Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968810311> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1968810311 endingPage "59" @default.
- W1968810311 startingPage "51" @default.
- W1968810311 abstract "The selectivity of hepatitis C virus (HCV) non-structural protein 3 (NS3) protease inhibitors was determined by evaluating their inhibitory effect on other serine proteases (human leukocyte elastase (HLE), porcine pancreatic elastase (PPE), bovine pancreatic chymotrypsin (BPC)) and a cysteine protease (cathepsin B). For these peptide inhibitors, the P1-side chain and the C-terminal group were the major determinants of selectivity. Inhibitors with electrophilic C-terminal residues were generally non-selective while compounds with non-electrophilic C-terminal residues were more selective. Furthermore, compounds with P1 aminobutyric acid residues were non-selective, while 1-aminocyclopropane-1-carboxylic acid (ACPC) and norvaline-based inhibitors were generally selective. The most potent and selective inhibitors of NS3 protease tested contained a non-electrophilic phenyl acyl sulfonamide C-terminal residue. HLE was most likely to be inhibited by the HCV protease inhibitors, in agreement with similar substrate specificities for these enzymes. The identified structure–activity relationships for selectivity are of significance for design of selective HCV NS3 protease inhibitors." @default.
- W1968810311 created "2016-06-24" @default.
- W1968810311 creator A5033285189 @default.
- W1968810311 creator A5037343733 @default.
- W1968810311 creator A5038720064 @default.
- W1968810311 creator A5051487905 @default.
- W1968810311 creator A5069775097 @default.
- W1968810311 creator A5070177216 @default.
- W1968810311 creator A5072741116 @default.
- W1968810311 date "2004-04-01" @default.
- W1968810311 modified "2023-10-09" @default.
- W1968810311 title "Structure–activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors" @default.
- W1968810311 cites W1979919755 @default.
- W1968810311 cites W2006309458 @default.
- W1968810311 cites W2017728873 @default.
- W1968810311 cites W2019967258 @default.
- W1968810311 cites W2040180046 @default.
- W1968810311 cites W2048466829 @default.
- W1968810311 cites W2056038184 @default.
- W1968810311 cites W2060444111 @default.
- W1968810311 cites W2063072523 @default.
- W1968810311 cites W2064230725 @default.
- W1968810311 cites W2065625486 @default.
- W1968810311 cites W2079722424 @default.
- W1968810311 cites W2081940358 @default.
- W1968810311 cites W2082774080 @default.
- W1968810311 cites W2099272027 @default.
- W1968810311 cites W2108093903 @default.
- W1968810311 cites W2124496560 @default.
- W1968810311 cites W2137177799 @default.
- W1968810311 cites W2139248396 @default.
- W1968810311 cites W2139624902 @default.
- W1968810311 cites W2142684817 @default.
- W1968810311 cites W2316906755 @default.
- W1968810311 cites W2953146212 @default.
- W1968810311 doi "https://doi.org/10.1016/j.bbagen.2004.02.008" @default.
- W1968810311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15056493" @default.
- W1968810311 hasPublicationYear "2004" @default.
- W1968810311 type Work @default.
- W1968810311 sameAs 1968810311 @default.
- W1968810311 citedByCount "19" @default.
- W1968810311 countsByYear W19688103112012 @default.
- W1968810311 countsByYear W19688103112018 @default.
- W1968810311 countsByYear W19688103112019 @default.
- W1968810311 countsByYear W19688103112020 @default.
- W1968810311 countsByYear W19688103112022 @default.
- W1968810311 crossrefType "journal-article" @default.
- W1968810311 hasAuthorship W1968810311A5033285189 @default.
- W1968810311 hasAuthorship W1968810311A5037343733 @default.
- W1968810311 hasAuthorship W1968810311A5038720064 @default.
- W1968810311 hasAuthorship W1968810311A5051487905 @default.
- W1968810311 hasAuthorship W1968810311A5069775097 @default.
- W1968810311 hasAuthorship W1968810311A5070177216 @default.
- W1968810311 hasAuthorship W1968810311A5072741116 @default.
- W1968810311 hasConcept C132379496 @default.
- W1968810311 hasConcept C181199279 @default.
- W1968810311 hasConcept C182220744 @default.
- W1968810311 hasConcept C185592680 @default.
- W1968810311 hasConcept C2776714187 @default.
- W1968810311 hasConcept C2777807008 @default.
- W1968810311 hasConcept C2778401398 @default.
- W1968810311 hasConcept C2780340462 @default.
- W1968810311 hasConcept C55493867 @default.
- W1968810311 hasConcept C71240020 @default.
- W1968810311 hasConceptScore W1968810311C132379496 @default.
- W1968810311 hasConceptScore W1968810311C181199279 @default.
- W1968810311 hasConceptScore W1968810311C182220744 @default.
- W1968810311 hasConceptScore W1968810311C185592680 @default.
- W1968810311 hasConceptScore W1968810311C2776714187 @default.
- W1968810311 hasConceptScore W1968810311C2777807008 @default.
- W1968810311 hasConceptScore W1968810311C2778401398 @default.
- W1968810311 hasConceptScore W1968810311C2780340462 @default.
- W1968810311 hasConceptScore W1968810311C55493867 @default.
- W1968810311 hasConceptScore W1968810311C71240020 @default.
- W1968810311 hasIssue "1" @default.
- W1968810311 hasLocation W19688103111 @default.
- W1968810311 hasLocation W19688103112 @default.
- W1968810311 hasOpenAccess W1968810311 @default.
- W1968810311 hasPrimaryLocation W19688103111 @default.
- W1968810311 hasRelatedWork W124183450 @default.
- W1968810311 hasRelatedWork W1596676072 @default.
- W1968810311 hasRelatedWork W2048277394 @default.
- W1968810311 hasRelatedWork W2068975409 @default.
- W1968810311 hasRelatedWork W2109018839 @default.
- W1968810311 hasRelatedWork W2153970031 @default.
- W1968810311 hasRelatedWork W2156654812 @default.
- W1968810311 hasRelatedWork W2182122486 @default.
- W1968810311 hasRelatedWork W3195890830 @default.
- W1968810311 hasRelatedWork W3207552102 @default.
- W1968810311 hasVolume "1672" @default.
- W1968810311 isParatext "false" @default.
- W1968810311 isRetracted "false" @default.
- W1968810311 magId "1968810311" @default.
- W1968810311 workType "article" @default.