Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968854876> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1968854876 endingPage "370" @default.
- W1968854876 startingPage "363" @default.
- W1968854876 abstract "We studied the antitumor effects of photodynamic therapy (PDT) with Zincphyrin, coproporphyrin III with zinc, derived from Streptomyces sp. AC8007, in vitro and in vivo. The photokilling effect of Zincphyrin in the presence of 0.78-100 microg/ml with visible light of 27.2 mW x min/cm2 for 10 min was lower than the hematoporphyrin (Hp) used as a control with L5178Y or sarcoma-180 cells. On the other hand, Zincphyrin apparently reduced tumor growth after intraperitoneal injection at doses of 12.5-50 mg/kg with light irradiation of 75.48 mW x min/cm2 for 10 min in sarcoma-180-bearing mice. Although no mice treated with Zincphyrin died, Hp did cause the death of mice. In B-16 melanoma-bearing mice, both Zincphyrin and Hp had a similar phototherapic effect. Further improvement of the phototherapic effect was observed with the continuous administration of Zincphyrin at 12.5 mg/kg per day for 3 days. The concentration of Zincphyrin in the serum reached a maximum level of 16 microg/ml within 20 min, and the concentration remained at 4.2 microg/ml at 1 hour after the onset of treatment, indicating its rapid action in the body. No animals died after the intraperitoneal administration of Zincphyrin at 100 mg/kg plus exposure to light of 10 mW x min/cm2 for 2 hours, and the body weight of the mice did not decrease. In contrast, all animals receiving 100 mg/kg of Hp under the same conditions died. These results indicate that Zincphyrin would be a useful photosensitizer with low phototoxicity." @default.
- W1968854876 created "2016-06-24" @default.
- W1968854876 creator A5014829273 @default.
- W1968854876 creator A5020314644 @default.
- W1968854876 creator A5023684419 @default.
- W1968854876 creator A5033764996 @default.
- W1968854876 creator A5053794348 @default.
- W1968854876 date "2001-01-01" @default.
- W1968854876 modified "2023-09-25" @default.
- W1968854876 title "Antitumor Effect of Photodynamic Therapy with Zincphyrin, Zinc-coproporphyrin III, in Mice" @default.
- W1968854876 cites W109544339 @default.
- W1968854876 cites W1944132896 @default.
- W1968854876 cites W1993567358 @default.
- W1968854876 cites W1998424046 @default.
- W1968854876 cites W2002219362 @default.
- W1968854876 cites W2008239318 @default.
- W1968854876 cites W2013121231 @default.
- W1968854876 cites W2027055150 @default.
- W1968854876 cites W2028224679 @default.
- W1968854876 cites W2040775167 @default.
- W1968854876 cites W2060790010 @default.
- W1968854876 cites W2100120674 @default.
- W1968854876 cites W2156975699 @default.
- W1968854876 cites W2325628170 @default.
- W1968854876 cites W2342031933 @default.
- W1968854876 cites W4211024586 @default.
- W1968854876 doi "https://doi.org/10.1271/bbb.65.363" @default.
- W1968854876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11302170" @default.
- W1968854876 hasPublicationYear "2001" @default.
- W1968854876 type Work @default.
- W1968854876 sameAs 1968854876 @default.
- W1968854876 citedByCount "5" @default.
- W1968854876 countsByYear W19688548762018 @default.
- W1968854876 countsByYear W19688548762019 @default.
- W1968854876 countsByYear W19688548762023 @default.
- W1968854876 crossrefType "journal-article" @default.
- W1968854876 hasAuthorship W1968854876A5014829273 @default.
- W1968854876 hasAuthorship W1968854876A5020314644 @default.
- W1968854876 hasAuthorship W1968854876A5023684419 @default.
- W1968854876 hasAuthorship W1968854876A5033764996 @default.
- W1968854876 hasAuthorship W1968854876A5053794348 @default.
- W1968854876 hasConcept C142724271 @default.
- W1968854876 hasConcept C150903083 @default.
- W1968854876 hasConcept C178790620 @default.
- W1968854876 hasConcept C185592680 @default.
- W1968854876 hasConcept C207001950 @default.
- W1968854876 hasConcept C2778256501 @default.
- W1968854876 hasConcept C2780159080 @default.
- W1968854876 hasConcept C2780699678 @default.
- W1968854876 hasConcept C2781323092 @default.
- W1968854876 hasConcept C71924100 @default.
- W1968854876 hasConcept C86803240 @default.
- W1968854876 hasConcept C98274493 @default.
- W1968854876 hasConceptScore W1968854876C142724271 @default.
- W1968854876 hasConceptScore W1968854876C150903083 @default.
- W1968854876 hasConceptScore W1968854876C178790620 @default.
- W1968854876 hasConceptScore W1968854876C185592680 @default.
- W1968854876 hasConceptScore W1968854876C207001950 @default.
- W1968854876 hasConceptScore W1968854876C2778256501 @default.
- W1968854876 hasConceptScore W1968854876C2780159080 @default.
- W1968854876 hasConceptScore W1968854876C2780699678 @default.
- W1968854876 hasConceptScore W1968854876C2781323092 @default.
- W1968854876 hasConceptScore W1968854876C71924100 @default.
- W1968854876 hasConceptScore W1968854876C86803240 @default.
- W1968854876 hasConceptScore W1968854876C98274493 @default.
- W1968854876 hasIssue "2" @default.
- W1968854876 hasLocation W19688548761 @default.
- W1968854876 hasLocation W19688548762 @default.
- W1968854876 hasOpenAccess W1968854876 @default.
- W1968854876 hasPrimaryLocation W19688548761 @default.
- W1968854876 hasRelatedWork W2049288673 @default.
- W1968854876 hasRelatedWork W2053488089 @default.
- W1968854876 hasRelatedWork W2061776930 @default.
- W1968854876 hasRelatedWork W2168902130 @default.
- W1968854876 hasRelatedWork W2279527986 @default.
- W1968854876 hasRelatedWork W2335264443 @default.
- W1968854876 hasRelatedWork W2351583258 @default.
- W1968854876 hasRelatedWork W2358821202 @default.
- W1968854876 hasRelatedWork W2375193779 @default.
- W1968854876 hasRelatedWork W1517655230 @default.
- W1968854876 hasVolume "65" @default.
- W1968854876 isParatext "false" @default.
- W1968854876 isRetracted "false" @default.
- W1968854876 magId "1968854876" @default.
- W1968854876 workType "article" @default.