FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968772869> ?p ?o ?g. }

• W1968772869 endingPage "310" @default.
• W1968772869 startingPage "299" @default.
• W1968772869 abstract "Radioligand binding studies were used to define the binding constants for inhibition of [125I]endothelin-1 binding by endothelin-1 (ET-1), endothelin-3 (ET-3) and a synthetic analogue of ET-1, [Ala1,3,11,15]ET-1 in rat aorta and cerebellum. The inhibition curves for the three substances were similar in the cerebellum (Ki, ET-1 = ET-3 = [Ala1,3,11,15]ET-1) but differed in the aorta (Ki, ET-1 <<< [Ala1,3,11,15]ET-1) with the ET-3 inhibition curves being biphasic, indicating binding to two sites. In functional studies in the aorta, in contrast to findings in the cerebellum, [Ala1,3,11,15]ET-1 was inactive and ET-3 was a partial agonist. These findings support the idea of heterogeneity of endothelin receptors. Autoradiographic studies were performed to identify the cellular localisation of endothelin-1 receptors in the two tissues. In the aorta binding was to all elements of the vasculature including the endothelium, smooth muscle, periadventitial connective tissue and nerves. In the cerebellum binding sites were located predominantly over the neuronal elements of the granular cell layer. The cellular localisation of the high and low affinity sites for ET-3, and the functional significance of the high affinity binding site for ET-3, remain to be determined." @default.
• W1968772869 created "2016-06-24" @default.
• W1968772869 creator A5002799279 @default.
• W1968772869 creator A5006097047 @default.
• W1968772869 creator A5030966405 @default.
• W1968772869 creator A5070464366 @default.
• W1968772869 date "1991-01-01" @default.
• W1968772869 modified "2023-10-16" @default.
• W1968772869 title "Endothelin Receptor Heterogeneity; Structure Activity, Autoradiographic and Functional Studies" @default.
• W1968772869 cites W1976046184 @default.
• W1968772869 cites W1976055714 @default.
• W1968772869 cites W1990386820 @default.
• W1968772869 cites W2007924364 @default.
• W1968772869 cites W2011348280 @default.
• W1968772869 cites W2018522064 @default.
• W1968772869 cites W2020062617 @default.
• W1968772869 cites W2029995229 @default.
• W1968772869 cites W2035980061 @default.
• W1968772869 cites W2043813981 @default.
• W1968772869 cites W2046373025 @default.
• W1968772869 cites W2049349715 @default.
• W1968772869 cites W2051289134 @default.
• W1968772869 cites W2055679500 @default.
• W1968772869 cites W2061739188 @default.
• W1968772869 cites W2065569694 @default.
• W1968772869 cites W2065895639 @default.
• W1968772869 cites W2080945292 @default.
• W1968772869 cites W2081829051 @default.
• W1968772869 cites W2088611940 @default.
• W1968772869 cites W2095029478 @default.
• W1968772869 cites W2123497769 @default.
• W1968772869 cites W2126047256 @default.
• W1968772869 cites W2160809462 @default.
• W1968772869 cites W2162804111 @default.
• W1968772869 cites W2281938476 @default.
• W1968772869 cites W2336208433 @default.
• W1968772869 cites W2400305401 @default.
• W1968772869 doi "https://doi.org/10.3109/10799899109066409" @default.
• W1968772869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1653336" @default.
• W1968772869 hasPublicationYear "1991" @default.
• W1968772869 type Work @default.
• W1968772869 sameAs 1968772869 @default.
• W1968772869 citedByCount "23" @default.
• W1968772869 countsByYear W19687728692015 @default.
• W1968772869 countsByYear W19687728692023 @default.
• W1968772869 crossrefType "journal-article" @default.
• W1968772869 hasAuthorship W1968772869A5002799279 @default.
• W1968772869 hasAuthorship W1968772869A5006097047 @default.
• W1968772869 hasAuthorship W1968772869A5030966405 @default.
• W1968772869 hasAuthorship W1968772869A5070464366 @default.
• W1968772869 hasConcept C105702510 @default.
• W1968772869 hasConcept C107824862 @default.
• W1968772869 hasConcept C12554922 @default.
• W1968772869 hasConcept C126322002 @default.
• W1968772869 hasConcept C134018914 @default.
• W1968772869 hasConcept C144980905 @default.
• W1968772869 hasConcept C149601957 @default.
• W1968772869 hasConcept C170493617 @default.
• W1968772869 hasConcept C185592680 @default.
• W1968772869 hasConcept C2776992346 @default.
• W1968772869 hasConcept C2778938600 @default.
• W1968772869 hasConcept C2779652256 @default.
• W1968772869 hasConcept C2779980429 @default.
• W1968772869 hasConcept C2909649922 @default.
• W1968772869 hasConcept C55493867 @default.
• W1968772869 hasConcept C67847695 @default.
• W1968772869 hasConcept C71924100 @default.
• W1968772869 hasConcept C86803240 @default.
• W1968772869 hasConcept C95444343 @default.
• W1968772869 hasConceptScore W1968772869C105702510 @default.
• W1968772869 hasConceptScore W1968772869C107824862 @default.
• W1968772869 hasConceptScore W1968772869C12554922 @default.
• W1968772869 hasConceptScore W1968772869C126322002 @default.
• W1968772869 hasConceptScore W1968772869C134018914 @default.
• W1968772869 hasConceptScore W1968772869C144980905 @default.
• W1968772869 hasConceptScore W1968772869C149601957 @default.
• W1968772869 hasConceptScore W1968772869C170493617 @default.
• W1968772869 hasConceptScore W1968772869C185592680 @default.
• W1968772869 hasConceptScore W1968772869C2776992346 @default.
• W1968772869 hasConceptScore W1968772869C2778938600 @default.
• W1968772869 hasConceptScore W1968772869C2779652256 @default.
• W1968772869 hasConceptScore W1968772869C2779980429 @default.
• W1968772869 hasConceptScore W1968772869C2909649922 @default.
• W1968772869 hasConceptScore W1968772869C55493867 @default.
• W1968772869 hasConceptScore W1968772869C67847695 @default.
• W1968772869 hasConceptScore W1968772869C71924100 @default.
• W1968772869 hasConceptScore W1968772869C86803240 @default.
• W1968772869 hasConceptScore W1968772869C95444343 @default.
• W1968772869 hasIssue "1-4" @default.
• W1968772869 hasLocation W19687728691 @default.
• W1968772869 hasLocation W19687728692 @default.
• W1968772869 hasOpenAccess W1968772869 @default.
• W1968772869 hasPrimaryLocation W19687728691 @default.
• W1968772869 hasRelatedWork W1968772869 @default.
• W1968772869 hasRelatedWork W2009892925 @default.
• W1968772869 hasRelatedWork W2035212172 @default.
• W1968772869 hasRelatedWork W2040913792 @default.
• W1968772869 hasRelatedWork W2094867358 @default.

• next