FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968773604> ?p ?o ?g. }

• W1968773604 abstract "During somatic hypermutation (SHM), activation-induced deaminase (AID) mutates deoxycytidine on single-stranded DNA (ssDNA) generated by the transcription machinery, but the detailed mechanism remains unclear. Here we report a higher abundance of RNA polymerase II (Pol II) at the immunoglobulin heavy-chain variable (Igh-V) region compared with the constant region and partially transcribed Igh RNAs, suggesting a slower Pol II progression at Igh-V that could result in some early/premature transcription termination after prolonged pausing/stalling of Pol II. Knocking down RNA-exosome complexes, which could decrease premature transcription termination, leads to decreased SHM. Knocking down Spt5, which can augment premature transcription termination, leads to increase in both, SHM and the abundance of ssDNA substrates. Collectively, our data support the model that, following the reduction of Pol II progression (pausing or stalling) at the Igh-V, additional steps such as premature transcription termination are involved in providing ssDNA substrates for AID during SHM." @default.
• W1968773604 created "2016-06-24" @default.
• W1968773604 creator A5002822549 @default.
• W1968773604 creator A5024371287 @default.
• W1968773604 creator A5048919402 @default.
• W1968773604 creator A5057781262 @default.
• W1968773604 creator A5074900624 @default.
• W1968773604 date "2014-06-13" @default.
• W1968773604 modified "2023-10-11" @default.
• W1968773604 title "A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation" @default.
• W1968773604 cites W1965512560 @default.
• W1968773604 cites W1968613668 @default.
• W1968773604 cites W1972397361 @default.
• W1968773604 cites W1974325040 @default.
• W1968773604 cites W1981915772 @default.
• W1968773604 cites W1985264665 @default.
• W1968773604 cites W1991098988 @default.
• W1968773604 cites W2002043709 @default.
• W1968773604 cites W2005382148 @default.
• W1968773604 cites W2005982219 @default.
• W1968773604 cites W2006123144 @default.
• W1968773604 cites W2007844697 @default.
• W1968773604 cites W2013721615 @default.
• W1968773604 cites W2017629702 @default.
• W1968773604 cites W2028845769 @default.
• W1968773604 cites W2031263707 @default.
• W1968773604 cites W2036806870 @default.
• W1968773604 cites W2038824730 @default.
• W1968773604 cites W2042639249 @default.
• W1968773604 cites W2061025027 @default.
• W1968773604 cites W2061265134 @default.
• W1968773604 cites W2062738638 @default.
• W1968773604 cites W2064210252 @default.
• W1968773604 cites W2067659875 @default.
• W1968773604 cites W2079493448 @default.
• W1968773604 cites W2090449194 @default.
• W1968773604 cites W2091042776 @default.
• W1968773604 cites W2094094914 @default.
• W1968773604 cites W2097335909 @default.
• W1968773604 cites W2098309323 @default.
• W1968773604 cites W2098739051 @default.
• W1968773604 cites W2100392760 @default.
• W1968773604 cites W2101513821 @default.
• W1968773604 cites W2107861779 @default.
• W1968773604 cites W2115897508 @default.
• W1968773604 cites W2117973542 @default.
• W1968773604 cites W2121647638 @default.
• W1968773604 cites W2126233054 @default.
• W1968773604 cites W2127462192 @default.
• W1968773604 cites W2129214044 @default.
• W1968773604 cites W2139664433 @default.
• W1968773604 cites W2141675922 @default.
• W1968773604 cites W2154841949 @default.
• W1968773604 cites W2155538892 @default.
• W1968773604 cites W2157577917 @default.
• W1968773604 cites W2164201819 @default.
• W1968773604 cites W2165608602 @default.
• W1968773604 cites W2166573244 @default.
• W1968773604 cites W2169107624 @default.
• W1968773604 cites W4246504300 @default.
• W1968773604 cites W4251633039 @default.
• W1968773604 doi "https://doi.org/10.1038/ncomms5137" @default.
• W1968773604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4154566" @default.
• W1968773604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24923561" @default.
• W1968773604 hasPublicationYear "2014" @default.
• W1968773604 type Work @default.
• W1968773604 sameAs 1968773604 @default.
• W1968773604 citedByCount "29" @default.
• W1968773604 countsByYear W19687736042014 @default.
• W1968773604 countsByYear W19687736042015 @default.
• W1968773604 countsByYear W19687736042016 @default.
• W1968773604 countsByYear W19687736042017 @default.
• W1968773604 countsByYear W19687736042018 @default.
• W1968773604 countsByYear W19687736042019 @default.
• W1968773604 countsByYear W19687736042020 @default.
• W1968773604 countsByYear W19687736042021 @default.
• W1968773604 countsByYear W19687736042022 @default.
• W1968773604 crossrefType "journal-article" @default.
• W1968773604 hasAuthorship W1968773604A5002822549 @default.
• W1968773604 hasAuthorship W1968773604A5024371287 @default.
• W1968773604 hasAuthorship W1968773604A5048919402 @default.
• W1968773604 hasAuthorship W1968773604A5057781262 @default.
• W1968773604 hasAuthorship W1968773604A5074900624 @default.
• W1968773604 hasBestOaLocation W19687736041 @default.
• W1968773604 hasConcept C101762097 @default.
• W1968773604 hasConcept C104317684 @default.
• W1968773604 hasConcept C128526571 @default.
• W1968773604 hasConcept C138885662 @default.
• W1968773604 hasConcept C150194340 @default.
• W1968773604 hasConcept C153911025 @default.
• W1968773604 hasConcept C159654299 @default.
• W1968773604 hasConcept C179926584 @default.
• W1968773604 hasConcept C185592680 @default.
• W1968773604 hasConcept C2776985229 @default.
• W1968773604 hasConcept C2778453870 @default.
• W1968773604 hasConcept C41895202 @default.
• W1968773604 hasConcept C54355233 @default.
• W1968773604 hasConcept C552990157 @default.
• W1968773604 hasConcept C64350747 @default.
• W1968773604 hasConcept C86803240 @default.

• next