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- W1968771804 abstract "Over the past two decades we have seen some truly exciting advances made in the biological understanding, diagnosis and management of breast cancer. We now recognise that breast cancer is a heterogeneous disease made of up of several subtypes. The introduction of an anthracycline polychemotherapy adjuvant regimen has reduced the 10-year breast cancer mortality by approximately one-third and the introduction of the monoclonal antibody trastuzumab for the treatment of HER2-positive breast cancer has in the adjuvant setting been associated with an unprecedented relative improvement in disease-free survival by almost 50%. Research is now focused on further improving prognostic outcome by exploring novel biomarkers that will better select patients requiring chemotherapy, identification and development of agents to overcome primary and secondary resistance of tumours to existing therapeutic agents as well as introducing new more efficacious chemotherapeutic and biological agents into adjuvant treatment protocols." @default.
- W1968771804 created "2016-06-24" @default.
- W1968771804 creator A5046206676 @default.
- W1968771804 date "2013-03-01" @default.
- W1968771804 modified "2023-10-09" @default.
- W1968771804 title "Pathology vs medical oncology: the crucial exchange of accurate information" @default.
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- W1968771804 doi "https://doi.org/10.1038/bjc.2013.23" @default.
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