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• W1968804551 abstract "Malignant melanoma represents one of the most aggressive malignancies but outcome is highly variable with early tumor lesions having an excellent prognosis following resection. We review here the data on identification of genes involved in the progression of melanoma as a result of expression array studies, genomic profiling, and genetic models. We focus on the role of tumor suppressors involved in cell cycle function, DNA repair, and genome maintenance. Highlighted are the roles of loss of p16 in promoting neoplasia in cooperation with deregulated MAPK signaling, and the role of loss of the RASSF1A protein in promoting chromosomal instability. The interactions between point mutation in growth signaling molecules and epigenetic changes in genes involved in DNA repair and cell division are discussed." @default.
• W1968804551 created "2016-06-24" @default.
• W1968804551 creator A5006937666 @default.
• W1968804551 creator A5035537034 @default.
• W1968804551 date "2009-06-01" @default.
• W1968804551 modified "2023-10-14" @default.
• W1968804551 title "Molecular Markers of Tumor Progression in Melanoma" @default.
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• W1968804551 doi "https://doi.org/10.2174/138920209788488526" @default.
• W1968804551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2709934" @default.
• W1968804551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19949544" @default.
• W1968804551 hasPublicationYear "2009" @default.
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