Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968784019> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1968784019 endingPage "452" @default.
- W1968784019 startingPage "439" @default.
- W1968784019 abstract "Abstract Neurturin (NTN) can improve the function and delay the rate of degeneration of dopaminergic neurons in Parkinson's disease (PD). However, its method of delivery to the central nervous system has not been established. Adenoviral vectors have been widely applied in gene therapy because of their high-efficiency gene transfer, easy manipulation, and safety. We used replication-defective adenovirus type 5 (Ad5) to construct a recombinant viral vector encoding full-length human NTN (Ad-NTN) and amplified Ad-NTN and the control (Ad-lacZ) in HEK 293 cells. NTN-specific expression in the Ad-NTN-infected HEK 293 cells was detected by RT-PCR and the immunofluorescent assay. However, no NTN expression was detected in the Ad-lacZ-infected HEK 293 cells. After incubation with the Ad-NTN-infected conditioned medium (CM), the dorsal root ganglia of chicken embryos examined in vitro exhibited radial neurite outgrowth around the ganglia. However, incubation with the Ad-lacZ-infected or blank CM resulted in a short or absent nerve process and the growth of only a few fibroblasts. Our findings indicated that recombinant Ad-NTN was specifically expressed in the host cells, and the expressed NTN possessed biological activity." @default.
- W1968784019 created "2016-06-24" @default.
- W1968784019 creator A5005071507 @default.
- W1968784019 creator A5014747513 @default.
- W1968784019 creator A5017975397 @default.
- W1968784019 creator A5028013653 @default.
- W1968784019 creator A5062482922 @default.
- W1968784019 creator A5070106136 @default.
- W1968784019 creator A5079520012 @default.
- W1968784019 creator A5087780600 @default.
- W1968784019 date "2009-09-09" @default.
- W1968784019 modified "2023-10-18" @default.
- W1968784019 title "Study on Construction, Expression, and Biological Activity of Recombinant Adenovirus of Neurturin" @default.
- W1968784019 cites W1554148270 @default.
- W1968784019 cites W1969800514 @default.
- W1968784019 cites W1985886057 @default.
- W1968784019 cites W1990735479 @default.
- W1968784019 cites W2007676211 @default.
- W1968784019 cites W2053124094 @default.
- W1968784019 cites W2063893203 @default.
- W1968784019 cites W2067283863 @default.
- W1968784019 cites W2087262420 @default.
- W1968784019 cites W2153406820 @default.
- W1968784019 doi "https://doi.org/10.1080/10826060903210107" @default.
- W1968784019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19739030" @default.
- W1968784019 hasPublicationYear "2009" @default.
- W1968784019 type Work @default.
- W1968784019 sameAs 1968784019 @default.
- W1968784019 citedByCount "0" @default.
- W1968784019 crossrefType "journal-article" @default.
- W1968784019 hasAuthorship W1968784019A5005071507 @default.
- W1968784019 hasAuthorship W1968784019A5014747513 @default.
- W1968784019 hasAuthorship W1968784019A5017975397 @default.
- W1968784019 hasAuthorship W1968784019A5028013653 @default.
- W1968784019 hasAuthorship W1968784019A5062482922 @default.
- W1968784019 hasAuthorship W1968784019A5070106136 @default.
- W1968784019 hasAuthorship W1968784019A5079520012 @default.
- W1968784019 hasAuthorship W1968784019A5087780600 @default.
- W1968784019 hasConcept C104317684 @default.
- W1968784019 hasConcept C111599444 @default.
- W1968784019 hasConcept C113246987 @default.
- W1968784019 hasConcept C153911025 @default.
- W1968784019 hasConcept C159047783 @default.
- W1968784019 hasConcept C160539049 @default.
- W1968784019 hasConcept C170493617 @default.
- W1968784019 hasConcept C174510640 @default.
- W1968784019 hasConcept C185856081 @default.
- W1968784019 hasConcept C202751555 @default.
- W1968784019 hasConcept C2776954459 @default.
- W1968784019 hasConcept C2777603835 @default.
- W1968784019 hasConcept C32470452 @default.
- W1968784019 hasConcept C40767141 @default.
- W1968784019 hasConcept C54009773 @default.
- W1968784019 hasConcept C54355233 @default.
- W1968784019 hasConcept C81885089 @default.
- W1968784019 hasConcept C86803240 @default.
- W1968784019 hasConcept C95444343 @default.
- W1968784019 hasConceptScore W1968784019C104317684 @default.
- W1968784019 hasConceptScore W1968784019C111599444 @default.
- W1968784019 hasConceptScore W1968784019C113246987 @default.
- W1968784019 hasConceptScore W1968784019C153911025 @default.
- W1968784019 hasConceptScore W1968784019C159047783 @default.
- W1968784019 hasConceptScore W1968784019C160539049 @default.
- W1968784019 hasConceptScore W1968784019C170493617 @default.
- W1968784019 hasConceptScore W1968784019C174510640 @default.
- W1968784019 hasConceptScore W1968784019C185856081 @default.
- W1968784019 hasConceptScore W1968784019C202751555 @default.
- W1968784019 hasConceptScore W1968784019C2776954459 @default.
- W1968784019 hasConceptScore W1968784019C2777603835 @default.
- W1968784019 hasConceptScore W1968784019C32470452 @default.
- W1968784019 hasConceptScore W1968784019C40767141 @default.
- W1968784019 hasConceptScore W1968784019C54009773 @default.
- W1968784019 hasConceptScore W1968784019C54355233 @default.
- W1968784019 hasConceptScore W1968784019C81885089 @default.
- W1968784019 hasConceptScore W1968784019C86803240 @default.
- W1968784019 hasConceptScore W1968784019C95444343 @default.
- W1968784019 hasIssue "4" @default.
- W1968784019 hasLocation W19687840191 @default.
- W1968784019 hasLocation W19687840192 @default.
- W1968784019 hasOpenAccess W1968784019 @default.
- W1968784019 hasPrimaryLocation W19687840191 @default.
- W1968784019 hasRelatedWork W1968784019 @default.
- W1968784019 hasRelatedWork W2358577340 @default.
- W1968784019 hasRelatedWork W2361821711 @default.
- W1968784019 hasRelatedWork W2384905744 @default.
- W1968784019 hasRelatedWork W2384972147 @default.
- W1968784019 hasRelatedWork W2385139158 @default.
- W1968784019 hasRelatedWork W2387969570 @default.
- W1968784019 hasRelatedWork W2388703198 @default.
- W1968784019 hasRelatedWork W2470353781 @default.
- W1968784019 hasRelatedWork W3032359831 @default.
- W1968784019 hasVolume "39" @default.
- W1968784019 isParatext "false" @default.
- W1968784019 isRetracted "false" @default.
- W1968784019 magId "1968784019" @default.
- W1968784019 workType "article" @default.