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• W1968792207 startingPage "258" @default.
• W1968792207 abstract "Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) can protect some kinds of lymphocytes from apoptotic cell death. In contrast, the present study showed that the expression of LMP1 induced high susceptibility to tumor necrosis factor alpha (TNFalpha)-induced apoptosis in intestine 407 epithelial cells, without affecting expression of TNF receptors I and II. LMP1-deletion mutants lacking either C-terminal activation region (CTAR)-1 or CTAR-2 had ability to enhance TNFalpha-induced apoptosis, whereas the deletion of both activation regions completely abolished the induction of high susceptibility to TNFalpha. Phosphorylation of the NFkB-inhibitory molecule IkB-alpha, another biological activity of TNFalpha, was not enhanced by LMP1-expression. LMP1 upregulated antiapoptotic gene A20 expression, suggesting that A20 can not block TNFalpha-induced apoptosis in this cell system. Apoptosis triggered by TNFalpha in LMP1-expressing intestine 407 cells was blocked by inhibitors of caspases-8 and -3. It is therefore concluded that in intestine 407 epithelial cells, LMP1 enhances primarily signal cascade responsible for TNFalpha-induced apoptosis, which occurs at a level upstream of acting site of caspases-8 and -3 and that CTAR-1 and CTAR-2 are involved in enhancement of TNFalpha-induced apoptosis." @default.
• W1968792207 created "2016-06-24" @default.
• W1968792207 creator A5053280611 @default.
• W1968792207 date "2000-05-01" @default.
• W1968792207 modified "2023-10-18" @default.
• W1968792207 title "The Epstein–Barr Virus Latent Membrane Protein 1 (LMP1) Enhances TNF Alpha-Induced Apoptosis of Intestine 407 Epithelial Cells: The Role of LMP1 C-Terminal Activation Regions 1 and 2" @default.
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• W1968792207 doi "https://doi.org/10.1006/viro.2000.0296" @default.
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