FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968785242> ?p ?o ?g. }

• W1968785242 endingPage "40" @default.
• W1968785242 startingPage "32" @default.
• W1968785242 abstract "Abstract We used oligonucleotide microarrays to investigate gene expression changes associated with multi‐step human papillomavirus type 16 (HPV16)‐mediated carcinogenesis in vitro . Gene expression profiles in 4 early passage HPV16‐immortalized human keratinocyte (HKc) lines derived from different donors were compared with their corresponding 4 late‐passage, differentiation‐resistant cell lines, and to 4 pools of normal HKc, each composed of 3 individual HKc strains, on Agilent 22 k human oligonucleotide microarrays. The resulting data were analyzed using a modified T‐test coded in R to obtain lists of differentially expressed genes. Gene expression changes identified in this model system were then compared with gene expression changes described in published studies of cervical intraepithelial neoplasia (CIN) and cervical cancer. Common genes in these lists were further studied by cluster analysis. Genes whose expression changed in the same direction as in CIN or cervical cancer (concordant) at late stages of HPV16‐mediated transformation in vitro formed one major cluster, while those that changed in the opposite direction (discordant) formed a second major cluster. Further annotation found that many discordant expression changes involved gene products with an extracellular localization. Two novel genes were selected for further study: overexpression of SIX1 and GDF15, observed during in vitro progression in our model system, was confirmed in tissue arrays of cervical cancer. These microarray‐based studies show that our in vitro model system reflects many cellular and molecular alterations characteristic of cervical cancer, and identified SIX1 and GDF15 as 2 novel potential biomarkers of cervical cancer progression. © 2008 Wiley‐Liss, Inc." @default.
• W1968785242 created "2016-06-24" @default.
• W1968785242 creator A5011222156 @default.
• W1968785242 creator A5012535442 @default.
• W1968785242 creator A5043848314 @default.
• W1968785242 creator A5057161976 @default.
• W1968785242 creator A5062495013 @default.
• W1968785242 creator A5065231902 @default.
• W1968785242 date "2008-04-24" @default.
• W1968785242 modified "2023-10-18" @default.
• W1968785242 title "Gene expression changes during HPV-mediated carcinogenesis: A comparison between an<i>in vitro</i>cell model and cervical cancer" @default.
• W1968785242 cites W1585578035 @default.
• W1968785242 cites W1798802566 @default.
• W1968785242 cites W1858263251 @default.
• W1968785242 cites W1983287748 @default.
• W1968785242 cites W1998637943 @default.
• W1968785242 cites W2009278796 @default.
• W1968785242 cites W2015021750 @default.
• W1968785242 cites W2016592525 @default.
• W1968785242 cites W2018733832 @default.
• W1968785242 cites W2022969051 @default.
• W1968785242 cites W2023615913 @default.
• W1968785242 cites W2030234603 @default.
• W1968785242 cites W2036087634 @default.
• W1968785242 cites W2038181603 @default.
• W1968785242 cites W2038500217 @default.
• W1968785242 cites W2043224583 @default.
• W1968785242 cites W2053238499 @default.
• W1968785242 cites W2053840275 @default.
• W1968785242 cites W2059718077 @default.
• W1968785242 cites W2059907870 @default.
• W1968785242 cites W2060786724 @default.
• W1968785242 cites W2061932727 @default.
• W1968785242 cites W2062694029 @default.
• W1968785242 cites W2063173033 @default.
• W1968785242 cites W2064030514 @default.
• W1968785242 cites W2065395166 @default.
• W1968785242 cites W2076875145 @default.
• W1968785242 cites W2087684630 @default.
• W1968785242 cites W2088056659 @default.
• W1968785242 cites W2100668965 @default.
• W1968785242 cites W2103324057 @default.
• W1968785242 cites W2108244474 @default.
• W1968785242 cites W2130701570 @default.
• W1968785242 cites W2132368439 @default.
• W1968785242 cites W2134053713 @default.
• W1968785242 cites W2143079531 @default.
• W1968785242 cites W2147246240 @default.
• W1968785242 cites W2151441644 @default.
• W1968785242 cites W2154251974 @default.
• W1968785242 cites W2155470210 @default.
• W1968785242 cites W2155612034 @default.
• W1968785242 cites W2157838504 @default.
• W1968785242 cites W2162148849 @default.
• W1968785242 cites W2170640097 @default.
• W1968785242 cites W2170785298 @default.
• W1968785242 cites W4253517795 @default.
• W1968785242 cites W4376522311 @default.
• W1968785242 cites W83439197 @default.
• W1968785242 doi "https://doi.org/10.1002/ijc.23463" @default.
• W1968785242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2872618" @default.
• W1968785242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18398830" @default.
• W1968785242 hasPublicationYear "2008" @default.
• W1968785242 type Work @default.
• W1968785242 sameAs 1968785242 @default.
• W1968785242 citedByCount "73" @default.
• W1968785242 countsByYear W19687852422012 @default.
• W1968785242 countsByYear W19687852422013 @default.
• W1968785242 countsByYear W19687852422014 @default.
• W1968785242 countsByYear W19687852422015 @default.
• W1968785242 countsByYear W19687852422016 @default.
• W1968785242 countsByYear W19687852422017 @default.
• W1968785242 countsByYear W19687852422018 @default.
• W1968785242 countsByYear W19687852422019 @default.
• W1968785242 countsByYear W19687852422020 @default.
• W1968785242 countsByYear W19687852422021 @default.
• W1968785242 countsByYear W19687852422023 @default.
• W1968785242 crossrefType "journal-article" @default.
• W1968785242 hasAuthorship W1968785242A5011222156 @default.
• W1968785242 hasAuthorship W1968785242A5012535442 @default.
• W1968785242 hasAuthorship W1968785242A5043848314 @default.
• W1968785242 hasAuthorship W1968785242A5057161976 @default.
• W1968785242 hasAuthorship W1968785242A5062495013 @default.
• W1968785242 hasAuthorship W1968785242A5065231902 @default.
• W1968785242 hasBestOaLocation W19687852421 @default.
• W1968785242 hasConcept C104317684 @default.
• W1968785242 hasConcept C121608353 @default.
• W1968785242 hasConcept C150194340 @default.
• W1968785242 hasConcept C153911025 @default.
• W1968785242 hasConcept C186836561 @default.
• W1968785242 hasConcept C2777343196 @default.
• W1968785242 hasConcept C2778220009 @default.
• W1968785242 hasConcept C502942594 @default.
• W1968785242 hasConcept C54355233 @default.
• W1968785242 hasConcept C555283112 @default.
• W1968785242 hasConcept C8415881 @default.
• W1968785242 hasConcept C86803240 @default.
• W1968785242 hasConcept C95371953 @default.

• next