and 12 weeks of consuming 0.6 g/kg-1 ideal body weight.day-1 protein. Outcome variables included quadriceps muscle strength, body composition, nitrogen balance, and estimates of whole body protein turnover using an infusion of L-[1-13C]leucine. All subjects experienced decreased muscle strength (6.6% decline in maximal torque, P = 0.05) and increased body fatness (11% increase in fat mass, P = 0.03) with no change in total body weight. This was accompanied by an initial 40% decrease in the rate of whole-body leucine oxidation after 1 week of dietary restriction which returned almost to baseline rates by 12 weeks (P less than 0.001, 1 week vs. 12 weeks). Nitrogen balance remained negative throughout the period of protein restriction. We conclude that IDDM subjects with early nephropathy experience protein undernutrition during the first 3 months of the dietary protein restriction currently recommended for the treatment of nephropathy. This may result, in part, from an inability to conserve essential amino acids from oxidative loss over the time period of the study." @default.
- W1968766198 created "2016-06-24" @default.
- W1968766198 creator A5028084259 @default.
- W1968766198 creator A5052394716 @default.
- W1968766198 creator A5060714709 @default.
- W1968766198 creator A5073185556 @default.
- W1968766198 creator A5073944024 @default.
- W1968766198 creator A5077822780 @default.
- W1968766198 date "1992-08-01" @default.
- W1968766198 modified "2023-10-14" @default.
- W1968766198 title "Effects of low-protein diets on protein metabolism in insulin-dependent diabetes mellitus patients with early nephropathy." @default.
- W1968766198 cites W1808750587 @default.
- W1968766198 cites W1876326874 @default.
- W1968766198 cites W1943967655 @default.
- W1968766198 cites W1987314503 @default.
- W1968766198 cites W2003485079 @default.
- W1968766198 cites W2005876834 @default.
- W1968766198 cites W2015177663 @default.
- W1968766198 cites W2025771789 @default.
- W1968766198 cites W2065544193 @default.
- W1968766198 cites W2067236139 @default.
- W1968766198 cites W2075787199 @default.
- W1968766198 cites W2094769502 @default.
- W1968766198 cites W2129686285 @default.
- W1968766198 cites W2162254318 @default.
- W1968766198 cites W2162984461 @default.
- W1968766198 cites W2194515881 @default.
- W1968766198 cites W2300518744 @default.
- W1968766198 cites W2330121013 @default.
- W1968766198 cites W2417058727 @default.
- W1968766198 cites W2471980070 @default.
- W1968766198 doi "https://doi.org/10.1210/jcem.75.2.1639934" @default.
- W1968766198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1639934" @default.
- W1968766198 hasPublicationYear "1992" @default.
- W1968766198 type Work @default.
- W1968766198 sameAs 1968766198 @default.
- W1968766198 citedByCount "21" @default.
- W1968766198 countsByYear W19687661982013 @default.
- W1968766198 countsByYear W19687661982015 @default.
- W1968766198 countsByYear W19687661982018 @default.
- W1968766198 crossrefType "journal-article" @default.
- W1968766198 hasAuthorship W1968766198A5028084259 @default.
- W1968766198 hasAuthorship W1968766198A5052394716 @default.
- W1968766198 hasAuthorship W1968766198A5060714709 @default.
- W1968766198 hasAuthorship W1968766198A5073185556 @default.
- W1968766198 hasAuthorship W1968766198A5073944024 @default.
- W1968766198 hasAuthorship W1968766198A5077822780 @default.
- W1968766198 hasConcept C126322002 @default.
- W1968766198 hasConcept C134018914 @default.
- W1968766198 hasConcept C178790620 @default.
- W1968766198 hasConcept C185592680 @default.
- W1968766198 hasConcept C195580219 @default.
- W1968766198 hasConcept C2776580952 @default.
- W1968766198 hasConcept C2777573094 @default.
- W1968766198 hasConcept C2777661713 @default.
- W1968766198 hasConcept C2779306644 @default.
- W1968766198 hasConcept C2779572773 @default.
- W1968766198 hasConcept C2779922275 @default.
- W1968766198 hasConcept C2781184683 @default.
- W1968766198 hasConcept C3675279 @default.
- W1968766198 hasConcept C515207424 @default.
- W1968766198 hasConcept C537208039 @default.
- W1968766198 hasConcept C55493867 @default.
- W1968766198 hasConcept C555293320 @default.
- W1968766198 hasConcept C62231903 @default.
- W1968766198 hasConcept C71924100 @default.
- W1968766198 hasConcept C8101879 @default.
- W1968766198 hasConcept C86803240 @default.
- W1968766198 hasConceptScore W1968766198C126322002 @default.
- W1968766198 hasConceptScore W1968766198C134018914 @default.
- W1968766198 hasConceptScore W1968766198C178790620 @default.
- W1968766198 hasConceptScore W1968766198C185592680 @default.
- W1968766198 hasConceptScore W1968766198C195580219 @default.
- W1968766198 hasConceptScore W1968766198C2776580952 @default.
- W1968766198 hasConceptScore W1968766198C2777573094 @default.
- W1968766198 hasConceptScore W1968766198C2777661713 @default.
- W1968766198 hasConceptScore W1968766198C2779306644 @default.
- W1968766198 hasConceptScore W1968766198C2779572773 @default.
- W1968766198 hasConceptScore W1968766198C2779922275 @default.
- W1968766198 hasConceptScore W1968766198C2781184683 @default.
- W1968766198 hasConceptScore W1968766198C3675279 @default.
- W1968766198 hasConceptScore W1968766198C515207424 @default.
- W1968766198 hasConceptScore W1968766198C537208039 @default.
- W1968766198 hasConceptScore W1968766198C55493867 @default.
- W1968766198 hasConceptScore W1968766198C555293320 @default.
- W1968766198 hasConceptScore W1968766198C62231903 @default.
- W1968766198 hasConceptScore W1968766198C71924100 @default.
- W1968766198 hasConceptScore W1968766198C8101879 @default.
- W1968766198 hasConceptScore W1968766198C86803240 @default.
- W1968766198 hasLocation W19687661981 @default.
- W1968766198 hasLocation W19687661982 @default.
- W1968766198 hasOpenAccess W1968766198 @default.
- W1968766198 hasPrimaryLocation W19687661981 @default.
- W1968766198 hasRelatedWork W1902674369 @default.
- W1968766198 hasRelatedWork W1968766198 @default.
- W1968766198 hasRelatedWork W2026749284 @default.
- W1968766198 hasRelatedWork W2101250856 @default.
- W1968766198 hasRelatedWork W2118800397 @default.
- W1968766198 hasRelatedWork W2150060524 @default.
- W1968766198 hasRelatedWork W2267552762 @default.