FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968782753> ?p ?o ?g. }

• W1968782753 endingPage "171" @default.
• W1968782753 startingPage "165" @default.
• W1968782753 abstract "Rejection of transplanted liver occurs when the host generates alloantigen-reactive T cells, and CD4(+) T-cell subsets, including Th1, Th2, T17 and iTreg, could be involved in changing the dynamics of graft rejection onset. In the current immunosuppressive strategies, rejection is treated as an undifferentiated process that is uniform, which results in the failure of tolerance induction. Here, we established a rejection model to observe the reciprocal interaction of CD4(+) T-cell subsets in the complex networks of the immune system.Orthotopic liver transplantation (OLT) from male inbred Lewis rats (n=15) to male inbred Brown Norway (BN) rats was performed by Kamada's two-cuff technique without reconstruction of the hepatic artery. OLT from BN to BN rats (n=5) was performed as a control. Recipients were sacrificed on postoperative days 3, 5, 7, 9, 11, 13 and 15. Recipient spleens and grafts were harvested, fixed in 10% neutral formalin, and embedded in paraffin. Meanwhile, hematoxylin and eosin and immunohistochemical staining was done, acute rejection was graded by the Banff scheme, and the number of T-bet(+), GATA-3(+), RORgammat(+) and FOXP3(+) cells in the spleen and grafts were counted.In recipient spleens, the T-bet(+) and RORgammat(+) cells were increased more significantly in the mild acute rejection (AR) group than in the control group (P=0.016, P=0.009, respectively), while both cell types were decreased in the moderate AR group. Compared with the control group, the RORgammat(+) cells did not differ significantly in the severe AR group, while the T-bet(+) cells were significantly decreased (P=0.465, P=0.009, respectively). The GATA-3(+) cells were significantly decreased in the mild AR group compared with the control group (P=0.009). With regard to the FOXP3(+) cells, there was no significant difference between the control and mild AR groups (P=0.754), while they were significantly decreased in the moderate and severe AR groups (P=0.028, P=0.009, respectively). The ratio of T-bet(+)/GATA-3(+) cells was more associated with AR than was the RORgammat(+)/FOXP3(+) cell ratio in the early stage. In the graft, the T-bet(+) and RORgammat(+) cells were significantly increased in mild, moderate and severe AR groups compared with the control group (P<0.009). The expression of GATA-3(+) cell was not significantly increased in the mild AR group compared with the control group, while it was significantly increased in the moderate and severe AR groups (P=0.028, P=0.009, respectively). Concerning the FOXP3(+) cells, no significant difference was found between the control and mild AR groups (P=0.347), while they were significantly increased in the moderate and severe AR groups (P<0.009).Our study revealed the dynamic changes of T-bet(+), GATA-3(+), RORgammat(+) and FOXP3(+) cells in the spleen and grafts of recipient rats. It seems that the ratio of T-bet(+)/GATA-3(+) cells was more associated with AR than was RORgammat(+)/FOXP3(+) cells in the early stage of rejection, while the ratio of RORgammat(+)/FOXP3(+) cells was associated more with the later but more persistent stage of rejection. This study could make a contribution to the optimal selection of immunosuppressive regimens according to the dynamic changes in CD4(+) T-cell subsets at different stages of rejection." @default.
• W1968782753 created "2016-06-24" @default.
• W1968782753 creator A5006719547 @default.
• W1968782753 creator A5011835067 @default.
• W1968782753 creator A5018459204 @default.
• W1968782753 creator A5029634246 @default.
• W1968782753 creator A5036159697 @default.
• W1968782753 creator A5044742215 @default.
• W1968782753 creator A5049840120 @default.
• W1968782753 creator A5054508795 @default.
• W1968782753 creator A5066029512 @default.
• W1968782753 creator A5088539918 @default.
• W1968782753 date "2010-02-01" @default.
• W1968782753 modified "2023-09-22" @default.
• W1968782753 title "The dynamic changes of T-bet+/GATA-3+ and RORγt+/FOXP3+ cells in recipient spleens and grafts after rat orthotopic liver transplantation" @default.
• W1968782753 cites W1526879038 @default.
• W1968782753 cites W1534237017 @default.
• W1968782753 cites W1576161048 @default.
• W1968782753 cites W1581554632 @default.
• W1968782753 cites W1908103064 @default.
• W1968782753 cites W1967261754 @default.
• W1968782753 cites W1969228293 @default.
• W1968782753 cites W1977180934 @default.
• W1968782753 cites W1984909066 @default.
• W1968782753 cites W1986527938 @default.
• W1968782753 cites W2007674171 @default.
• W1968782753 cites W2017217637 @default.
• W1968782753 cites W2018008269 @default.
• W1968782753 cites W2019255130 @default.
• W1968782753 cites W2022212944 @default.
• W1968782753 cites W2027699993 @default.
• W1968782753 cites W2028016355 @default.
• W1968782753 cites W2031122515 @default.
• W1968782753 cites W2045904496 @default.
• W1968782753 cites W2049372707 @default.
• W1968782753 cites W2054083392 @default.
• W1968782753 cites W2060147676 @default.
• W1968782753 cites W2060937867 @default.
• W1968782753 cites W2064576452 @default.
• W1968782753 cites W2072320859 @default.
• W1968782753 cites W2077492907 @default.
• W1968782753 cites W2087851913 @default.
• W1968782753 cites W2097113319 @default.
• W1968782753 cites W2097811455 @default.
• W1968782753 cites W2101230909 @default.
• W1968782753 cites W2101771134 @default.
• W1968782753 cites W2103372729 @default.
• W1968782753 cites W2115785513 @default.
• W1968782753 cites W2122445377 @default.
• W1968782753 cites W2124116262 @default.
• W1968782753 cites W2125786054 @default.
• W1968782753 cites W2128475635 @default.
• W1968782753 cites W2131678280 @default.
• W1968782753 cites W2142017607 @default.
• W1968782753 cites W2148245227 @default.
• W1968782753 cites W2150026400 @default.
• W1968782753 cites W2158854771 @default.
• W1968782753 cites W2160883911 @default.
• W1968782753 cites W2163721979 @default.
• W1968782753 cites W4211218508 @default.
• W1968782753 cites W4243998405 @default.
• W1968782753 cites W4295201567 @default.
• W1968782753 doi "https://doi.org/10.1016/j.trim.2009.11.003" @default.
• W1968782753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19922796" @default.
• W1968782753 hasPublicationYear "2010" @default.
• W1968782753 type Work @default.
• W1968782753 sameAs 1968782753 @default.
• W1968782753 citedByCount "7" @default.
• W1968782753 countsByYear W19687827532012 @default.
• W1968782753 countsByYear W19687827532013 @default.
• W1968782753 countsByYear W19687827532017 @default.
• W1968782753 countsByYear W19687827532018 @default.
• W1968782753 countsByYear W19687827532020 @default.
• W1968782753 crossrefType "journal-article" @default.
• W1968782753 hasAuthorship W1968782753A5006719547 @default.
• W1968782753 hasAuthorship W1968782753A5011835067 @default.
• W1968782753 hasAuthorship W1968782753A5018459204 @default.
• W1968782753 hasAuthorship W1968782753A5029634246 @default.
• W1968782753 hasAuthorship W1968782753A5036159697 @default.
• W1968782753 hasAuthorship W1968782753A5044742215 @default.
• W1968782753 hasAuthorship W1968782753A5049840120 @default.
• W1968782753 hasAuthorship W1968782753A5054508795 @default.
• W1968782753 hasAuthorship W1968782753A5066029512 @default.
• W1968782753 hasAuthorship W1968782753A5088539918 @default.
• W1968782753 hasConcept C114684123 @default.
• W1968782753 hasConcept C125473707 @default.
• W1968782753 hasConcept C126322002 @default.
• W1968782753 hasConcept C142724271 @default.
• W1968782753 hasConcept C167672396 @default.
• W1968782753 hasConcept C203014093 @default.
• W1968782753 hasConcept C204232928 @default.
• W1968782753 hasConcept C2776090121 @default.
• W1968782753 hasConcept C2779609443 @default.
• W1968782753 hasConcept C2779727006 @default.
• W1968782753 hasConcept C2780931953 @default.
• W1968782753 hasConcept C2911091166 @default.
• W1968782753 hasConcept C71924100 @default.
• W1968782753 hasConcept C74864618 @default.

• next