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- W1968854526 abstract "Endostatin, a 20-kDa proteolytic fragment of collagen XVIII, is a potent inhibitor of angiogenesis and tumor growth. The anti-angiogenic effects of endostatin include inhibition of endothelial cell migration and proliferation, and inhibition of the activity of MMP2. Structure-function analysis of endostatin that implies this contravention function buried in separate fragments of endostatin introduces new issues into the understanding of the structure-function relationship of endostatin. We developed and characterized a novel murine MAb, 4E7, to human endostatin, which antagonizes the function of endostatin. As we show here, MAb 4E7 blocks the anti-migration/adhesion effects of endostatin in vitro and the anti-angiogenesis effect of endostatin in vivo, but the inhibition effect of endostatin on endothelial cell proliferation is not affected by MAb4E7. These results suggest that the anti-migration and anti-proliferation functions of endostatin may have distinct structural foundations." @default.
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- W1968854526 date "2005-02-01" @default.
- W1968854526 modified "2023-10-17" @default.
- W1968854526 title "Characterization of a Monoclonal Antibody That Antagonizes the Function of Human Endostatin" @default.
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- W1968854526 doi "https://doi.org/10.1089/hyb.2005.24.42" @default.
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