FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968810589> ?p ?o ?g. }

• W1968810589 endingPage "1537" @default.
• W1968810589 startingPage "1531" @default.
• W1968810589 abstract "The S component (LukS-PV) is one of the two components of Panton-Valentine leukocidin (PVL), which is a pore-forming cytotoxin secreted by Staphylococcus aureus, with the ability to lyse leukocytes. In this study, LukS-PV had the ability to induce apoptosis in the human acute myeloid leukemia (AML) cell line THP-1. Therefore, we investigated the mechanisms of LukS-PV-induced apoptosis in THP-1 cells. THP-1 cells treated with LukS-PV, resulted in a significant inhibition of proliferation in a dose- and time-dependent manner, and induced G0/G1 arrest associated with an inhibition of cell cycle arrest regulatory protein (cyclin D1) in a dose- and time-dependent manner, as measured by flow cytometry (FCM). After 12h exposure to LukS-PV (1.00 μM), annexin V-EGFP/propidium iodide (PI) FCM revealed that 19.5±3.6% of THP-1 cells were apoptotic, and terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) staining also revealed THP-1 cells were apoptotic. Chip analysis of 84 apoptosis-related genes demonstrated that 9 genes were up-regulated at least 2-fold and that 5 genes were down-regulated at least 2-fold in the treatment group when compared with levels in the control group. Western blotting reveled that the expression of caspase-8 increased significantly (approximately 4-fold). The levels of caspase-9, -3 and Bax increased significantly, and levels of Bcl-2 decreased rapidly with LukS-PV treatment. These data suggest that LukS-PV acts as an anti-leukemia agent and activates AML cell apoptosis via the mitochondrial pathway. Therefore, LukS-PV may be a multi-targeting drug candidate for the prevention and therapy of AML." @default.
• W1968810589 created "2016-06-24" @default.
• W1968810589 creator A5003896541 @default.
• W1968810589 creator A5004032681 @default.
• W1968810589 creator A5017135571 @default.
• W1968810589 creator A5031054509 @default.
• W1968810589 creator A5031730140 @default.
• W1968810589 creator A5075952560 @default.
• W1968810589 date "2013-08-01" @default.
• W1968810589 modified "2023-10-01" @default.
• W1968810589 title "LukS-PV induces mitochondrial-mediated apoptosis and G0/G1 cell cycle arrest in human acute myeloid leukemia THP-1 cells" @default.
• W1968810589 cites W1598164462 @default.
• W1968810589 cites W1819236465 @default.
• W1968810589 cites W1963726513 @default.
• W1968810589 cites W1966176339 @default.
• W1968810589 cites W1968615630 @default.
• W1968810589 cites W1971042394 @default.
• W1968810589 cites W1973058952 @default.
• W1968810589 cites W1984547206 @default.
• W1968810589 cites W1988501212 @default.
• W1968810589 cites W1993728532 @default.
• W1968810589 cites W2002070061 @default.
• W1968810589 cites W2002218478 @default.
• W1968810589 cites W2006454384 @default.
• W1968810589 cites W2007077012 @default.
• W1968810589 cites W2020333601 @default.
• W1968810589 cites W2025128734 @default.
• W1968810589 cites W2048217985 @default.
• W1968810589 cites W2062892895 @default.
• W1968810589 cites W2063495408 @default.
• W1968810589 cites W2069691728 @default.
• W1968810589 cites W2073028327 @default.
• W1968810589 cites W2081035137 @default.
• W1968810589 cites W2084046310 @default.
• W1968810589 cites W2084602777 @default.
• W1968810589 cites W2086196271 @default.
• W1968810589 cites W2103783390 @default.
• W1968810589 cites W2107367266 @default.
• W1968810589 cites W2128549860 @default.
• W1968810589 cites W2132411546 @default.
• W1968810589 cites W2136269288 @default.
• W1968810589 cites W2138666908 @default.
• W1968810589 cites W2141998397 @default.
• W1968810589 cites W2153827649 @default.
• W1968810589 cites W2162517282 @default.
• W1968810589 cites W2171676482 @default.
• W1968810589 cites W4239718055 @default.
• W1968810589 doi "https://doi.org/10.1016/j.biocel.2013.05.011" @default.
• W1968810589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23702031" @default.
• W1968810589 hasPublicationYear "2013" @default.
• W1968810589 type Work @default.
• W1968810589 sameAs 1968810589 @default.
• W1968810589 citedByCount "19" @default.
• W1968810589 countsByYear W19688105892014 @default.
• W1968810589 countsByYear W19688105892015 @default.
• W1968810589 countsByYear W19688105892016 @default.
• W1968810589 countsByYear W19688105892017 @default.
• W1968810589 countsByYear W19688105892019 @default.
• W1968810589 countsByYear W19688105892020 @default.
• W1968810589 countsByYear W19688105892021 @default.
• W1968810589 countsByYear W19688105892022 @default.
• W1968810589 countsByYear W19688105892023 @default.
• W1968810589 crossrefType "journal-article" @default.
• W1968810589 hasAuthorship W1968810589A5003896541 @default.
• W1968810589 hasAuthorship W1968810589A5004032681 @default.
• W1968810589 hasAuthorship W1968810589A5017135571 @default.
• W1968810589 hasAuthorship W1968810589A5031054509 @default.
• W1968810589 hasAuthorship W1968810589A5031730140 @default.
• W1968810589 hasAuthorship W1968810589A5075952560 @default.
• W1968810589 hasConcept C153911025 @default.
• W1968810589 hasConcept C190283241 @default.
• W1968810589 hasConcept C196795494 @default.
• W1968810589 hasConcept C204258353 @default.
• W1968810589 hasConcept C2775934118 @default.
• W1968810589 hasConcept C2778729363 @default.
• W1968810589 hasConcept C29537977 @default.
• W1968810589 hasConcept C31573885 @default.
• W1968810589 hasConcept C502942594 @default.
• W1968810589 hasConcept C54355233 @default.
• W1968810589 hasConcept C553184892 @default.
• W1968810589 hasConcept C55493867 @default.
• W1968810589 hasConcept C81885089 @default.
• W1968810589 hasConcept C86803240 @default.
• W1968810589 hasConceptScore W1968810589C153911025 @default.
• W1968810589 hasConceptScore W1968810589C190283241 @default.
• W1968810589 hasConceptScore W1968810589C196795494 @default.
• W1968810589 hasConceptScore W1968810589C204258353 @default.
• W1968810589 hasConceptScore W1968810589C2775934118 @default.
• W1968810589 hasConceptScore W1968810589C2778729363 @default.
• W1968810589 hasConceptScore W1968810589C29537977 @default.
• W1968810589 hasConceptScore W1968810589C31573885 @default.
• W1968810589 hasConceptScore W1968810589C502942594 @default.
• W1968810589 hasConceptScore W1968810589C54355233 @default.
• W1968810589 hasConceptScore W1968810589C553184892 @default.
• W1968810589 hasConceptScore W1968810589C55493867 @default.
• W1968810589 hasConceptScore W1968810589C81885089 @default.
• W1968810589 hasConceptScore W1968810589C86803240 @default.
• W1968810589 hasFunder F4320334897 @default.

• next