FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968846839> ?p ?o ?g. }

• W1968846839 endingPage "1034" @default.
• W1968846839 startingPage "1028" @default.
• W1968846839 abstract "<h3>Objective</h3> Prenatal alcohol exposure results in fetal death and neurobehavioral complications including learning impairment. Previously synthetic peptides derived from activity-dependent neurotrophic factor have been shown to prevent aspects of alcohol-induced damage in pregnancy. The objective of this work was to evaluate whether activity-dependent neurotrophic factor-12 could prevent alcohol-induced damage in a model of fetal alcohol syndrome. <h3>Study design</h3> Using a well-characterized model, C57Bl6/J mice on gestational day 8 were treated with placebo, alcohol (30% volume/volume alcohol 0.03 mL/kg), alcohol plus activity-dependent neurotrophic factor-12 30 minutes prior to alcohol, or activity-dependent neurotrophic factor-12 alone. Fetal death was assessed on gestational day 18 (25 litters were evaluated: alcohol, n=5; placebo, n=9; alcohol plus activity-dependent neurotrophic factor-12, n=11). Neonatal behavior tests were performed on postnatal days 1 through 21 with the offspring of 12 dams (alcohol, n=16; placebo, n=46; alcohol plus activity-dependent neurotrophic factor-12, n=23; and activity-dependent neurotrophic factor-12, n=35). Adult males were tested in the Morris water maze for learning assessment and with the hole punch activity test for exploratory activity. Statistical analysis included Kruskal-Wallis and analysis of variance. <h3>Results</h3> Fetal death was greater in alcohol (67% ± 13%) vs placebo (8.4% ± 3%, <i>P</i><.001). Pretreatment with activity-dependent neurotrophic factor-12 prevented the alcohol-induced fetal death (2.2% ± 8.1%) with levels similar to control (<i>P</i>=.12). Alcohol exposure caused a delay in achieving developmental milestones, with alcohol achieving milestones later than all other groups (all <i>P</i><.001). Pretreatment with activity-dependent neurotrophic factor-12 prevented the alcohol-induced milestone delays. In the Morris water maze, the placebo learned, decreasing their latency to find the hidden platform over 70% (<i>P</i><.01). Alcohol plus activity-dependent neurotrophic factor-12 also significantly learned, with a learning curve not different from placebo (all <i>P</i>>.5) and significantly better than alcohol on days 4, 6, and 7 (all <i>P</i><.05). Alcohol exposure resulted in significantly less time in hole punch activity (<i>P</i><.02) than control. Activity-dependent neurotrophic factor-12 pretreatment prevented the alcohol-induced decline, with levels the same as control (<i>P</i>=.1). <h3>Conclusion</h3> The novel peptide activity-dependent neurotrophic factor-12 prevents alcohol-induced fetal death and developmental and learning abnormalities in a model of fetal alcohol syndrome. This demonstrates that a single treatment with a peptide is efficacious and may be of value in the prevention of alcohol-induced damage." @default.
• W1968846839 created "2016-06-24" @default.
• W1968846839 creator A5001087659 @default.
• W1968846839 creator A5007592559 @default.
• W1968846839 creator A5007676851 @default.
• W1968846839 creator A5015262039 @default.
• W1968846839 creator A5051405380 @default.
• W1968846839 creator A5086959789 @default.
• W1968846839 creator A5089392066 @default.
• W1968846839 date "2005-09-01" @default.
• W1968846839 modified "2023-09-27" @default.
• W1968846839 title "Prevention of alcohol-induced developmental delays and learning abnormalities in a model of fetal alcohol syndrome" @default.
• W1968846839 cites W1971125122 @default.
• W1968846839 cites W1977156046 @default.
• W1968846839 cites W2003266651 @default.
• W1968846839 cites W2014761527 @default.
• W1968846839 cites W2017169966 @default.
• W1968846839 cites W2036382924 @default.
• W1968846839 cites W2053261189 @default.
• W1968846839 cites W2055479267 @default.
• W1968846839 cites W2162665706 @default.
• W1968846839 cites W4240977611 @default.
• W1968846839 doi "https://doi.org/10.1016/j.ajog.2005.05.052" @default.
• W1968846839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16157106" @default.
• W1968846839 hasPublicationYear "2005" @default.
• W1968846839 type Work @default.
• W1968846839 sameAs 1968846839 @default.
• W1968846839 citedByCount "36" @default.
• W1968846839 countsByYear W19688468392012 @default.
• W1968846839 countsByYear W19688468392014 @default.
• W1968846839 countsByYear W19688468392015 @default.
• W1968846839 countsByYear W19688468392016 @default.
• W1968846839 countsByYear W19688468392017 @default.
• W1968846839 countsByYear W19688468392018 @default.
• W1968846839 countsByYear W19688468392020 @default.
• W1968846839 countsByYear W19688468392022 @default.
• W1968846839 countsByYear W19688468392023 @default.
• W1968846839 crossrefType "journal-article" @default.
• W1968846839 hasAuthorship W1968846839A5001087659 @default.
• W1968846839 hasAuthorship W1968846839A5007592559 @default.
• W1968846839 hasAuthorship W1968846839A5007676851 @default.
• W1968846839 hasAuthorship W1968846839A5015262039 @default.
• W1968846839 hasAuthorship W1968846839A5051405380 @default.
• W1968846839 hasAuthorship W1968846839A5086959789 @default.
• W1968846839 hasAuthorship W1968846839A5089392066 @default.
• W1968846839 hasConcept C126322002 @default.
• W1968846839 hasConcept C134018914 @default.
• W1968846839 hasConcept C142724271 @default.
• W1968846839 hasConcept C160539049 @default.
• W1968846839 hasConcept C170493617 @default.
• W1968846839 hasConcept C204787440 @default.
• W1968846839 hasConcept C27081682 @default.
• W1968846839 hasConcept C2777601104 @default.
• W1968846839 hasConcept C2778790584 @default.
• W1968846839 hasConcept C2779234561 @default.
• W1968846839 hasConcept C2781066024 @default.
• W1968846839 hasConcept C46973012 @default.
• W1968846839 hasConcept C54355233 @default.
• W1968846839 hasConcept C55493867 @default.
• W1968846839 hasConcept C71924100 @default.
• W1968846839 hasConcept C86803240 @default.
• W1968846839 hasConceptScore W1968846839C126322002 @default.
• W1968846839 hasConceptScore W1968846839C134018914 @default.
• W1968846839 hasConceptScore W1968846839C142724271 @default.
• W1968846839 hasConceptScore W1968846839C160539049 @default.
• W1968846839 hasConceptScore W1968846839C170493617 @default.
• W1968846839 hasConceptScore W1968846839C204787440 @default.
• W1968846839 hasConceptScore W1968846839C27081682 @default.
• W1968846839 hasConceptScore W1968846839C2777601104 @default.
• W1968846839 hasConceptScore W1968846839C2778790584 @default.
• W1968846839 hasConceptScore W1968846839C2779234561 @default.
• W1968846839 hasConceptScore W1968846839C2781066024 @default.
• W1968846839 hasConceptScore W1968846839C46973012 @default.
• W1968846839 hasConceptScore W1968846839C54355233 @default.
• W1968846839 hasConceptScore W1968846839C55493867 @default.
• W1968846839 hasConceptScore W1968846839C71924100 @default.
• W1968846839 hasConceptScore W1968846839C86803240 @default.
• W1968846839 hasIssue "3" @default.
• W1968846839 hasLocation W19688468391 @default.
• W1968846839 hasLocation W19688468392 @default.
• W1968846839 hasOpenAccess W1968846839 @default.
• W1968846839 hasPrimaryLocation W19688468391 @default.
• W1968846839 hasRelatedWork W1573791126 @default.
• W1968846839 hasRelatedWork W1811706535 @default.
• W1968846839 hasRelatedWork W1972449685 @default.
• W1968846839 hasRelatedWork W2012996849 @default.
• W1968846839 hasRelatedWork W2028713882 @default.
• W1968846839 hasRelatedWork W2086317124 @default.
• W1968846839 hasRelatedWork W2104295145 @default.
• W1968846839 hasRelatedWork W2137198580 @default.
• W1968846839 hasRelatedWork W2160961970 @default.
• W1968846839 hasRelatedWork W2092333593 @default.
• W1968846839 hasVolume "193" @default.
• W1968846839 isParatext "false" @default.
• W1968846839 isRetracted "false" @default.
• W1968846839 magId "1968846839" @default.
• W1968846839 workType "article" @default.