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• W1968832219 abstract "Annals of the New York Academy of SciencesVolume 850, Issue 1 p. 386-390 Full Developmental Silencing of the Embryonic ζ-Globin Gene Reflects Instability of its mRNA J. ERIC RUSSELL, Corresponding Author J. ERIC RUSSELL Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Address for correspondence: J. Eric Russell, M.D., Abramson Research Building, Room 316F, Children's Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104. Tel: 215-590-3880; Fax: 215-590-4834; E-mail: [email protected]Search for more papers by this authorALICE E. LEE, ALICE E. LEE Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USASearch for more papers by this authorSTEPHEN A. LIEBHABER, STEPHEN A. LIEBHABER Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Department of Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USASearch for more papers by this author J. ERIC RUSSELL, Corresponding Author J. ERIC RUSSELL Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Address for correspondence: J. Eric Russell, M.D., Abramson Research Building, Room 316F, Children's Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104. Tel: 215-590-3880; Fax: 215-590-4834; E-mail: [email protected]Search for more papers by this authorALICE E. LEE, ALICE E. LEE Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USASearch for more papers by this authorSTEPHEN A. LIEBHABER, STEPHEN A. LIEBHABER Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Department of Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USASearch for more papers by this author First published: 07 February 2006 https://doi.org/10.1111/j.1749-6632.1998.tb10499.xRead the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Yagi, M. et al. 1996. Chromatin structure and developmental expression of the human α-globin cluster. Mol. Cell. Biol. 6: 1108–16. 2 Albitar, M. et al. 1989. Theta, zeta, and epsilon globin messenger RNAs are expressed in adults. Blood 74: 629–637. 3 Liebhaber, S. A. et al. 1996. Developmental silencing of the embryonic ζ-globin gene: concerted action of the promoter and the 3′ flanking region combined with stage-specific silencing of the transcribed segment. Mol. Cell. Biol. 16: 2637–2646. 4 Wang, X. et al. 1995. Detection and characterization of a 3′ untranslated region ribonucleoprotein complex associated with human α-globin mRNA stability. Mol. Cell. Biol. 15: 1769–1777. 5 Kiledjian, M. et al. 1995. Identification of two KH domain proteins in the α-globin mRNP stability complex. EMBO J. 14: 4357–4364. 6 Morales, J. et al. 1997. Destabilization of human α-globin mRNA by translation anti-termination is controlled during erythroid differentiation and paralleled by phased shortening of the poly(A) tail. J. Biol. Chem. 272: 6607–6613. 7 Russell, J. E. et al. 1998. Sequence divergence in the 3′ untranslated regions of human ζ- and α-globin mRNAs mediates a difference in their stabilities and contributes to efficient α-to-ζ gene developmental switching. Mol. Cell Biol. 18: 2173–2183. 8 Wisdom, R. et al. 1991 The protein coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors. Genes Develop. 5: 232–243. Volume850, Issue1COOLEY'S ANEMIA: SEVENTH SYMPOSIUMJune 1998Pages 386-390 ReferencesRelatedInformation" @default.
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• W1968832219 title "Full Developmental Silencing of the Embryonic zeta-Globin Gene Reflects Instability of its mRNA" @default.
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