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- W1968851685 abstract "The persistence of human immunodeficiency virus type 1 (HIV-1) in latent reservoirs is a major barrier to HIV cure. Reservoir establishment depends on low viral expression that may be related to provirus integration sites (IS). In vitro, in cell lines and primary T cells, latency is associated with specific IS through reduced viral expression mediated by transcriptional interference by host cellular promoters, reverse orientation, and the presence of specific epigenetic modifiers. In primary T cell models of latency, specific IS are associated with intracellular viral antigen expression that is not directly related to cell activation. In contrast, in patient CD4+ T cells, there is enrichment for IS in genes controlling cell cycle and survival and in some clonally expanded T cell subpopulations. Multiple insertion sites within some specific genes may suggest that integrated HIV can increase the host’s T cell survival." @default.
- W1968851685 created "2016-06-24" @default.
- W1968851685 creator A5046486071 @default.
- W1968851685 creator A5055398640 @default.
- W1968851685 date "2015-01-09" @default.
- W1968851685 modified "2023-10-16" @default.
- W1968851685 title "Human Immunodeficiency Virus (HIV)-1 Integration Sites in Viral Latency" @default.
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- W1968851685 doi "https://doi.org/10.1007/s11904-014-0241-9" @default.
- W1968851685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4369282" @default.
- W1968851685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25573791" @default.
- W1968851685 hasPublicationYear "2015" @default.
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