Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968805176> ?p ?o ?g. }
- W1968805176 endingPage "406" @default.
- W1968805176 startingPage "397" @default.
- W1968805176 abstract "Abstract In vitro studies have clearly shown that signaling/guidance proteins can diffuse to their targets. However, it is unclear whether they can travel by diffusion in vivo , or if they are distributed in the tissue by an active mechanism. Retinoschisin, a signaling molecule related to neuropilins, is synthesized and secreted by photoreceptor cells in the outer retina; then it interacts with inner retinal cells contributing to synaptic organization and optic nerve fiber integrity. We developed an assay to examine how retinoschisin, which is secreted a distance away, reaches its inner retinal targets. We found that retinoschisin is preferentially taken up and carried into the inner retina from the retinal outer border (the photoreceptor side) by Müller cells (the main glial cells of the vertebrate retina). This transcytosis is disrupted by DL ‐α‐aminoadipic acid, a Müller cell/glia‐specific toxin. Our results suggest that glial uptake/transcytosis can provide an effective and precise alternative for distributing signaling molecules in the nervous system. © 2004 Wiley‐Liss, Inc." @default.
- W1968805176 created "2016-06-24" @default.
- W1968805176 creator A5002098574 @default.
- W1968805176 creator A5005767794 @default.
- W1968805176 date "2004-11-10" @default.
- W1968805176 modified "2023-10-13" @default.
- W1968805176 title "Glial transcytosis of a photoreceptor-secreted signaling protein, retinoschisin" @default.
- W1968805176 cites W1512026426 @default.
- W1968805176 cites W1527835237 @default.
- W1968805176 cites W1967349182 @default.
- W1968805176 cites W1974019768 @default.
- W1968805176 cites W1976032516 @default.
- W1968805176 cites W1982933013 @default.
- W1968805176 cites W1983681542 @default.
- W1968805176 cites W1983926856 @default.
- W1968805176 cites W1989323173 @default.
- W1968805176 cites W1994898970 @default.
- W1968805176 cites W1996386536 @default.
- W1968805176 cites W2018581402 @default.
- W1968805176 cites W2021267530 @default.
- W1968805176 cites W2021782623 @default.
- W1968805176 cites W2030723260 @default.
- W1968805176 cites W2033712349 @default.
- W1968805176 cites W2034842977 @default.
- W1968805176 cites W2038937988 @default.
- W1968805176 cites W2042273549 @default.
- W1968805176 cites W2048208037 @default.
- W1968805176 cites W2053246781 @default.
- W1968805176 cites W2061226862 @default.
- W1968805176 cites W2063537428 @default.
- W1968805176 cites W2080270797 @default.
- W1968805176 cites W2082600620 @default.
- W1968805176 cites W2085545818 @default.
- W1968805176 cites W2124248841 @default.
- W1968805176 cites W2130486373 @default.
- W1968805176 cites W2139850065 @default.
- W1968805176 cites W2143349983 @default.
- W1968805176 cites W2144797754 @default.
- W1968805176 cites W2150231680 @default.
- W1968805176 cites W2153379835 @default.
- W1968805176 doi "https://doi.org/10.1002/glia.20131" @default.
- W1968805176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15538749" @default.
- W1968805176 hasPublicationYear "2004" @default.
- W1968805176 type Work @default.
- W1968805176 sameAs 1968805176 @default.
- W1968805176 citedByCount "25" @default.
- W1968805176 countsByYear W19688051762014 @default.
- W1968805176 countsByYear W19688051762015 @default.
- W1968805176 countsByYear W19688051762017 @default.
- W1968805176 countsByYear W19688051762018 @default.
- W1968805176 countsByYear W19688051762022 @default.
- W1968805176 crossrefType "journal-article" @default.
- W1968805176 hasAuthorship W1968805176A5002098574 @default.
- W1968805176 hasAuthorship W1968805176A5005767794 @default.
- W1968805176 hasConcept C1491633281 @default.
- W1968805176 hasConcept C150555746 @default.
- W1968805176 hasConcept C169760540 @default.
- W1968805176 hasConcept C185350488 @default.
- W1968805176 hasConcept C201750760 @default.
- W1968805176 hasConcept C2777093970 @default.
- W1968805176 hasConcept C2777102633 @default.
- W1968805176 hasConcept C2780827179 @default.
- W1968805176 hasConcept C28005876 @default.
- W1968805176 hasConcept C28328180 @default.
- W1968805176 hasConcept C55493867 @default.
- W1968805176 hasConcept C62478195 @default.
- W1968805176 hasConcept C86803240 @default.
- W1968805176 hasConcept C95444343 @default.
- W1968805176 hasConceptScore W1968805176C1491633281 @default.
- W1968805176 hasConceptScore W1968805176C150555746 @default.
- W1968805176 hasConceptScore W1968805176C169760540 @default.
- W1968805176 hasConceptScore W1968805176C185350488 @default.
- W1968805176 hasConceptScore W1968805176C201750760 @default.
- W1968805176 hasConceptScore W1968805176C2777093970 @default.
- W1968805176 hasConceptScore W1968805176C2777102633 @default.
- W1968805176 hasConceptScore W1968805176C2780827179 @default.
- W1968805176 hasConceptScore W1968805176C28005876 @default.
- W1968805176 hasConceptScore W1968805176C28328180 @default.
- W1968805176 hasConceptScore W1968805176C55493867 @default.
- W1968805176 hasConceptScore W1968805176C62478195 @default.
- W1968805176 hasConceptScore W1968805176C86803240 @default.
- W1968805176 hasConceptScore W1968805176C95444343 @default.
- W1968805176 hasIssue "3" @default.
- W1968805176 hasLocation W19688051761 @default.
- W1968805176 hasLocation W19688051762 @default.
- W1968805176 hasOpenAccess W1968805176 @default.
- W1968805176 hasPrimaryLocation W19688051761 @default.
- W1968805176 hasRelatedWork W1220992234 @default.
- W1968805176 hasRelatedWork W1977334515 @default.
- W1968805176 hasRelatedWork W2013808784 @default.
- W1968805176 hasRelatedWork W2037746501 @default.
- W1968805176 hasRelatedWork W2055699142 @default.
- W1968805176 hasRelatedWork W2093210804 @default.
- W1968805176 hasRelatedWork W2119498694 @default.
- W1968805176 hasRelatedWork W2411060299 @default.
- W1968805176 hasRelatedWork W2889478730 @default.
- W1968805176 hasRelatedWork W2996463122 @default.
- W1968805176 hasVolume "49" @default.