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- W1968766632 abstract "In cell-extracellular matrix junctions (focal adhesions), the cytoskeletal protein talin is central to the connection of integrins to the actin cytoskeleton. Talin is thought to mediate this connection via its two integrin, (at least) three actin, and several vinculin binding sites. The binding sites are cryptic in the head-to-rod autoinhibited cytoplasmic form of the protein and require (stepwise) conformational activation. This activation process, however, remains poorly understood, and there are contradictory models with respect to the determinants of adhesion site localization. Here, we report turnover rates and protein-protein interactions in a range of talin rod domain constructs varying in helix bundle structure. We conclude that several bundles of the C terminus cooperate to regulate targeting and concomitantly tailor high affinity interactions of the talin rod in cell adhesions. Intrinsic control of ligand binding activities is essential for the coordination of adhesion site function of talin." @default.
- W1968766632 created "2016-06-24" @default.
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- W1968766632 date "2009-05-01" @default.
- W1968766632 modified "2023-10-16" @default.
- W1968766632 title "Control of High Affinity Interactions in the Talin C Terminus" @default.
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- W1968766632 doi "https://doi.org/10.1074/jbc.m900266200" @default.
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