FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968773075> ?p ?o ?g. }

• W1968773075 endingPage "2079" @default.
• W1968773075 startingPage "2074" @default.
• W1968773075 abstract "Blocking cell division through the inhibition of mitosis is one of the most successful clinical strategies for the treatment of cancer. Taxanes and vinca alkaloids are in widespread use and have demonstrated substantive therapeutic efficacy. Both classes of compounds bind directly to tubulin, a structural component of the mitotic spindle. The ubiquitous utilization of tubulin in cell division in both cancerous and normal cells, however, tempers the broad spectrum of activity of currently used antimitotics by significant toxicities in normal dividing tissue. Moreover, peripheral nerve cells that rely on microtubules to shuttle cargo along axonal processes are also damaged by tubulin-binding drugs. Thus, neutropenia and peripheral neuropathy are the most frequently cited dose-limiting toxicities of this class of chemotherapeutics. Here we report the preclinical assessment of AB-5, a structural and functional analog of the natural product diazonamide A. AB-5, like taxanes and vinca alkaloids, blocks cell division during mitosis. However, AB-5 works not by binding tubulin but rather through inhibition of a newly discovered role for ornithine-δ-aminotransferase in mitosis. We hereby report that, unlike other antimitotics, AB-5 is extremely well tolerated by mice when administered under conditions where the drug cures xenografted tumors as effectively as taxanes and vinca alkaloids. AB-5-treated mice show no weight loss, no change in overall physical appearance, and no evidence of neutropenia. These observations raise the possibility that AB-5 may have clinical utility for cancer therapy under conditions largely devoid of chemotherapeutic toxicity and suggest that further preclinical evaluation of AB-5 is warranted." @default.
• W1968773075 created "2016-06-24" @default.
• W1968773075 creator A5001736863 @default.
• W1968773075 creator A5015543492 @default.
• W1968773075 creator A5033303405 @default.
• W1968773075 creator A5040205022 @default.
• W1968773075 creator A5078046631 @default.
• W1968773075 creator A5089880476 @default.
• W1968773075 date "2007-02-13" @default.
• W1968773075 modified "2023-10-10" @default.
• W1968773075 title "Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity" @default.
• W1968773075 cites W1541952204 @default.
• W1968773075 cites W1972561210 @default.
• W1968773075 cites W1979894632 @default.
• W1968773075 cites W1983347917 @default.
• W1968773075 cites W1983496231 @default.
• W1968773075 cites W1985384141 @default.
• W1968773075 cites W1992820423 @default.
• W1968773075 cites W2027509917 @default.
• W1968773075 cites W2032860131 @default.
• W1968773075 cites W2053991217 @default.
• W1968773075 cites W2067299834 @default.
• W1968773075 cites W2106521963 @default.
• W1968773075 cites W2110183632 @default.
• W1968773075 cites W2110831567 @default.
• W1968773075 cites W2115865112 @default.
• W1968773075 cites W2117973016 @default.
• W1968773075 cites W2162701869 @default.
• W1968773075 cites W2163978496 @default.
• W1968773075 cites W2171623191 @default.
• W1968773075 cites W2952028208 @default.
• W1968773075 doi "https://doi.org/10.1073/pnas.0611340104" @default.
• W1968773075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1794345" @default.
• W1968773075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17287337" @default.
• W1968773075 hasPublicationYear "2007" @default.
• W1968773075 type Work @default.
• W1968773075 sameAs 1968773075 @default.
• W1968773075 citedByCount "58" @default.
• W1968773075 countsByYear W19687730752012 @default.
• W1968773075 countsByYear W19687730752013 @default.
• W1968773075 countsByYear W19687730752014 @default.
• W1968773075 countsByYear W19687730752015 @default.
• W1968773075 countsByYear W19687730752016 @default.
• W1968773075 countsByYear W19687730752017 @default.
• W1968773075 countsByYear W19687730752018 @default.
• W1968773075 countsByYear W19687730752019 @default.
• W1968773075 countsByYear W19687730752020 @default.
• W1968773075 countsByYear W19687730752022 @default.
• W1968773075 crossrefType "journal-article" @default.
• W1968773075 hasAuthorship W1968773075A5001736863 @default.
• W1968773075 hasAuthorship W1968773075A5015543492 @default.
• W1968773075 hasAuthorship W1968773075A5033303405 @default.
• W1968773075 hasAuthorship W1968773075A5040205022 @default.
• W1968773075 hasAuthorship W1968773075A5078046631 @default.
• W1968773075 hasAuthorship W1968773075A5089880476 @default.
• W1968773075 hasBestOaLocation W19687730752 @default.
• W1968773075 hasConcept C126322002 @default.
• W1968773075 hasConcept C1491633281 @default.
• W1968773075 hasConcept C20418707 @default.
• W1968773075 hasConcept C2776553716 @default.
• W1968773075 hasConcept C2776694085 @default.
• W1968773075 hasConcept C2776755627 @default.
• W1968773075 hasConcept C2777096885 @default.
• W1968773075 hasConcept C2779429289 @default.
• W1968773075 hasConcept C29730261 @default.
• W1968773075 hasConcept C47432576 @default.
• W1968773075 hasConcept C502942594 @default.
• W1968773075 hasConcept C54355233 @default.
• W1968773075 hasConcept C55493867 @default.
• W1968773075 hasConcept C71924100 @default.
• W1968773075 hasConcept C84425145 @default.
• W1968773075 hasConcept C85813293 @default.
• W1968773075 hasConcept C86803240 @default.
• W1968773075 hasConcept C93304396 @default.
• W1968773075 hasConcept C95444343 @default.
• W1968773075 hasConcept C98274493 @default.
• W1968773075 hasConceptScore W1968773075C126322002 @default.
• W1968773075 hasConceptScore W1968773075C1491633281 @default.
• W1968773075 hasConceptScore W1968773075C20418707 @default.
• W1968773075 hasConceptScore W1968773075C2776553716 @default.
• W1968773075 hasConceptScore W1968773075C2776694085 @default.
• W1968773075 hasConceptScore W1968773075C2776755627 @default.
• W1968773075 hasConceptScore W1968773075C2777096885 @default.
• W1968773075 hasConceptScore W1968773075C2779429289 @default.
• W1968773075 hasConceptScore W1968773075C29730261 @default.
• W1968773075 hasConceptScore W1968773075C47432576 @default.
• W1968773075 hasConceptScore W1968773075C502942594 @default.
• W1968773075 hasConceptScore W1968773075C54355233 @default.
• W1968773075 hasConceptScore W1968773075C55493867 @default.
• W1968773075 hasConceptScore W1968773075C71924100 @default.
• W1968773075 hasConceptScore W1968773075C84425145 @default.
• W1968773075 hasConceptScore W1968773075C85813293 @default.
• W1968773075 hasConceptScore W1968773075C86803240 @default.
• W1968773075 hasConceptScore W1968773075C93304396 @default.
• W1968773075 hasConceptScore W1968773075C95444343 @default.
• W1968773075 hasConceptScore W1968773075C98274493 @default.
• W1968773075 hasIssue "7" @default.
• W1968773075 hasLocation W19687730751 @default.

• next